tetano
Editor, Senior Moderator
IDCases
. 2022;27:e01446.
doi: 10.1016/j.idcr.2022.e01446. Epub 2022 Feb 7.
Intravenous veterinary ivermectin in a COVID-19 patient causing neurotoxicity
Stefan Porubcin[SUP] 1 2 [/SUP], Alena Rovnakova[SUP] 1 [/SUP], Ondrej Zahornacky[SUP] 1 2 [/SUP], Pavol Jarcuska[SUP] 1 2 [/SUP]
Affiliations
Abstract
Ivermectin administration for Coronavirus disease 2019 (COVID-19) infection has gained a lot of attention recently. Although ivermectin has a relatively good safety profile, serious adverse events may occur in patients given doses that are presumed experimental. Ivermectin for human use is available only as an oral formulation. Parenteral administration, as a subcutaneous injection, is possible in veterinary medicine only. In this brief report we describe an unprecedented case of a patient with severe neurotoxicity after intravenous administration of veterinary ivermectin for confirmed COVID-19 infection. The patient required hospitalization in the intensive care unit (ICU). The toxic serum concentration of ivermectin was determined by liquid chromatography/mass spectrometry - time of flight (LC/MS-TOF) with the value of 187.74 ng/mL.
Keywords: COVID-19; Ivermectin; Neurotoxicity.
. 2022;27:e01446.
doi: 10.1016/j.idcr.2022.e01446. Epub 2022 Feb 7.
Intravenous veterinary ivermectin in a COVID-19 patient causing neurotoxicity
Stefan Porubcin[SUP] 1 2 [/SUP], Alena Rovnakova[SUP] 1 [/SUP], Ondrej Zahornacky[SUP] 1 2 [/SUP], Pavol Jarcuska[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35155125
- PMCID: PMC8818555
- DOI: 10.1016/j.idcr.2022.e01446
Abstract
Ivermectin administration for Coronavirus disease 2019 (COVID-19) infection has gained a lot of attention recently. Although ivermectin has a relatively good safety profile, serious adverse events may occur in patients given doses that are presumed experimental. Ivermectin for human use is available only as an oral formulation. Parenteral administration, as a subcutaneous injection, is possible in veterinary medicine only. In this brief report we describe an unprecedented case of a patient with severe neurotoxicity after intravenous administration of veterinary ivermectin for confirmed COVID-19 infection. The patient required hospitalization in the intensive care unit (ICU). The toxic serum concentration of ivermectin was determined by liquid chromatography/mass spectrometry - time of flight (LC/MS-TOF) with the value of 187.74 ng/mL.
Keywords: COVID-19; Ivermectin; Neurotoxicity.