tetano
Editor, Senior Moderator
IDCases
. 2024 Aug 22:37:e02066.
doi: 10.1016/j.idcr.2024.e02066. eCollection 2024. Necrotizing pneumonia secondary to Influenza A (H1N1) coinfection with Staphylococcus aureus: A case report
Huibin Chen[SUP] 1 [/SUP], Hui Duan[SUP] 1 [/SUP], Jinling Zhao[SUP] 1 [/SUP], Kang Sun[SUP] 1 [/SUP], Keji Shan[SUP] 1 [/SUP]
Affiliations
Objective: This study aims to enhance understanding of necrotizing pneumonia and toxic shock syndrome by analyzing an adult case of community-acquired necrotizing pneumonia caused by co-infection of Influenza A (H1N1) and Staphylococcus aureus with LukS-PV and LukF-PV virulence factor genes.
Method: The clinical data of one patient admitted to the intensive care unit (ICU) with co-infection of Influenza A (H1N1) and Staphylococcus aureus was retrospectively analyzed.
Results: The patient exhibited typical clinical manifestations of viral and Staphylococcus aureus co-infection, including necrotizing pneumonia and toxic shock syndrome. The presence of LukS-PV and LukF-PV virulence factor genes of Staphylococcus aureus was detected in the patient's bronchoalveolar lavage fluid. Unfortunately，although antiviral agents (oseltamivir) and antibiotics (linezolid, imipenem-cilastatin) were timely administrated, as well as corticosteroids for anti-inflammatory purposes, the patient's condition was progressively deteriorated and eventually led to death.
Conclusion: Clinical practitioners should be vigilant about the co-infection of Influenza virus and Staphylococcus aureus, particularly when the latter carries virulence factors. The presence of virulence factor genes of Staphylococcus aureus can lead to necrotizing pneumonia with a poor prognosis. This is a particular concern because both infections can be life threatening in young adults.
Keywords: Co-infection; Influenza A virus (H1N1); LukF and LukS genes; Necrotizing pneumonia; Panton–Valentine leukocidin (PVL)-producing Staphylococcus aureus; Pneumonia; Toxic shock syndrome.
. 2024 Aug 22:37:e02066.
doi: 10.1016/j.idcr.2024.e02066. eCollection 2024. Necrotizing pneumonia secondary to Influenza A (H1N1) coinfection with Staphylococcus aureus: A case report
Huibin Chen[SUP] 1 [/SUP], Hui Duan[SUP] 1 [/SUP], Jinling Zhao[SUP] 1 [/SUP], Kang Sun[SUP] 1 [/SUP], Keji Shan[SUP] 1 [/SUP]
Affiliations
- PMID: 39263669
- PMCID: PMC11388272
- DOI: 10.1016/j.idcr.2024.e02066
Objective: This study aims to enhance understanding of necrotizing pneumonia and toxic shock syndrome by analyzing an adult case of community-acquired necrotizing pneumonia caused by co-infection of Influenza A (H1N1) and Staphylococcus aureus with LukS-PV and LukF-PV virulence factor genes.
Method: The clinical data of one patient admitted to the intensive care unit (ICU) with co-infection of Influenza A (H1N1) and Staphylococcus aureus was retrospectively analyzed.
Results: The patient exhibited typical clinical manifestations of viral and Staphylococcus aureus co-infection, including necrotizing pneumonia and toxic shock syndrome. The presence of LukS-PV and LukF-PV virulence factor genes of Staphylococcus aureus was detected in the patient's bronchoalveolar lavage fluid. Unfortunately，although antiviral agents (oseltamivir) and antibiotics (linezolid, imipenem-cilastatin) were timely administrated, as well as corticosteroids for anti-inflammatory purposes, the patient's condition was progressively deteriorated and eventually led to death.
Conclusion: Clinical practitioners should be vigilant about the co-infection of Influenza virus and Staphylococcus aureus, particularly when the latter carries virulence factors. The presence of virulence factor genes of Staphylococcus aureus can lead to necrotizing pneumonia with a poor prognosis. This is a particular concern because both infections can be life threatening in young adults.
Keywords: Co-infection; Influenza A virus (H1N1); LukF and LukS genes; Necrotizing pneumonia; Panton–Valentine leukocidin (PVL)-producing Staphylococcus aureus; Pneumonia; Toxic shock syndrome.