tetano
Editor, Senior Moderator
Hum Mol Genet
. 2022 Jul 15;ddac158.
doi: 10.1093/hmg/ddac158. Online ahead of print.
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
Frauke Degenhardt[SUP] 1 [/SUP], David Ellinghaus[SUP] 1 2 [/SUP], Simonas Juzenas[SUP] 1 3 [/SUP], Jon Lerga-Jaso[SUP] 4 [/SUP], Mareike Wendorff[SUP] 1 [/SUP], Douglas Maya-Miles[SUP] 5 6 7 [/SUP], Florian Uellendahl-Werth[SUP] 1 [/SUP], Hesham ElAbd[SUP] 1 [/SUP], Malte C Rühlemann[SUP] 1 8 [/SUP], Jatin Arora[SUP] 9 10 11 12 13 [/SUP], Onur Özer[SUP] 14 15 [/SUP], Ole Bernt Lenning[SUP] 16 17 [/SUP], Ronny Myhre[SUP] 18 [/SUP], May Sissel Vadla[SUP] 17 19 [/SUP], Eike M Wacker[SUP] 1 [/SUP], Lars Wienbrandt[SUP] 1 [/SUP], Aaron Blandino Ortiz[SUP] 20 [/SUP], Adolfo Salazar[SUP] 21 22 [/SUP], Adolfo Garrido Chercoles[SUP] 23 [/SUP], Adriana Palom[SUP] 24 25 [/SUP], Agustín Ruiz[SUP] 26 27 [/SUP], Alba-Estela Garcia-Fernandez[SUP] 28 [/SUP], Albert Blanco-Grau[SUP] 28 [/SUP], Alberto Mantovani[SUP] 29 30 [/SUP], Alberto Zanella[SUP] 31 32 [/SUP], Aleksander Rygh Holten[SUP] 33 34 [/SUP], Alena Mayer[SUP] 35 [/SUP], Alessandra Bandera[SUP] 31 32 [/SUP], Alessandro Cherubini[SUP] 32 [/SUP], Alessandro Protti[SUP] 29 30 [/SUP], Alessio Aghemo[SUP] 29 30 [/SUP], Alessio Gerussi[SUP] 36 37 [/SUP], Alfredo Ramirez[SUP] 38 39 40 41 42 [/SUP], Alice Braun[SUP] 35 [/SUP], Almut Nebel[SUP] 1 [/SUP], Ana Barreira[SUP] 25 [/SUP], Ana Lleo[SUP] 29 30 [/SUP], Ana Teles[SUP] 14 15 [/SUP], Anders Benjamin Kildal[SUP] 43 [/SUP], Andrea Biondi[SUP] 44 [/SUP], Andrea Caballero-Garralda[SUP] 45 [/SUP], Andrea Ganna[SUP] 46 [/SUP], Andrea Gori[SUP] 32 47 [/SUP], Andreas Glück[SUP] 48 [/SUP], Andreas Lind[SUP] 49 [/SUP], Anja Tanck[SUP] 1 [/SUP], Anke Hinney[SUP] 50 [/SUP], Anna Carreras Nolla[SUP] 51 [/SUP], Anna Ludovica Fracanzani[SUP] 31 32 [/SUP], Anna Peschuck[SUP] 1 [/SUP], Annalisa Cavallero[SUP] 52 [/SUP], Anne Ma Dyrhol-Riise[SUP] 34 53 [/SUP], Antonella Ruello[SUP] 54 [/SUP], Antonio Julià[SUP] 24 [/SUP], Antonio Muscatello[SUP] 32 [/SUP], Antonio Pesenti[SUP] 31 32 [/SUP], Antonio Voza[SUP] 29 30 [/SUP], Ariadna Rando-Segura[SUP] 55 56 [/SUP], Aurora Solier[SUP] 57 [/SUP], Axel Schmidt[SUP] 58 [/SUP], Beatriz Cortes[SUP] 51 [/SUP], Beatriz Mateos[SUP] 6 59 [/SUP], Beatriz Nafria-Jimenez[SUP] 23 [/SUP], Benedikt Schaefer[SUP] 60 61 [/SUP], Björn Jensen[SUP] 62 [/SUP], Carla Bellinghausen[SUP] 63 [/SUP], Carlo Maj[SUP] 64 [/SUP], Carlos Ferrando[SUP] 65 66 [/SUP], Carmen Horra[SUP] 5 7 67 68 69 [/SUP], Carmen Quereda[SUP] 70 [/SUP], Carsten Skurk[SUP] 35 [/SUP], Charlotte Thibeault[SUP] 35 [/SUP], Chiara Scollo[SUP] 71 [/SUP], Christian Herr[SUP] 72 [/SUP], Christoph D Spinner[SUP] 73 [/SUP], Christoph Gassner[SUP] 1 74 [/SUP], Christoph Lange[SUP] 75 76 77 [/SUP], Cinzia Hu[SUP] 78 [/SUP], Cinzia Paccapelo[SUP] 32 [/SUP], Clara Lehmann[SUP] 79 80 81 [/SUP], Claudio Angelini[SUP] 82 [/SUP], Claudio Cappadona[SUP] 30 [/SUP], Clinton Azuure[SUP] 14 15 [/SUP], COVICAT study group, Aachen Study (COVAS); Cristiana Bianco[SUP] 32 [/SUP], Cristina Cea[SUP] 28 [/SUP], Cristina Sancho[SUP] 83 [/SUP], Dag Arne Lihaug Hoff[SUP] 84 85 [/SUP], Daniela Galimberti[SUP] 31 32 [/SUP], Daniele Prati[SUP] 32 [/SUP], David Haschka[SUP] 86 [/SUP], David Jiménez[SUP] 57 [/SUP], David Pestaña[SUP] 87 [/SUP], David Toapanta[SUP] 66 [/SUP], Eduardo Muñiz-Diaz[SUP] 88 [/SUP], Elena Azzolini[SUP] 29 30 [/SUP], Elena Sandoval[SUP] 66 [/SUP], Eleonora Binatti[SUP] 36 37 [/SUP], Elio Scarpini[SUP] 31 32 [/SUP], Elisa T Helbig[SUP] 35 [/SUP], Elisabetta Casalone[SUP] 89 [/SUP], Eloisa Urrechaga[SUP] 90 91 [/SUP], Elvezia Maria Paraboschi[SUP] 29 30 [/SUP], Emanuele Pontali[SUP] 92 [/SUP], Enric Reverter[SUP] 66 [/SUP], Enrique J Calderón[SUP] 5 7 67 68 69 [/SUP], Enrique Navas[SUP] 70 [/SUP], Erik Solligård[SUP] 93 94 [/SUP], Ernesto Contro[SUP] 95 [/SUP], Eunate Arana-Arri[SUP] 96 [/SUP], Fátima Aziz[SUP] 66 [/SUP], Federico Garcia[SUP] 21 22 97 [/SUP], Félix García Sánchez[SUP] 98 [/SUP], Ferruccio Ceriotti[SUP] 32 [/SUP], Filippo Martinelli-Boneschi[SUP] 99 100 [/SUP], Flora Peyvandi[SUP] 101 102 [/SUP], Florian Kurth[SUP] 35 103 [/SUP], Francesco Blasi[SUP] 104 105 [/SUP], Francesco Malvestiti[SUP] 31 [/SUP], Francisco J Medrano[SUP] 7 67 68 69 106 [/SUP], Francisco Mesonero[SUP] 6 59 [/SUP], Francisco Rodriguez-Frias[SUP] 6 24 56 107 [/SUP], Frank Hanses[SUP] 108 109 [/SUP], Fredrik Müller[SUP] 34 49 [/SUP], Georg Hemmrich-Stanisak[SUP] 1 [/SUP], Giacomo Bellani[SUP] 110 111 [/SUP], Giacomo Grasselli[SUP] 31 32 [/SUP], Gianni Pezzoli[SUP] 112 [/SUP], Giorgio Costantino[SUP] 31 32 [/SUP], Giovanni Albano[SUP] 54 [/SUP], Giulia Cardamone[SUP] 30 [/SUP], Giuseppe Bellelli[SUP] 111 113 [/SUP], Giuseppe Citerio[SUP] 111 114 [/SUP], Giuseppe Foti[SUP] 110 111 [/SUP], Giuseppe Lamorte[SUP] 32 [/SUP], Giuseppe Matullo[SUP] 89 [/SUP], Guido Baselli[SUP] 32 [/SUP], Hayato Kurihara[SUP] 82 [/SUP], Holger Neb[SUP] 115 [/SUP], Ilaria My[SUP] 29 [/SUP], Ingo Kurth[SUP] 116 [/SUP], Isabel Hernández[SUP] 26 27 [/SUP], Isabell Pink[SUP] 117 [/SUP], Itziar Rojas[SUP] 26 27 [/SUP], Iván Galván-Femenia[SUP] 51 [/SUP], Jan Cato Holter[SUP] 34 49 [/SUP], Jan Egil Afset[SUP] 84 118 [/SUP], Jan Heyckendorf[SUP] 75 76 77 [/SUP], Jan Kässens[SUP] 1 [/SUP], Jan Kristian Damås[SUP] 119 120 [/SUP], Jan Rybniker[SUP] 79 