tetano
Editor, Senior Moderator
IJID Reg
. 2022 Dec 15.
doi: 10.1016/j.ijregi.2022.12.003. Online ahead of print.
Characteristics and clinical outcomes of COVID-19 in children: A hospital-based surveillance study in Latin America's hardest-hit city
Daniel Jarovsky[SUP] 1 2 [/SUP], Giuliana de Freitas Fongaro[SUP] 1 [/SUP], Renata Mazzotti Zampol[SUP] 1 [/SUP], Thales Araújo de Oliveira[SUP] 1 [/SUP], Camila Giuliana Almeida Farias[SUP] 1 [/SUP], Daniella Gregória Bomfim Prado da Silva[SUP] 1 [/SUP], Denis Tadeu Gomes Cavalcante[SUP] 1 [/SUP], Sabrina Bortolin Nery[SUP] 1 [/SUP], José Cassio de Moraes[SUP] 2 [/SUP], Francisco Ivanildo de Oliveira Junior[SUP] 1 [/SUP], Flávia Jacqueline Almeida[SUP] 1 2 [/SUP], Marco Aurélio Palazzi Sáfadi[SUP] 1 2 [/SUP]
Affiliations
Abstract
Background: : In 2020, Brazil became the coronavirus disease (COVID-19) pandemic's epicenter in Latin America, resulting in an unparalleled health catastrophe. Nevertheless, comprehensive clinical reports in Brazilian children are unavailable.
Methods: : This retrospective, hospital-based, active-surveillance study was performed to identify pediatric patients with COVID-19 presenting at a private academic medical center in a large urban area between March 2020 and March 2021. Clinical and demographic information was analyzed among those requiring hospitalization, those with severe illness, and those with clinical syndromes.
Results 964 cases of symptomatic conditions were evaluated: : 17.7% required hospitalization, 27.5% of which were classified as severe/critical. Acute bronchiolitis and pneumonia were the most frequent causes of hospitalization among severe cases. Twenty-seven hospitalized children fulfilled the diagnostic criteria for multisystem inflammatory syndrome (median age: 29 months; 85.2% non-severe). Significant coexisting condition was present in 29% of hospitalized children. Risk of hospitalization was higher in children with ≥1 comorbidity, age <2 years, or obesity. Increased risk of severe disease was described among those with leucopenia, leukocytosis, or any significant comorbidity. No deaths occurred.
Conclusion: : Though most children with COVID-19 experienced mild disease and no deaths occurred, a significant proportion required hospitalization and developed severe illness. Obesity, young age, underlying comorbidity, leucopenia, and leukocytosis were risk factors for hospitalization or severe disease.
Keywords: Brazil; COVID-19; MIS-C; PIMS-TS; Pediatric; SARS-CoV-2; hospital-based surveillance.
. 2022 Dec 15.
doi: 10.1016/j.ijregi.2022.12.003. Online ahead of print.
Characteristics and clinical outcomes of COVID-19 in children: A hospital-based surveillance study in Latin America's hardest-hit city
Daniel Jarovsky[SUP] 1 2 [/SUP], Giuliana de Freitas Fongaro[SUP] 1 [/SUP], Renata Mazzotti Zampol[SUP] 1 [/SUP], Thales Araújo de Oliveira[SUP] 1 [/SUP], Camila Giuliana Almeida Farias[SUP] 1 [/SUP], Daniella Gregória Bomfim Prado da Silva[SUP] 1 [/SUP], Denis Tadeu Gomes Cavalcante[SUP] 1 [/SUP], Sabrina Bortolin Nery[SUP] 1 [/SUP], José Cassio de Moraes[SUP] 2 [/SUP], Francisco Ivanildo de Oliveira Junior[SUP] 1 [/SUP], Flávia Jacqueline Almeida[SUP] 1 2 [/SUP], Marco Aurélio Palazzi Sáfadi[SUP] 1 2 [/SUP]
Affiliations
- PMID: 36536932
- PMCID: PMC9753484
- DOI: 10.1016/j.ijregi.2022.12.003
Abstract
Background: : In 2020, Brazil became the coronavirus disease (COVID-19) pandemic's epicenter in Latin America, resulting in an unparalleled health catastrophe. Nevertheless, comprehensive clinical reports in Brazilian children are unavailable.
Methods: : This retrospective, hospital-based, active-surveillance study was performed to identify pediatric patients with COVID-19 presenting at a private academic medical center in a large urban area between March 2020 and March 2021. Clinical and demographic information was analyzed among those requiring hospitalization, those with severe illness, and those with clinical syndromes.
Results 964 cases of symptomatic conditions were evaluated: : 17.7% required hospitalization, 27.5% of which were classified as severe/critical. Acute bronchiolitis and pneumonia were the most frequent causes of hospitalization among severe cases. Twenty-seven hospitalized children fulfilled the diagnostic criteria for multisystem inflammatory syndrome (median age: 29 months; 85.2% non-severe). Significant coexisting condition was present in 29% of hospitalized children. Risk of hospitalization was higher in children with ≥1 comorbidity, age <2 years, or obesity. Increased risk of severe disease was described among those with leucopenia, leukocytosis, or any significant comorbidity. No deaths occurred.
Conclusion: : Though most children with COVID-19 experienced mild disease and no deaths occurred, a significant proportion required hospitalization and developed severe illness. Obesity, young age, underlying comorbidity, leucopenia, and leukocytosis were risk factors for hospitalization or severe disease.
Keywords: Brazil; COVID-19; MIS-C; PIMS-TS; Pediatric; SARS-CoV-2; hospital-based surveillance.