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Hum Vaccin Immunother . A retrospective cohort study on the protective effect of influenza vaccination during pregnancy in Gansu Province

tetano

Editor, Senior Moderator
Hum Vaccin Immunother


. 2024 Dec 31;20(1):2418674.
doi: 10.1080/21645515.2024.2418674. Epub 2024 Nov 3. A retrospective cohort study on the protective effect of influenza vaccination during pregnancy in Gansu Province

Xue-Feng Liang[SUP] 1 [/SUP], Juan-Xia Peng[SUP] 1 [/SUP], Di Sun[SUP] 1 [/SUP], Bing-Ling Zhang[SUP] 1 [/SUP], Jing An[SUP] 1 [/SUP], Xiao-Shu Zhang[SUP] 1 [/SUP]



Affiliations
Abstract

To evaluate the Vaccine Effectiveness (VE) of the Influenza Vaccine (InfV) during pregnancy in Gansu province. A retrospective cohort of pregnant women vaccinated with InfV was constructed using the electronic case system and immunization planning system of Gansu province. Outcome information of Influenza-Like Illness (ILI) in pregnant women after vaccination with InfV during the influenza epidemic seasons from 2019 to 2021 was collected. The log-binomial model was used to estimate the adjusted Risk Ratio (RR), VE, and their Confidence Intervals (CI). The incidence rates of the InfV vaccination group and the non-vaccination group during pregnancy in Gansu province were 4.70% (54/1,150) and 6.91% (16,990/245,754), respectively. The adjusted RR was 0.78 (95%CI 0.43-0.75), and the adjusted VE was 22.20 (95%CI 0.79-40.30). Vaccination with InfV during pregnancy in Gansu province from 2019 to 2021 has a protective effect against ILI in pregnant women, and there is no difference in vaccination at different stages of pregnancy.

Keywords: Pregnancy; influenza vaccine; protective effect; vaccination.

 
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