tetano
Editor, Senior Moderator
Hum Vaccin Immunother
. 2022 Mar 18;1-5.
doi: 10.1080/21645515.2022.2051412. Online ahead of print.
Breakthrough SARS-CoV-2 infections after vaccination: a critical review
Zeinab Mohseni Afshar[SUP] 1 [/SUP], Mohammad Barary[SUP] 2 3 [/SUP], Rezvan Hosseinzadeh[SUP] 4 [/SUP], Amirmasoud Alijanpour[SUP] 5 [/SUP], Dariush Hosseinzadeh[SUP] 6 [/SUP], Soheil Ebrahimpour[SUP] 7 [/SUP], Kosar Nazary[SUP] 4 [/SUP], Terence T Sio[SUP] 8 [/SUP], Mark J M Sullman[SUP] 9 10 [/SUP], Kristin Carson-Chahhoud[SUP] 11 [/SUP], Arefeh Babazadeh[SUP] 7 [/SUP]
Affiliations
Abstract
At the beginning of the current pandemic, it was believed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection would induce lifelong immunity and that reinfections would be unlikely. However, after several cases of reinfection were documented in previously infected patients, this was understood to be a false assumption, and this waning humoral immunity has raised significant concerns. Accordingly, long-term and durable vaccine-induced antibody protection against infection have also become a challenge, as several breakthroughs of COVID-19 infection have been identified in individuals who were fully vaccinated. This review discusses the current evidence on breakthrough COVID-19 infections occurring after vaccination.
Keywords: COVID-19; SARS-CoV-2; breakthrough; immunization; vaccination.
. 2022 Mar 18;1-5.
doi: 10.1080/21645515.2022.2051412. Online ahead of print.
Breakthrough SARS-CoV-2 infections after vaccination: a critical review
Zeinab Mohseni Afshar[SUP] 1 [/SUP], Mohammad Barary[SUP] 2 3 [/SUP], Rezvan Hosseinzadeh[SUP] 4 [/SUP], Amirmasoud Alijanpour[SUP] 5 [/SUP], Dariush Hosseinzadeh[SUP] 6 [/SUP], Soheil Ebrahimpour[SUP] 7 [/SUP], Kosar Nazary[SUP] 4 [/SUP], Terence T Sio[SUP] 8 [/SUP], Mark J M Sullman[SUP] 9 10 [/SUP], Kristin Carson-Chahhoud[SUP] 11 [/SUP], Arefeh Babazadeh[SUP] 7 [/SUP]
Affiliations
- PMID: 35302905
- DOI: 10.1080/21645515.2022.2051412
Abstract
At the beginning of the current pandemic, it was believed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection would induce lifelong immunity and that reinfections would be unlikely. However, after several cases of reinfection were documented in previously infected patients, this was understood to be a false assumption, and this waning humoral immunity has raised significant concerns. Accordingly, long-term and durable vaccine-induced antibody protection against infection have also become a challenge, as several breakthroughs of COVID-19 infection have been identified in individuals who were fully vaccinated. This review discusses the current evidence on breakthrough COVID-19 infections occurring after vaccination.
Keywords: COVID-19; SARS-CoV-2; breakthrough; immunization; vaccination.