tetano
Editor, Senior Moderator
J Gen Virol. 2012 Nov 14. [Epub ahead of print]
Human T cells directed to seasonal influenza A virus cross-react with A(H1N1)pdm09 and swine origin triple reassortant H3N2 influenza viruses.
Hillaire ML, Vogelzang-van Trierum SE, Kreijtz JH, de Mutsert G, Fouchier RA, Osterhaus AD, Rimmelzwaan GF.
Source
Erasmus MC.
Abstract
Virus-specific CD8+ T cells contribute to protective immunity against influenza A virus infections. Since the majority of these cells are directed to conserved viral proteins, they may afford protection against influenza A viruses of various subtypes. In the present study, we assessed the cross-reactivity of human CD8+ T lymphocytes, induced by infection with seasonal A(H1N1) or A(H3N2) influenza viruses, with 2009 pandemic influenza A/H1N1 virus (A(H1N1)pdm09) and swine origin triple reassortant A(H3N2) (A(H3N2)v) viruses that currently cause an increasing number of human cases in the USA. We demonstrated that CD8+ T cells induced after seasonal influenza A virus infections exert lytic activity and produce IFN-γ upon in vitro restimulation with A(H1N1)pdm09 and A(H3N2)v influenza A viruses. Furthermore, CD8+ T cells directed to A(H1N1)pdm09 virus displayed a high degree of cross-reactivity with A(H3N2)v viruses. It was concluded that cross-reacting T cells have the potential to afford protective immunity against A(H1N1)pdm09 viruses during the pandemic and offer some degree of protection against infection with A(H3N2)v viruses.
PMID:
23152369
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23152369
Human T cells directed to seasonal influenza A virus cross-react with A(H1N1)pdm09 and swine origin triple reassortant H3N2 influenza viruses.
Hillaire ML, Vogelzang-van Trierum SE, Kreijtz JH, de Mutsert G, Fouchier RA, Osterhaus AD, Rimmelzwaan GF.
Source
Erasmus MC.
Abstract
Virus-specific CD8+ T cells contribute to protective immunity against influenza A virus infections. Since the majority of these cells are directed to conserved viral proteins, they may afford protection against influenza A viruses of various subtypes. In the present study, we assessed the cross-reactivity of human CD8+ T lymphocytes, induced by infection with seasonal A(H1N1) or A(H3N2) influenza viruses, with 2009 pandemic influenza A/H1N1 virus (A(H1N1)pdm09) and swine origin triple reassortant A(H3N2) (A(H3N2)v) viruses that currently cause an increasing number of human cases in the USA. We demonstrated that CD8+ T cells induced after seasonal influenza A virus infections exert lytic activity and produce IFN-γ upon in vitro restimulation with A(H1N1)pdm09 and A(H3N2)v influenza A viruses. Furthermore, CD8+ T cells directed to A(H1N1)pdm09 virus displayed a high degree of cross-reactivity with A(H3N2)v viruses. It was concluded that cross-reacting T cells have the potential to afford protective immunity against A(H1N1)pdm09 viruses during the pandemic and offer some degree of protection against infection with A(H3N2)v viruses.
PMID:
23152369
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23152369