80 121 [/SUP], Janine Altmüller[SUP] 122 [/SUP], Javier Ampuero[SUP] 5 6 7 67 123 [/SUP], Javier Martín[SUP] 124 [/SUP], Jeanette Erdmann[SUP] 125 126 127 [/SUP], Jesus M Banales[SUP] 6 128 129 [/SUP], Joan Ramon Badia[SUP] 130 [/SUP], Joaquin Dopazo[SUP] 7 131 [/SUP], Jochen Schneider[SUP] 73 [/SUP], Jonas Bergan[SUP] 132 [/SUP], Jordi Barretina[SUP] 133 [/SUP], Jörn Walter[SUP] 134 [/SUP], Jose Hernández Quero[SUP] 21 135 [/SUP], Josune Goikoetxea[SUP] 136 [/SUP], Juan Delgado[SUP] 5 7 67 68 69 [/SUP], Juan M Guerrero[SUP] 5 7 67 [/SUP], Julia Fazaal[SUP] 58 [/SUP], Julia Kraft[SUP] 35 [/SUP], Julia Schröder[SUP] 58 [/SUP], Kari Risnes[SUP] 120 137 [/SUP], Karina Banasik[SUP] 2 [/SUP], Karl Erik Müller[SUP] 138 [/SUP], Karoline I Gaede[SUP] 139 140 141 [/SUP], Koldo Garcia-Etxebarria[SUP] 6 128 [/SUP], Kristian Tonby[SUP] 34 53 [/SUP], Lars Heggelund[SUP] 138 142 [/SUP], Laura Izquierdo-Sanchez[SUP] 6 128 143 [/SUP], Laura Rachele Bettini[SUP] 44 [/SUP], Lauro Sumoy[SUP] 133 [/SUP], Leif Erik Sander[SUP] 35 [/SUP], Lena J Lippert[SUP] 35 [/SUP], Leonardo Terranova[SUP] 32 [/SUP], Lindokuhle Nkambule[SUP] 144 145 [/SUP], Lisa Knopp[SUP] 62 [/SUP], Lise Tuset Gustad[SUP] 93 146 [/SUP], Lucia Garbarino[SUP] 147 [/SUP], Luigi Santoro[SUP] 32 [/SUP], Luis Téllez[SUP] 6 59 [/SUP], Luisa Roade[SUP] 6 25 56 [/SUP], Mahnoosh Ostadreza[SUP] 32 [/SUP], Maider Intxausti[SUP] 83 [/SUP], Manolis Kogevinas[SUP] 68 148 149 150 [/SUP], Mar Riveiro-Barciela[SUP] 6 25 56 [/SUP], Marc M Berger[SUP] 151 [/SUP], Marco Schaefer[SUP] 152 [/SUP], Mari E K Niemi[SUP] 46 [/SUP], María A Gutiérrez-Stampa[SUP] 153 [/SUP], Maria Carrabba[SUP] 78 [/SUP], Maria E Figuera Basso[SUP] 1 [/SUP], Maria Grazia Valsecchi[SUP] 154 [/SUP], María Hernandez-Tejero[SUP] 66 [/SUP], Maria J G T Vehreschild[SUP] 155 [/SUP], Maria Manunta[SUP] 32 [/SUP], Marialbert Acosta-Herrera[SUP] 124 [/SUP], Mariella D'Angiò[SUP] 44 [/SUP], Marina Baldini[SUP] 32 [/SUP], Marina Cazzaniga[SUP] 156 [/SUP], Marit M Grimsrud[SUP] 34 157 158 [/SUP], Markus Cornberg[SUP] 159 [/SUP], Markus M Nöthen[SUP] 58 [/SUP], Marta Marquié[SUP] 26 27 [/SUP], Massimo Castoldi[SUP] 54 [/SUP], Mattia Cordioli[SUP] 46 [/SUP], Maurizio Cecconi[SUP] 29 30 [/SUP], Mauro D'Amato[SUP] 129 160 161 [/SUP], Max Augustin[SUP] 79 80 81 [/SUP], Melissa Tomasi[SUP] 32 [/SUP], Mercè Boada[SUP] 26 27 [/SUP], Michael Dreher[SUP] 162 [/SUP], Michael J Seilmaier[SUP] 163 [/SUP], Michael Joannidis[SUP] 164 [/SUP], Michael Wittig[SUP] 1 [/SUP], Michela Mazzocco[SUP] 147 [/SUP], Michele Ciccarelli[SUP] 82 [/SUP], Miguel Rodríguez-Gandía[SUP] 6 59 [/SUP], Monica Bocciolone[SUP] 82 [/SUP], Monica Miozzo[SUP] 31 78 [/SUP], Natale Imaz Ayo[SUP] 96 [/SUP], Natalia Blay[SUP] 51 [/SUP], Natalia Chueca[SUP] 22 [/SUP], Nicola Montano[SUP] 31 32 [/SUP], Nicole Braun[SUP] 1 165 [/SUP], Nicole Ludwig[SUP] 166 [/SUP], Nikolaus Marx[SUP] 167 [/SUP], Nilda Martínez[SUP] 168 [/SUP], Norwegian SARS-CoV-2 Study group; Oliver A Cornely[SUP] 40 79 81 169 [/SUP], Oliver Witzke[SUP] 170 [/SUP], Orazio Palmieri[SUP] 171 [/SUP], Pa Study Group; Paola Faverio[SUP] 111 172 [/SUP], Paoletta Preatoni[SUP] 82 [/SUP], Paolo Bonfanti[SUP] 111 173 [/SUP], Paolo Omodei[SUP] 82 [/SUP], Paolo Tentorio[SUP] 29 [/SUP], Pedro Castro[SUP] 66 [/SUP], Pedro M Rodrigues[SUP] 6 128 129 143 [/SUP], Pedro Pablo España[SUP] 90 [/SUP], Per Hoffmann[SUP] 58 [/SUP], Philip Rosenstiel[SUP] 1 [/SUP], Philipp Schommers[SUP] 79 80 81 [/SUP], Phillip Suwalski[SUP] 35 [/SUP], Raúl Pablo[SUP] 20 [/SUP], Ricard Ferrer[SUP] 174 [/SUP], Robert Bals[SUP] 72 [/SUP], Roberta Gualtierotti[SUP] 31 32 [/SUP], Rocío Gallego-Durán[SUP] 5 6 7 [/SUP], Rosa Nieto[SUP] 57 [/SUP], Rossana Carpani[SUP] 32 [/SUP], Rubén Morilla[SUP] 5 7 67 68 69 [/SUP], Salvatore Badalamenti[SUP] 29 [/SUP], Sammra Haider[SUP] 175 [/SUP], Sandra Ciesek[SUP] 176 177 [/SUP], Sandra May[SUP] 1 [/SUP], Sara Bombace[SUP] 29 30 [/SUP], Sara Marsal[SUP] 24 [/SUP], Sara Pigazzini[SUP] 46 [/SUP], Sebastian Klein[SUP] 164 [/SUP], Serena Pelusi[SUP] 31 32 [/SUP], Sibylle Wilfling[SUP] 109 178 179 [/SUP], Silvano Bosari[SUP] 31 32 [/SUP], Sonja Volland[SUP] 180 [/SUP], Søren Brunak[SUP] 2 [/SUP], Soumya Raychaudhuri[SUP] 9 10 11 12 13 181 [/SUP], Stefan Schreiber[SUP] 1 48 [/SUP], Stefanie Heilmann-Heimbach[SUP] 58 [/SUP], Stefano Aliberti[SUP] 29 30 [/SUP], Stephan Ripke[SUP] 35 [/SUP], Susanne Dudman[SUP] 34 49 [/SUP], Tanja Wesse[SUP] 1 [/SUP], Tenghao Zheng[SUP] 182 [/SUP], STORM Study group, The Humanitas Task Force, The Humanitas Gavazzeni Task Force; Thomas Bahmer[SUP] 48 [/SUP], Thomas Eggermann[SUP] 116 [/SUP], Thomas Illig[SUP] 180 [/SUP], Thorsten Brenner[SUP] 151 [/SUP], Tomas Pumarola[SUP] 183 184 [/SUP], Torsten Feldt[SUP] 62 [/SUP], Trine Folseraas[SUP] 34 157 158 185 [/SUP], Trinidad Gonzalez Cejudo[SUP] 186 [/SUP], Ulf Landmesser[SUP] 187 [/SUP], Ulrike Protzer[SUP] 188 189 [/SUP], Ute Hehr[SUP] 178 [/SUP], Valeria Rimoldi[SUP] 30 [/SUP], Valter Monzani[SUP] 32 [/SUP], Vegard Skogen[SUP] 190 191 [/SUP], Verena Keitel[SUP] 62 [/SUP], Verena Kopfnagel[SUP] 180 [/SUP], Vicente Friaza[SUP] 5 7 67 68 69 [/SUP], Victor Andrade[SUP] 38 39 [/SUP], Victor Moreno[SUP] 68 192 193 194 [/SUP], Wolfgang Albrecht[SUP] 1 [/SUP], Wolfgang Peter[SUP] 152 195 [/SUP], Wolfgang Poller[SUP] 35 [/SUP], Xavier Farre[SUP] 51 [/SUP], Xiaoli