tetano
Editor, Senior Moderator
Hum Vaccin Immunother
. 2022 Oct 26;2136435.
doi: 10.1080/21645515.2022.2136435. Online ahead of print.
Adverse reactions to inactivated COVID-19 vaccination in patients with chronic liver disease: The effect of anxiety
Li Lv[SUP] 1 [/SUP], Xiao-Qing Lin[SUP] 2 [/SUP], Yan Chen[SUP] 2 [/SUP], He-Dan Chen[SUP] 1 [/SUP], Mei-Xian Zhang[SUP] 3 [/SUP], Hui Shao[SUP] 2 [/SUP], Tao-Hsin Tung[SUP] 3 [/SUP], Jian-Sheng Zhu[SUP] 1 [/SUP]
Affiliations
Abstract
Studies have shown that patients with chronic liver disease are at a higher risk of contracting novel coronavirus pneumonia than healthy individuals, and many guidelines state that patients with chronic liver disease should be prioritized for COVID-19 vaccination, but there are a few studies on its safety in CLD patients. We aimed to evaluate the safety of the inactivated COVID-19 vaccine in patients with chronic liver disease, and the effect of anxiety on adverse reactions. A questionnaire survey for self-administered post-vaccination adverse reaction monitoring was conducted from June 17, 2021, to August 11, 2021, in patients with chronic liver disease attending a tertiary care hospital in Taizhou, China. We analyzed the data from of a total of 160 participants who scanned the QR code on social media to respond to the questionnaire. The overall incidence of adverse reactions after COVID-19 vaccination in patients with chronic liver disease was 44.4% (71/160), and the most common adverse reaction was local injection site reaction, accounting for 80.3% of adverse reactions (57/71). No serious adverse reactions were reported. Approximately 53.1% of the patients had anxiety about vaccination, and 51.8% of those who felt anxious reported adverse reactions. The safety of COVID-19 vaccination in patients with chronic liver disease is good, and there is a strong association between adverse reactions and vaccine anxiety. Pre-vaccination education for patients with vaccine anxiety and psychological counseling may reduce reports of adverse reactions and improve patients' confidence in the vaccine.
Keywords: Adverse drug reaction; COVID-19; anxiety; liver diseases; vaccines.
. 2022 Oct 26;2136435.
doi: 10.1080/21645515.2022.2136435. Online ahead of print.
Adverse reactions to inactivated COVID-19 vaccination in patients with chronic liver disease: The effect of anxiety
Li Lv[SUP] 1 [/SUP], Xiao-Qing Lin[SUP] 2 [/SUP], Yan Chen[SUP] 2 [/SUP], He-Dan Chen[SUP] 1 [/SUP], Mei-Xian Zhang[SUP] 3 [/SUP], Hui Shao[SUP] 2 [/SUP], Tao-Hsin Tung[SUP] 3 [/SUP], Jian-Sheng Zhu[SUP] 1 [/SUP]
Affiliations
- PMID: 36287551
- DOI: 10.1080/21645515.2022.2136435
Abstract
Studies have shown that patients with chronic liver disease are at a higher risk of contracting novel coronavirus pneumonia than healthy individuals, and many guidelines state that patients with chronic liver disease should be prioritized for COVID-19 vaccination, but there are a few studies on its safety in CLD patients. We aimed to evaluate the safety of the inactivated COVID-19 vaccine in patients with chronic liver disease, and the effect of anxiety on adverse reactions. A questionnaire survey for self-administered post-vaccination adverse reaction monitoring was conducted from June 17, 2021, to August 11, 2021, in patients with chronic liver disease attending a tertiary care hospital in Taizhou, China. We analyzed the data from of a total of 160 participants who scanned the QR code on social media to respond to the questionnaire. The overall incidence of adverse reactions after COVID-19 vaccination in patients with chronic liver disease was 44.4% (71/160), and the most common adverse reaction was local injection site reaction, accounting for 80.3% of adverse reactions (57/71). No serious adverse reactions were reported. Approximately 53.1% of the patients had anxiety about vaccination, and 51.8% of those who felt anxious reported adverse reactions. The safety of COVID-19 vaccination in patients with chronic liver disease is good, and there is a strong association between adverse reactions and vaccine anxiety. Pre-vaccination education for patients with vaccine anxiety and psychological counseling may reduce reports of adverse reactions and improve patients' confidence in the vaccine.
Keywords: Adverse drug reaction; COVID-19; anxiety; liver diseases; vaccines.