tetano
Editor, Senior Moderator
Hum Vaccin Immunother
. 2022 Apr 22;1-7.
doi: 10.1080/21645515.2022.2064134. Online ahead of print.
Self-Reported adverse events among Chinese healthcare workers immunized with COVID-19 vaccines composed of inactivated SARS-CoV-2
Yandong Cheng[SUP] 1 [/SUP], Taishun Li[SUP] 2 [/SUP], Yaning Zheng[SUP] 3 [/SUP], Biyun Xu[SUP] 2 [/SUP], Yan Bi[SUP] 1 [/SUP], Yali Hu[SUP] 3 [/SUP], Yi-Hua Zhou[SUP] 4 5 [/SUP]
Affiliations
Abstract
Mass vaccination is critical to control the pandemic of coronavirus disease 2019 (COVID-19). Fear of adverse events (AEs) after COVID-19 vaccination is a main factor associated with vaccination hesitancy. We aimed to analyze AEs in healthcare workers (HCWs) vaccinated with COVID-19 vaccines (Aikewei or CoronaVac) composed of inactivated virus. We used a structured self-administered questionnaire to conduct two surveys on COVID-19 vaccination among HCWs in perinatal medicine and obstetrics/gynecology from April 5 to April 21, 2021. In total, 1392 HCWs who had received at least one vaccine dose were included. Of them, 1264 (90.8%) were females and 1047 (75.2%) received two doses. The overall incidence of any AEs after the first and second dose was 38.2% (532/1392) and 31.0% (325/1047) respectively (χ2 = 13.506, P = .0002). Female and HCWs aged 18-30 y were more likely to report AEs. The most common AEs were local reaction, accounting for 48.1% and 67.4% of all AEs after the first and second dose respectively. The systemic AEs were mainly neurological (9.8% and 4.8% after the first and second injection respectively) and flu-like symptoms (6.3% and 3.2%). Overall, most of AEs were mild, only 5.1% (after the first dose) and 2.8% (after the second dose) of individuals with AEs received symptomatic treatment or sick leaves, and none of them required hospitalization. Our data added more evidence that inactivated COVID-19 vaccines are highly safe. The data are valuable to overcome vaccine hesitancy associated with concerns about the safety of COVID-19 vaccines.
Keywords: COVID-19; adverse events; healthcare workers; inactivated SARS-CoV-2; vaccination.
. 2022 Apr 22;1-7.
doi: 10.1080/21645515.2022.2064134. Online ahead of print.
Self-Reported adverse events among Chinese healthcare workers immunized with COVID-19 vaccines composed of inactivated SARS-CoV-2
Yandong Cheng[SUP] 1 [/SUP], Taishun Li[SUP] 2 [/SUP], Yaning Zheng[SUP] 3 [/SUP], Biyun Xu[SUP] 2 [/SUP], Yan Bi[SUP] 1 [/SUP], Yali Hu[SUP] 3 [/SUP], Yi-Hua Zhou[SUP] 4 5 [/SUP]
Affiliations
- PMID: 35452357
- DOI: 10.1080/21645515.2022.2064134
Abstract
Mass vaccination is critical to control the pandemic of coronavirus disease 2019 (COVID-19). Fear of adverse events (AEs) after COVID-19 vaccination is a main factor associated with vaccination hesitancy. We aimed to analyze AEs in healthcare workers (HCWs) vaccinated with COVID-19 vaccines (Aikewei or CoronaVac) composed of inactivated virus. We used a structured self-administered questionnaire to conduct two surveys on COVID-19 vaccination among HCWs in perinatal medicine and obstetrics/gynecology from April 5 to April 21, 2021. In total, 1392 HCWs who had received at least one vaccine dose were included. Of them, 1264 (90.8%) were females and 1047 (75.2%) received two doses. The overall incidence of any AEs after the first and second dose was 38.2% (532/1392) and 31.0% (325/1047) respectively (χ2 = 13.506, P = .0002). Female and HCWs aged 18-30 y were more likely to report AEs. The most common AEs were local reaction, accounting for 48.1% and 67.4% of all AEs after the first and second dose respectively. The systemic AEs were mainly neurological (9.8% and 4.8% after the first and second injection respectively) and flu-like symptoms (6.3% and 3.2%). Overall, most of AEs were mild, only 5.1% (after the first dose) and 2.8% (after the second dose) of individuals with AEs received symptomatic treatment or sick leaves, and none of them required hospitalization. Our data added more evidence that inactivated COVID-19 vaccines are highly safe. The data are valuable to overcome vaccine hesitancy associated with concerns about the safety of COVID-19 vaccines.
Keywords: COVID-19; adverse events; healthcare workers; inactivated SARS-CoV-2; vaccination.