Mingus
Well-known member
I saw this article pass-by the other day at the office.
While everyone's eye is stick on H5N1, H2N3 may hit tomorrow, who nows ? ( sorry for the bad taste humor. )
By the way, hello to everyone here, long-time no see:tiphat:
- Mingus
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1: Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20949-54. Epub 2007 Dec 18.
Identification of H2N3 influenza A viruses from swine in the United States.
<!--AuthorList-->Ma W, Vincent AL, Gramer MR, Brockwell CB, Lager KM, Janke BH, Gauger PC, Patnayak DP, Webby RJ, Richt JA.
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
Although viruses of each of the 16 influenza A HA subtypes are potential human pathogens, only viruses of the H1, H2, and H3 subtype are known to have been successfully established in humans. H2 influenza viruses have been absent from human circulation since 1968, and as such they pose a substantial human pandemic risk. In this report, we isolate and characterize genetically similar avian/swine virus reassortant H2N3 influenza A viruses isolated from diseased swine from two farms in the United States. These viruses contained leucine at position 226 of the H2 protein, which has been associated with increased binding affinity to the mammalian alpha2,6Gal-linked sialic acid virus receptor. Correspondingly, the H2N3 viruses were able to cause disease in experimentally infected swine and mice without prior adaptation. In addition, the swine H2N3 virus was infectious and highly transmissible in swine and ferrets. Taken together, these findings suggest that the H2N3 virus has undergone some adaptation to the mammalian host and that their spread should be very closely monitored.
PMID: 18093945 [PubMed - in process]
While everyone's eye is stick on H5N1, H2N3 may hit tomorrow, who nows ? ( sorry for the bad taste humor. )
By the way, hello to everyone here, long-time no see:tiphat:
- Mingus
_____________________________________________________________
1: Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20949-54. Epub 2007 Dec 18.
Identification of H2N3 influenza A viruses from swine in the United States.
<!--AuthorList-->Ma W, Vincent AL, Gramer MR, Brockwell CB, Lager KM, Janke BH, Gauger PC, Patnayak DP, Webby RJ, Richt JA.
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
Although viruses of each of the 16 influenza A HA subtypes are potential human pathogens, only viruses of the H1, H2, and H3 subtype are known to have been successfully established in humans. H2 influenza viruses have been absent from human circulation since 1968, and as such they pose a substantial human pandemic risk. In this report, we isolate and characterize genetically similar avian/swine virus reassortant H2N3 influenza A viruses isolated from diseased swine from two farms in the United States. These viruses contained leucine at position 226 of the H2 protein, which has been associated with increased binding affinity to the mammalian alpha2,6Gal-linked sialic acid virus receptor. Correspondingly, the H2N3 viruses were able to cause disease in experimentally infected swine and mice without prior adaptation. In addition, the swine H2N3 virus was infectious and highly transmissible in swine and ferrets. Taken together, these findings suggest that the H2N3 virus has undergone some adaptation to the mammalian host and that their spread should be very closely monitored.
PMID: 18093945 [PubMed - in process]