Yi[SUP] 1 [/SUP], Xiaomin Wang[SUP] 35 [/SUP], Yascha Khodamoradi[SUP] 155 [/SUP], Zehra Karadeniz[SUP] 35 [/SUP], Anna Latiano[SUP] 171 [/SUP], Siegfried Goerg[SUP] 196 [/SUP], Petra Bacher[SUP] 1 197 [/SUP], Philipp Koehler[SUP] 40 79 80 [/SUP], Florian Tran[SUP] 1 48 [/SUP], Heinz Zoller[SUP] 60 61 [/SUP], Eva C Schulte[SUP] 188 198 199 [/SUP], Bettina Heidecker[SUP] 35 [/SUP], Kerstin U Ludwig[SUP] 58 [/SUP], Javier Fernández[SUP] 66 200 [/SUP], Manuel Romero-Gómez[SUP] 5 6 7 67 123 [/SUP], Agustín Albillos[SUP] 6 59 [/SUP], Pietro Invernizzi[SUP] 36 37 [/SUP], Maria Buti[SUP] 6 25 56 [/SUP], Stefano Duga[SUP] 29 30 [/SUP], Luis Bujanda[SUP] 6 128 [/SUP], Johannes R Hov[SUP] 34 157 158 185 [/SUP], Tobias L Lenz[SUP] 14 15 [/SUP], Rosanna Asselta[SUP] 29 30 [/SUP], Rafael Cid[SUP] 51 [/SUP], Luca Valenti[SUP] 31 32 [/SUP], Tom H Karlsen[SUP] 34 157 158 185 [/SUP], Mario Cáceres[SUP] 4 201 [/SUP], Andre Franke[SUP] 1 202 [/SUP]
Affiliations
Abstract
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~ 0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.
. 2022 Jul 15;ddac158.
doi: 10.1093/hmg/ddac158. Online ahead of print.
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
Frauke Degenhardt[SUP] 1 [/SUP], David Ellinghaus[SUP] 1 2 [/SUP], Simonas Juzenas[SUP] 1 3 [/SUP], Jon Lerga-Jaso[SUP] 4 [/SUP], Mareike Wendorff[SUP] 1 [/SUP], Douglas Maya-Miles[SUP] 5 6 7 [/SUP], Florian Uellendahl-Werth[SUP] 1 [/SUP], Hesham ElAbd[SUP] 1 [/SUP], Malte C Rühlemann[SUP] 1 8 [/SUP], Jatin Arora[SUP] 9 10 11 12 13 [/SUP], Onur Özer[SUP] 14 15 [/SUP], Ole Bernt Lenning[SUP] 16 17 [/SUP], Ronny Myhre[SUP] 18 [/SUP], May Sissel Vadla[SUP] 17 19 [/SUP], Eike M Wacker[SUP] 1 [/SUP], Lars Wienbrandt[SUP] 1 [/SUP], Aaron Blandino Ortiz[SUP] 20 [/SUP], Adolfo Salazar[SUP] 21 22 [/SUP], Adolfo Garrido Chercoles[SUP] 23 [/SUP], Adriana Palom[SUP] 24 25 [/SUP], Agustín Ruiz[SUP] 26 27 [/SUP], Alba-Estela Garcia-Fernandez[SUP] 28 [/SUP], Albert Blanco-Grau[SUP] 28 [/SUP], Alberto Mantovani[SUP] 29 30 [/SUP], Alberto Zanella[SUP] 31 32 [/SUP], Aleksander Rygh Holten[SUP] 33 34 [/SUP], Alena Mayer[SUP] 35 [/SUP], Alessandra Bandera[SUP] 31 32 [/SUP], Alessandro Cherubini[SUP] 32 [/SUP], Alessandro Protti[SUP] 29 30 [/SUP], Alessio Aghemo[SUP] 29 30 [/SUP], Alessio Gerussi[SUP] 36 37 [/SUP], Alfredo Ramirez[SUP] 38 39 40 41 42 [/SUP], Alice Braun[SUP] 35 [/SUP], Almut Nebel[SUP] 1 [/SUP], Ana Barreira[SUP] 25 [/SUP], Ana Lleo[SUP] 29 30 [/SUP], Ana Teles[SUP] 14 15 [/SUP], Anders Benjamin Kildal[SUP] 43 [/SUP], Andrea Biondi[SUP] 44 [/SUP], Andrea Caballero-Garralda[SUP] 45 [/SUP], Andrea Ganna[SUP] 46 [/SUP], Andrea Gori[SUP] 