Giuseppe
Emeritus
Human Infection with Highly Pathogenic Avian Influenza Virus (H5N1) in Northern Vietnam, 2004?2005 [US CDC EID]
EMERGING INFECTIOUS DISEASES REVIEW
DOI: 10.3201/eid1501.080073
Full text (PDF) LINK
Suggested citation for this article: Hien ND, Ha NH, Van NT, Ha NTM, Lien TTM, Thai NQ, et al. Human infection with highly pathogenic avian influenza virus (H5N1) in northern Vietnam, 2004?2005. Emerg Infect Dis. 2009 Jan; [Epub ahead of print]
Human Infection with Highly Pathogenic Avian Influenza Virus (H5N1) in Northern Vietnam, 2004?2005
Nguyen Duc Hien, Nguyen Hong Ha, Nguyen Tuong Van, Nguyen Thi Minh Ha, Trinh Thi Minh Lien, Nguyen Quoc Thai, Van Dinh Trang, Takuro Shimbo, Yoshimitsu Takahashi, Yasuyuki Kato, Akihiko Kawana, Samu Akita, and Koichiro Kudo
Author affiliations: National Institute of Infectious and Tropical Diseases, Hanoi, Vietnam (N.D. Hien, N.H. Ha, N.T. Van, N.T.M. Ha, T.T.M. Lien, N.Q. Thai, V.D. Trang); and International Medical Center of Japan, Tokyo, Japan (T. Shimbo, Y. Takahashi, Y. Kato, A. Kawana, S. Akita, K. Kudo)
We performed a retrospective case-series study of patients with influenza A (H5N1) admitted to the National Institute of Infectious and Tropical Diseases in Hanoi, Vietnam, from January 2004 through July 2005 with symptoms of acute respiratory tract infection; a history of high-risk exposure or chest radiographic findings such as pneumonia; and positive findings for A/H5 viral RNA by reverse transcription?PCR.
We investigated data from 29 patients (mean age 35.1 years) of whom 7 (24.1%) had died.
Mortality rates were 20% (5/25) and 50% (2/4) among patients treated with or without oseltamivir (p = 0.24), respectively, and were 33.3% (5/15) and 14.2% (2/14) among patients treated with and without methylprednisolone (p = 0.39), respectively.
After exact logistic regression analysis was adjusted for variation in severity, no significant effectiveness for survival was observed among patients treated with oseltamivir or methylprednisolone.
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EMERGING INFECTIOUS DISEASES REVIEW
DOI: 10.3201/eid1501.080073
Full text (PDF) LINK
Suggested citation for this article: Hien ND, Ha NH, Van NT, Ha NTM, Lien TTM, Thai NQ, et al. Human infection with highly pathogenic avian influenza virus (H5N1) in northern Vietnam, 2004?2005. Emerg Infect Dis. 2009 Jan; [Epub ahead of print]
Human Infection with Highly Pathogenic Avian Influenza Virus (H5N1) in Northern Vietnam, 2004?2005
Nguyen Duc Hien, Nguyen Hong Ha, Nguyen Tuong Van, Nguyen Thi Minh Ha, Trinh Thi Minh Lien, Nguyen Quoc Thai, Van Dinh Trang, Takuro Shimbo, Yoshimitsu Takahashi, Yasuyuki Kato, Akihiko Kawana, Samu Akita, and Koichiro Kudo
Author affiliations: National Institute of Infectious and Tropical Diseases, Hanoi, Vietnam (N.D. Hien, N.H. Ha, N.T. Van, N.T.M. Ha, T.T.M. Lien, N.Q. Thai, V.D. Trang); and International Medical Center of Japan, Tokyo, Japan (T. Shimbo, Y. Takahashi, Y. Kato, A. Kawana, S. Akita, K. Kudo)
We performed a retrospective case-series study of patients with influenza A (H5N1) admitted to the National Institute of Infectious and Tropical Diseases in Hanoi, Vietnam, from January 2004 through July 2005 with symptoms of acute respiratory tract infection; a history of high-risk exposure or chest radiographic findings such as pneumonia; and positive findings for A/H5 viral RNA by reverse transcription?PCR.
We investigated data from 29 patients (mean age 35.1 years) of whom 7 (24.1%) had died.
Mortality rates were 20% (5/25) and 50% (2/4) among patients treated with or without oseltamivir (p = 0.24), respectively, and were 33.3% (5/15) and 14.2% (2/14) among patients treated with and without methylprednisolone (p = 0.39), respectively.
After exact logistic regression analysis was adjusted for variation in severity, no significant effectiveness for survival was observed among patients treated with oseltamivir or methylprednisolone.
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