tetano
Editor, Senior Moderator
Hum Vaccin Immunother
. 2024 Dec 31;20(1):2344249.
doi: 10.1080/21645515.2024.2344249. Epub 2024 May 6. Driving consistency: CEPI-Centralized Laboratory Network's conversion factor initiative for SARS-CoV-2 clinical assays used for efficacy assessment of COVID vaccines
Ali Azizi[SUP] 1 [/SUP], Gathoni Kamuyu[SUP] 2 [/SUP], Deborah Ogbeni[SUP] 2 [/SUP], Philipa Levesque-Damphousse[SUP] 3 [/SUP], Daniel Knott[SUP] 4 [/SUP], Luc Gagnon[SUP] 3 [/SUP], Steven Phay-Tran[SUP] 3 [/SUP], Bethan Hussey[SUP] 4 [/SUP], Pamela Proud[SUP] 4 [/SUP], Sue Charlton[SUP] 4 [/SUP], Carolyn Clark[SUP] 1 [/SUP], Valentina Bernasconi[SUP] 5 [/SUP]
Affiliations
To date, thousands of SARS-CoV-2 samples from many vaccine developers have been tested within the CEPI-Centralized Laboratory Network. To convert data from each clinical assay to international standard units, the WHO international standard and the CEPI standard generated by the Medicines and Healthcare products Regulatory Agency were run in multiple facilities to determine the conversion factor for each assay. Reporting results in international units advances global understanding of SARS-CoV-2 immunity and vaccine efficacy, enhancing the quality, reliability, and utility of clinical assay data.
Keywords: CEPI-CLN; SARS-CoV-2 pandemic; immunological assays; standardization; vaccine efficacy.
. 2024 Dec 31;20(1):2344249.
doi: 10.1080/21645515.2024.2344249. Epub 2024 May 6. Driving consistency: CEPI-Centralized Laboratory Network's conversion factor initiative for SARS-CoV-2 clinical assays used for efficacy assessment of COVID vaccines
Ali Azizi[SUP] 1 [/SUP], Gathoni Kamuyu[SUP] 2 [/SUP], Deborah Ogbeni[SUP] 2 [/SUP], Philipa Levesque-Damphousse[SUP] 3 [/SUP], Daniel Knott[SUP] 4 [/SUP], Luc Gagnon[SUP] 3 [/SUP], Steven Phay-Tran[SUP] 3 [/SUP], Bethan Hussey[SUP] 4 [/SUP], Pamela Proud[SUP] 4 [/SUP], Sue Charlton[SUP] 4 [/SUP], Carolyn Clark[SUP] 1 [/SUP], Valentina Bernasconi[SUP] 5 [/SUP]
Affiliations
- PMID: 38708549
- DOI: 10.1080/21645515.2024.2344249
To date, thousands of SARS-CoV-2 samples from many vaccine developers have been tested within the CEPI-Centralized Laboratory Network. To convert data from each clinical assay to international standard units, the WHO international standard and the CEPI standard generated by the Medicines and Healthcare products Regulatory Agency were run in multiple facilities to determine the conversion factor for each assay. Reporting results in international units advances global understanding of SARS-CoV-2 immunity and vaccine efficacy, enhancing the quality, reliability, and utility of clinical assay data.
Keywords: CEPI-CLN; SARS-CoV-2 pandemic; immunological assays; standardization; vaccine efficacy.