32 47 [/SUP], Andreas Glück[SUP] 48 [/SUP], Andreas Lind[SUP] 49 [/SUP], Anja Tanck[SUP] 1 [/SUP], Anke Hinney[SUP] 50 [/SUP], Anna Carreras Nolla[SUP] 51 [/SUP], Anna Ludovica Fracanzani[SUP] 31 32 [/SUP], Anna Peschuck[SUP] 1 [/SUP], Annalisa Cavallero[SUP] 52 [/SUP], Anne Ma Dyrhol-Riise[SUP] 34 53 [/SUP], Antonella Ruello[SUP] 54 [/SUP], Antonio Julià[SUP] 24 [/SUP], Antonio Muscatello[SUP] 32 [/SUP], Antonio Pesenti[SUP] 31 32 [/SUP], Antonio Voza[SUP] 29 30 [/SUP], Ariadna Rando-Segura[SUP] 55 56 [/SUP], Aurora Solier[SUP] 57 [/SUP], Axel Schmidt[SUP] 58 [/SUP], Beatriz Cortes[SUP] 51 [/SUP], Beatriz Mateos[SUP] 6 59 [/SUP], Beatriz Nafria-Jimenez[SUP] 23 [/SUP], Benedikt Schaefer[SUP] 60 61 [/SUP], Björn Jensen[SUP] 62 [/SUP], Carla Bellinghausen[SUP] 63 [/SUP], Carlo Maj[SUP] 64 [/SUP], Carlos Ferrando[SUP] 65 66 [/SUP], Carmen Horra[SUP] 5 7 67 68 69 [/SUP], Carmen Quereda[SUP] 70 [/SUP], Carsten Skurk[SUP] 35 [/SUP], Charlotte Thibeault[SUP] 35 [/SUP], Chiara Scollo[SUP] 71 [/SUP], Christian Herr[SUP] 72 [/SUP], Christoph D Spinner[SUP] 73 [/SUP], Christoph Gassner[SUP] 1 74 [/SUP], Christoph Lange[SUP] 75 76 77 [/SUP], Cinzia Hu[SUP] 78 [/SUP], Cinzia Paccapelo[SUP] 32 [/SUP], Clara Lehmann[SUP] 79 80 81 [/SUP], Claudio Angelini[SUP] 82 [/SUP], Claudio Cappadona[SUP] 30 [/SUP], Clinton Azuure[SUP] 14 15 [/SUP], COVICAT study group, Aachen Study (COVAS); Cristiana Bianco[SUP] 32 [/SUP], Cristina Cea[SUP] 28 [/SUP], Cristina Sancho[SUP] 83 [/SUP], Dag Arne Lihaug Hoff[SUP] 84 85 [/SUP], Daniela Galimberti[SUP] 31 32 [/SUP], Daniele Prati[SUP] 32 [/SUP], David Haschka[SUP] 86 [/SUP], David Jiménez[SUP] 57 [/SUP], David Pestaña[SUP] 87 [/SUP], David Toapanta[SUP] 66 [/SUP], Eduardo Muñiz-Diaz[SUP] 88 [/SUP], Elena Azzolini[SUP] 29 30 [/SUP], Elena Sandoval[SUP] 66 [/SUP], Eleonora Binatti[SUP] 36 37 [/SUP], Elio Scarpini[SUP] 31 32 [/SUP], Elisa T Helbig[SUP] 35 [/SUP], Elisabetta Casalone[SUP] 89 [/SUP], Eloisa Urrechaga[SUP] 90 91 [/SUP], Elvezia Maria Paraboschi[SUP] 29 30 [/SUP], Emanuele Pontali[SUP] 92 [/SUP], Enric Reverter[SUP] 66 [/SUP], Enrique J Calderón[SUP] 5 7 67 68 69 [/SUP], Enrique Navas[SUP] 70 [/SUP], Erik Solligård[SUP] 93 94 [/SUP], Ernesto Contro[SUP] 95 [/SUP], Eunate Arana-Arri[SUP] 96 [/SUP], Fátima Aziz[SUP] 66 [/SUP], Federico Garcia[SUP] 21 22 97 [/SUP], Félix García Sánchez[SUP] 98 [/SUP], Ferruccio Ceriotti[SUP] 32 [/SUP], Filippo Martinelli-Boneschi[SUP] 99 100 [/SUP], Flora Peyvandi[SUP] 101 102 [/SUP], Florian Kurth[SUP] 35 103 [/SUP], Francesco Blasi[SUP] 104 105 [/SUP], Francesco Malvestiti[SUP] 31 [/SUP], Francisco J Medrano[SUP] 7 67 68 69 106 [/SUP], Francisco Mesonero[SUP] 