Mary Wilson
Well-known member
Published January 8, 2025
DOI: 10.1056/NEJMc2410853
TO THE EDITOR:
The continuous emergence and reemergence of tickborne diseases have presented an increasing threat to human health.[SUP]1,2[/SUP]We conducted an active surveillance of febrile patients with recent tick bites at a sentinel hospital in northeastern China to identify potential causative agents. All the participants provided written or oral informed consent, and the study protocol was approved by the ethics committee at Mudanjiang Forestry Central Hospital.
We performed metatranscriptomic sequencing of serum samples obtained from 252 febrile patients from May through July in 2023. We also used de novo assembly to create the genomes of an unknown virus identified in serum samples obtained from 2 patients. Phylogenomic analyses revealed that the virus belonged to the orthonairovirus genus of the Nairoviridae family (Figure 1A, 1B, and 1C) but shared less than 75.6% amino acid identity of RNA-dependent RNA polymerase protein with all known orthonairovirus members, indicating a new species.[SUP]3[/SUP] ...
https://www.nejm.org/doi/full/10.1056/NEJMc2410853
DOI: 10.1056/NEJMc2410853
TO THE EDITOR:
The continuous emergence and reemergence of tickborne diseases have presented an increasing threat to human health.[SUP]1,2[/SUP]We conducted an active surveillance of febrile patients with recent tick bites at a sentinel hospital in northeastern China to identify potential causative agents. All the participants provided written or oral informed consent, and the study protocol was approved by the ethics committee at Mudanjiang Forestry Central Hospital.
We performed metatranscriptomic sequencing of serum samples obtained from 252 febrile patients from May through July in 2023. We also used de novo assembly to create the genomes of an unknown virus identified in serum samples obtained from 2 patients. Phylogenomic analyses revealed that the virus belonged to the orthonairovirus genus of the Nairoviridae family (Figure 1A, 1B, and 1C) but shared less than 75.6% amino acid identity of RNA-dependent RNA polymerase protein with all known orthonairovirus members, indicating a new species.[SUP]3[/SUP] ...
https://www.nejm.org/doi/full/10.1056/NEJMc2410853