tetano
Editor, Senior Moderator
Hum Vaccin Immunother
. 2024 Dec 31;20(1):2424615.
doi: 10.1080/21645515.2024.2424615. Epub 2024 Nov 13. Medium-term immunogenicity of three doses of BNT162b2 and CoronaVac in Hong Kong neuromuscular disease patients
Michael Kwan Leung Yu[SUP] 1 [/SUP], Sophelia Hoi Shan Chan[SUP] 1 [/SUP], Daniel Leung[SUP] 1 [/SUP], Samuel Cheng[SUP] 2 [/SUP], Leo Chi Hang Tsang[SUP] 2 [/SUP], Tsz Chun Kwan[SUP] 2 [/SUP], Kaiyue Zhang[SUP] 1 [/SUP], Xiwei Wang[SUP] 1 [/SUP], Wenwei Tu[SUP] 1 [/SUP], Malik Peiris[SUP] 2 [/SUP], Yu Lung Lau[SUP] 1 [/SUP], Jaime S Rosa Duque[SUP] 1 [/SUP]
Affiliations
The durability of the immunogenicity elicited by three doses of mRNA-based BNT162b2 and whole-virus inactivated CoronaVac in patients with neuromuscular diseases, particularly those on immunosuppressive drugs and variants of concern, has not been well-established. Our goal was to evaluate medium-term humoral immunogenicity outcomes after 3 doses of these vaccines. Peripheral blood samples were collected from participants 14-49 days and 155-210 days after administration of the third vaccine dose to assess humoral immune responses through serological assays. The immunogenicity outcomes of each patient were compared to those of three age-matched healthy control participants, ensuring a balanced comparison. Both patients that received 3 doses of BNT162b2 and 10 (90.9%) patients that received CoronaVac seroconverted against wild-type-SARS-CoV-2 virus, showing comparable antibody responses to healthy participants. After 6 months, one patient in BNT162b2 and all four patients in CoronaVac groups maintained seropositivity. The JN-1 specific binding antibody response was lower compared to wild-type virus. The use of corticosteroids did not affect seroconversion rate against wild-type virus or JN.1 variant. BNT162b2 and CoronaVac were immunogenic for neuromuscular diseases patients, maintaining durability after 6 months even for those on corticosteroids. Our data support a rapid immunization series utilizing mRNA-based and whole-virus inactivated vaccines for future pandemic.
Keywords: BNT162b2; COVID-19; CoronaVac; immunogenicity; neuromuscular diseases.
. 2024 Dec 31;20(1):2424615.
doi: 10.1080/21645515.2024.2424615. Epub 2024 Nov 13. Medium-term immunogenicity of three doses of BNT162b2 and CoronaVac in Hong Kong neuromuscular disease patients
Michael Kwan Leung Yu[SUP] 1 [/SUP], Sophelia Hoi Shan Chan[SUP] 1 [/SUP], Daniel Leung[SUP] 1 [/SUP], Samuel Cheng[SUP] 2 [/SUP], Leo Chi Hang Tsang[SUP] 2 [/SUP], Tsz Chun Kwan[SUP] 2 [/SUP], Kaiyue Zhang[SUP] 1 [/SUP], Xiwei Wang[SUP] 1 [/SUP], Wenwei Tu[SUP] 1 [/SUP], Malik Peiris[SUP] 2 [/SUP], Yu Lung Lau[SUP] 1 [/SUP], Jaime S Rosa Duque[SUP] 1 [/SUP]
Affiliations
- PMID: 39539036
- DOI: 10.1080/21645515.2024.2424615
The durability of the immunogenicity elicited by three doses of mRNA-based BNT162b2 and whole-virus inactivated CoronaVac in patients with neuromuscular diseases, particularly those on immunosuppressive drugs and variants of concern, has not been well-established. Our goal was to evaluate medium-term humoral immunogenicity outcomes after 3 doses of these vaccines. Peripheral blood samples were collected from participants 14-49 days and 155-210 days after administration of the third vaccine dose to assess humoral immune responses through serological assays. The immunogenicity outcomes of each patient were compared to those of three age-matched healthy control participants, ensuring a balanced comparison. Both patients that received 3 doses of BNT162b2 and 10 (90.9%) patients that received CoronaVac seroconverted against wild-type-SARS-CoV-2 virus, showing comparable antibody responses to healthy participants. After 6 months, one patient in BNT162b2 and all four patients in CoronaVac groups maintained seropositivity. The JN-1 specific binding antibody response was lower compared to wild-type virus. The use of corticosteroids did not affect seroconversion rate against wild-type virus or JN.1 variant. BNT162b2 and CoronaVac were immunogenic for neuromuscular diseases patients, maintaining durability after 6 months even for those on corticosteroids. Our data support a rapid immunization series utilizing mRNA-based and whole-virus inactivated vaccines for future pandemic.
Keywords: BNT162b2; COVID-19; CoronaVac; immunogenicity; neuromuscular diseases.