6 59 [/SUP], Francisco Rodriguez-Frias[SUP] 6 24 56 107 [/SUP], Frank Hanses[SUP] 108 109 [/SUP], Fredrik Müller[SUP] 34 49 [/SUP], Georg Hemmrich-Stanisak[SUP] 1 [/SUP], Giacomo Bellani[SUP] 110 111 [/SUP], Giacomo Grasselli[SUP] 31 32 [/SUP], Gianni Pezzoli[SUP] 112 [/SUP], Giorgio Costantino[SUP] 31 32 [/SUP], Giovanni Albano[SUP] 54 [/SUP], Giulia Cardamone[SUP] 30 [/SUP], Giuseppe Bellelli[SUP] 111 113 [/SUP], Giuseppe Citerio[SUP] 111 114 [/SUP], Giuseppe Foti[SUP] 110 111 [/SUP], Giuseppe Lamorte[SUP] 32 [/SUP], Giuseppe Matullo[SUP] 89 [/SUP], Guido Baselli[SUP] 32 [/SUP], Hayato Kurihara[SUP] 82 [/SUP], Holger Neb[SUP] 115 [/SUP], Ilaria My[SUP] 29 [/SUP], Ingo Kurth[SUP] 116 [/SUP], Isabel Hernández[SUP] 26 27 [/SUP], Isabell Pink[SUP] 117 [/SUP], Itziar Rojas[SUP] 26 27 [/SUP], Iván Galván-Femenia[SUP] 51 [/SUP], Jan Cato Holter[SUP] 34 49 [/SUP], Jan Egil Afset[SUP] 84 118 [/SUP], Jan Heyckendorf[SUP] 75 76 77 [/SUP], Jan Kässens[SUP] 1 [/SUP], Jan Kristian Damås[SUP] 119 120 [/SUP], Jan Rybniker[SUP] 79 80 121 [/SUP], Janine Altmüller[SUP] 122 [/SUP], Javier Ampuero[SUP] 5 6 7 67 123 [/SUP], Javier Martín[SUP] 124 [/SUP], Jeanette Erdmann[SUP] 125 126 127 [/SUP], Jesus M Banales[SUP] 6 128 129 [/SUP], Joan Ramon Badia[SUP] 130 [/SUP], Joaquin Dopazo[SUP] 7 131 [/SUP], Jochen Schneider[SUP] 73 [/SUP], Jonas Bergan[SUP] 132 [/SUP], Jordi Barretina[SUP] 133 [/SUP], Jörn Walter[SUP] 134 [/SUP], Jose Hernández Quero[SUP] 21 135 [/SUP], Josune Goikoetxea[SUP] 136 [/SUP], Juan Delgado[SUP] 5 7 67 68 69 [/SUP], Juan M Guerrero[SUP] 5 7 67 [/SUP], Julia Fazaal[SUP] 58 [/SUP], Julia Kraft[SUP] 35 [/SUP], Julia Schröder[SUP] 58 [/SUP], Kari Risnes[SUP] 120 137 [/SUP], Karina Banasik[SUP] 2 [/SUP], Karl Erik Müller[SUP] 138 [/SUP], Karoline I Gaede[SUP] 139 140 141 [/SUP], Koldo Garcia-Etxebarria[SUP] 6 128 [/SUP], Kristian Tonby[SUP] 34 53 [/SUP], Lars Heggelund[SUP] 138 142 [/SUP], Laura Izquierdo-Sanchez[SUP] 6 128 143 [/SUP], Laura Rachele Bettini[SUP] 44 [/SUP], Lauro Sumoy[SUP] 133 [/SUP], Leif Erik Sander[SUP] 35 [/SUP], Lena J Lippert[SUP] 35 [/SUP], Leonardo Terranova[SUP] 32 [/SUP], Lindokuhle Nkambule[SUP] 144 145 [/SUP], Lisa Knopp[SUP] 62 [/SUP], Lise Tuset Gustad[SUP] 93 146 [/SUP], Lucia Garbarino[SUP] 147 [/SUP], Luigi Santoro[SUP] 32 [/SUP], Luis Téllez[SUP] 6 59 [/SUP], Luisa Roade[SUP] 6 25 56 [/SUP], Mahnoosh Ostadreza[SUP] 32 [/SUP], Maider Intxausti[SUP] 83 [/SUP], Manolis Kogevinas[SUP] 68 148 149 150 [/SUP], Mar Riveiro-Barciela[SUP] 6 25 56 [/SUP], Marc M Berger[SUP] 151 [/SUP], Marco Schaefer[SUP] 152 [/SUP], Mari E K Niemi[SUP] 46 [/SUP], María A Gutiérrez-Stampa[SUP] 153 [/SUP], Maria