tetano
Editor, Senior Moderator
Nat Immunol. 2013 Jan 13. doi: 10.1038/ni.2514. [Epub ahead of print]
IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8(+) T cell responses to influenza A virus.
Pang IK, Ichinohe T, Iwasaki A.
Source
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Abstract
Immune responses to vaccines require direct recognition of pathogen-associated molecular patterns (PAMPs) through pattern-recognition receptors (PRRs) on dendritic cells (DCs). Unlike vaccination, infection by a live pathogen often impairs DC function and inflicts additional damage on the host. Here we found that after infection with live influenza A virus, signaling through the interleukin 1 receptor (IL-1R) was required for productive priming of CD8(+) T cells, but signaling through the PRRs TLR7 and RIG-I was not. DCs activated by IL-1 in trans were both required and sufficient for the generation of virus-specific CD8(+) T cell immunity. Our data demonstrate a critical role for a bystander cytokine in the priming of CD8(+) T cells during infection with a live virus.
PMID:
23314004
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23314004
IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8(+) T cell responses to influenza A virus.
Pang IK, Ichinohe T, Iwasaki A.
Source
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Abstract
Immune responses to vaccines require direct recognition of pathogen-associated molecular patterns (PAMPs) through pattern-recognition receptors (PRRs) on dendritic cells (DCs). Unlike vaccination, infection by a live pathogen often impairs DC function and inflicts additional damage on the host. Here we found that after infection with live influenza A virus, signaling through the interleukin 1 receptor (IL-1R) was required for productive priming of CD8(+) T cells, but signaling through the PRRs TLR7 and RIG-I was not. DCs activated by IL-1 in trans were both required and sufficient for the generation of virus-specific CD8(+) T cell immunity. Our data demonstrate a critical role for a bystander cytokine in the priming of CD8(+) T cells during infection with a live virus.
PMID:
23314004
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23314004