tetano
Editor, Senior Moderator
Hum Vaccin Immunother
. 2024 Dec 31;20(1):2380111.
doi: 10.1080/21645515.2024.2380111. Epub 2024 Aug 29. Neutralization potency of the 2023-24 seasonal influenza vaccine against circulating influenza H3N2 strains
Xiande Huang[SUP] 1 [/SUP], Ziqi Cheng[SUP] 1 [/SUP], Yake Lv[SUP] 2 [/SUP], Weixuan Li[SUP] 2 [/SUP], Xiaoyu Liu[SUP] 2 [/SUP], Weijin Huang[SUP] 1 [/SUP], Chenyan Zhao[SUP] 1 [/SUP]
Affiliations
Seasonal influenza is a severe disease that significantly impacts public health, causing millions of infections and hundreds of thousands of deaths each year. Seasonal influenza viruses, particularly the H3N2 subtype, exhibit high antigenic variability, often leading to mismatch between vaccine strains and circulating strains. Therefore, rapidly assessing the alignment between existing seasonal influenza vaccine and circulating strains is crucial for enhancing vaccine efficacy. This study, based on a pseudovirus platform, evaluated the match between current influenza H3N2 vaccine strains and circulating strains through cross-neutralization assays using clinical human immune sera against globally circulating influenza virus strains. The research results show that although mutations are present in the circulating strains, the current H3N2 vaccine strain still imparting effective protection, providing a scientific basis for encouraging influenza vaccination. This research methodology can be sustainably applied for the neutralization potency assessment of subsequent circulating strains, establishing a persistent methodological framework.
Keywords: H3N2; Influenza virus; neutralization assay; pseudovirus; vaccine.
. 2024 Dec 31;20(1):2380111.
doi: 10.1080/21645515.2024.2380111. Epub 2024 Aug 29. Neutralization potency of the 2023-24 seasonal influenza vaccine against circulating influenza H3N2 strains
Xiande Huang[SUP] 1 [/SUP], Ziqi Cheng[SUP] 1 [/SUP], Yake Lv[SUP] 2 [/SUP], Weixuan Li[SUP] 2 [/SUP], Xiaoyu Liu[SUP] 2 [/SUP], Weijin Huang[SUP] 1 [/SUP], Chenyan Zhao[SUP] 1 [/SUP]
Affiliations
- PMID: 39205645
- DOI: 10.1080/21645515.2024.2380111
Seasonal influenza is a severe disease that significantly impacts public health, causing millions of infections and hundreds of thousands of deaths each year. Seasonal influenza viruses, particularly the H3N2 subtype, exhibit high antigenic variability, often leading to mismatch between vaccine strains and circulating strains. Therefore, rapidly assessing the alignment between existing seasonal influenza vaccine and circulating strains is crucial for enhancing vaccine efficacy. This study, based on a pseudovirus platform, evaluated the match between current influenza H3N2 vaccine strains and circulating strains through cross-neutralization assays using clinical human immune sera against globally circulating influenza virus strains. The research results show that although mutations are present in the circulating strains, the current H3N2 vaccine strain still imparting effective protection, providing a scientific basis for encouraging influenza vaccination. This research methodology can be sustainably applied for the neutralization potency assessment of subsequent circulating strains, establishing a persistent methodological framework.
Keywords: H3N2; Influenza virus; neutralization assay; pseudovirus; vaccine.