tetano
Editor, Senior Moderator
Vet Microbiol. 2013 Feb 8. pii: S0378-1135(13)00096-5. doi: 10.1016/j.vetmic.2013.01.044. [Epub ahead of print]
Emergence of influenza viruses with zoonotic potential: Open issues which need to be addressed. A review.
Capua I, Munoz O.
Source
Istituto Zooprofilattico Sperimentale delle Venezie, OIE/FAO and National Reference Laboratory for Newcastle Disease and Avian Influenza, OIE Collaborating Centre for Diseases at the Human-Animal Interface, Viale dell'Universit? 10, 35020, Legnaro, Padova, Italy. Electronic address: icapua@izsvenezie.it.
Abstract
The real and perceived impact of influenza infections in animals has changed dramatically over the last 10 years, due mainly to the better understanding of the public health implications of avian and swine influenza viruses. On a number of occasions in the last decade avian-to-human transmissions of H5, H7 and H9 virus subtypes have occurred, and the first influenza pandemic of the new millennium occurred as a result of the emergence and spread of a virus from pigs. Although the mechanisms that allow influenza viruses to jump from one host species to another are not fully understood, several genetic signatures linked to the crossing of species barriers have been identified. This has led to a re-evaluation of the importance of understanding these viruses in the animal reservoir, to the extent that millions of euros have been invested in surveillance, research and capacity building worldwide. This has resulted in an enhanced collaboration with our medical counterparts, leading to many discoveries that will contribute to an understanding of the complex mechanisms that lead to the emergence of a pandemic virus.
Copyright ? 2013 Elsevier B.V. All rights reserved.
PMID:
23567150
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23567150
Emergence of influenza viruses with zoonotic potential: Open issues which need to be addressed. A review.
Capua I, Munoz O.
Source
Istituto Zooprofilattico Sperimentale delle Venezie, OIE/FAO and National Reference Laboratory for Newcastle Disease and Avian Influenza, OIE Collaborating Centre for Diseases at the Human-Animal Interface, Viale dell'Universit? 10, 35020, Legnaro, Padova, Italy. Electronic address: icapua@izsvenezie.it.
Abstract
The real and perceived impact of influenza infections in animals has changed dramatically over the last 10 years, due mainly to the better understanding of the public health implications of avian and swine influenza viruses. On a number of occasions in the last decade avian-to-human transmissions of H5, H7 and H9 virus subtypes have occurred, and the first influenza pandemic of the new millennium occurred as a result of the emergence and spread of a virus from pigs. Although the mechanisms that allow influenza viruses to jump from one host species to another are not fully understood, several genetic signatures linked to the crossing of species barriers have been identified. This has led to a re-evaluation of the importance of understanding these viruses in the animal reservoir, to the extent that millions of euros have been invested in surveillance, research and capacity building worldwide. This has resulted in an enhanced collaboration with our medical counterparts, leading to many discoveries that will contribute to an understanding of the complex mechanisms that lead to the emergence of a pandemic virus.
Copyright ? 2013 Elsevier B.V. All rights reserved.
PMID:
23567150
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23567150