tetano
Editor, Senior Moderator
Bioorg Med Chem Lett. 2019 Feb 26. pii: S0960-894X(19)30111-8. doi: 10.1016/j.bmcl.2019.02.027. [Epub ahead of print]
[h=1]Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists.[/h] Patnaik S[SUP]1[/SUP], Basu D[SUP]2[/SUP], Southall N[SUP]3[/SUP], Dehdashti S[SUP]3[/SUP], Wan KK[SUP]3[/SUP], Zheng W[SUP]3[/SUP], Ferrer M[SUP]3[/SUP], Taylor M[SUP]3[/SUP], Engel DA[SUP]4[/SUP], Marugan JJ[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Nonstructural protein 1 (NS1) plays a crucial function in the replication, spread, and pathogenesis of influenza virus by inhibiting the host innate immune response. Here we report the discovery and optimization of novel pyrazolopyridine NS1 antagonists that can potently inhibit influenza A/PR/8/34 replication in MDCK cells, rescue MDCK cells from cytopathic effects of seasonal influenza A strains, reverse NS1-dependent inhibition of IFN-β gene expression, and suppress the slow growth phenotype in NS1-expressing yeast. These pyrazolopyridines will enable researchers to investigate NS1 function during infection and how antagonists can be utilized in the next generation of treatments for influenza infection.
Copyright ? 2019 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Antagonist; Antiviral; Influenza; NS1; Pyrazolopyridine
PMID: 30852083 DOI: 10.1016/j.bmcl.2019.02.027
[h=1]Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists.[/h] Patnaik S[SUP]1[/SUP], Basu D[SUP]2[/SUP], Southall N[SUP]3[/SUP], Dehdashti S[SUP]3[/SUP], Wan KK[SUP]3[/SUP], Zheng W[SUP]3[/SUP], Ferrer M[SUP]3[/SUP], Taylor M[SUP]3[/SUP], Engel DA[SUP]4[/SUP], Marugan JJ[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Nonstructural protein 1 (NS1) plays a crucial function in the replication, spread, and pathogenesis of influenza virus by inhibiting the host innate immune response. Here we report the discovery and optimization of novel pyrazolopyridine NS1 antagonists that can potently inhibit influenza A/PR/8/34 replication in MDCK cells, rescue MDCK cells from cytopathic effects of seasonal influenza A strains, reverse NS1-dependent inhibition of IFN-β gene expression, and suppress the slow growth phenotype in NS1-expressing yeast. These pyrazolopyridines will enable researchers to investigate NS1 function during infection and how antagonists can be utilized in the next generation of treatments for influenza infection.
Copyright ? 2019 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Antagonist; Antiviral; Influenza; NS1; Pyrazolopyridine
PMID: 30852083 DOI: 10.1016/j.bmcl.2019.02.027