Carrabba[SUP] 78 [/SUP], Maria E Figuera Basso[SUP] 1 [/SUP], Maria Grazia Valsecchi[SUP] 154 [/SUP], María Hernandez-Tejero[SUP] 66 [/SUP], Maria J G T Vehreschild[SUP] 155 [/SUP], Maria Manunta[SUP] 32 [/SUP], Marialbert Acosta-Herrera[SUP] 124 [/SUP], Mariella D'Angiò[SUP] 44 [/SUP], Marina Baldini[SUP] 32 [/SUP], Marina Cazzaniga[SUP] 156 [/SUP], Marit M Grimsrud[SUP] 34 157 158 [/SUP], Markus Cornberg[SUP] 159 [/SUP], Markus M Nöthen[SUP] 58 [/SUP], Marta Marquié[SUP] 26 27 [/SUP], Massimo Castoldi[SUP] 54 [/SUP], Mattia Cordioli[SUP] 46 [/SUP], Maurizio Cecconi[SUP] 29 30 [/SUP], Mauro D'Amato[SUP] 129 160 161 [/SUP], Max Augustin[SUP] 79 80 81 [/SUP], Melissa Tomasi[SUP] 32 [/SUP], Mercè Boada[SUP] 26 27 [/SUP], Michael Dreher[SUP] 162 [/SUP], Michael J Seilmaier[SUP] 163 [/SUP], Michael Joannidis[SUP] 164 [/SUP], Michael Wittig[SUP] 1 [/SUP], Michela Mazzocco[SUP] 147 [/SUP], Michele Ciccarelli[SUP] 82 [/SUP], Miguel Rodríguez-Gandía[SUP] 6 59 [/SUP], Monica Bocciolone[SUP] 82 [/SUP], Monica Miozzo[SUP] 31 78 [/SUP], Natale Imaz Ayo[SUP] 96 [/SUP], Natalia Blay[SUP] 51 [/SUP], Natalia Chueca[SUP] 22 [/SUP], Nicola Montano[SUP] 31 32 [/SUP], Nicole Braun[SUP] 1 165 [/SUP], Nicole Ludwig[SUP] 166 [/SUP], Nikolaus Marx[SUP] 167 [/SUP], Nilda Martínez[SUP] 168 [/SUP], Norwegian SARS-CoV-2 Study group; Oliver A Cornely[SUP] 40 79 81 169 [/SUP], Oliver Witzke[SUP] 170 [/SUP], Orazio Palmieri[SUP] 171 [/SUP], Pa Study Group; Paola Faverio[SUP] 111 172 [/SUP], Paoletta Preatoni[SUP] 82 [/SUP], Paolo Bonfanti[SUP] 111 173 [/SUP], Paolo Omodei[SUP] 82 [/SUP], Paolo Tentorio[SUP] 29 [/SUP], Pedro Castro[SUP] 66 [/SUP], Pedro M Rodrigues[SUP] 6 128 129 143 [/SUP], Pedro Pablo España[SUP] 90 [/SUP], Per Hoffmann[SUP] 58 [/SUP], Philip Rosenstiel[SUP] 1 [/SUP], Philipp Schommers[SUP] 79 80 81 [/SUP], Phillip Suwalski[SUP] 35 [/SUP], Raúl Pablo[SUP] 20 [/SUP], Ricard Ferrer[SUP] 174 [/SUP], Robert Bals[SUP] 72 [/SUP], Roberta Gualtierotti[SUP] 31 32 [/SUP], Rocío Gallego-Durán[SUP] 5 6 7 [/SUP], Rosa Nieto[SUP] 57 [/SUP], Rossana Carpani[SUP] 32 [/SUP], Rubén Morilla[SUP] 5 7 67 68 69 [/SUP], Salvatore Badalamenti[SUP] 29 [/SUP], Sammra Haider[SUP] 175 [/SUP], Sandra Ciesek[SUP] 176 177 [/SUP], Sandra May[SUP] 1 [/SUP], Sara Bombace[SUP] 29 30 [/SUP], Sara Marsal[SUP] 24 [/SUP], Sara Pigazzini[SUP] 46 [/SUP], Sebastian Klein[SUP] 164 [/SUP], Serena Pelusi[SUP] 31 32 [/SUP], Sibylle Wilfling[SUP] 109 178 179 [/SUP], Silvano Bosari[SUP] 31 32 [/SUP], Sonja Volland[SUP] 180 [/SUP], Søren Brunak[SUP] 2 [/SUP], Soumya Raychaudhuri[SUP] 9 10 11 12 13 181 [/SUP], Stefan Schreiber[SUP] 1 48 [/SUP], Stefanie Heilmann-Heimbach[SUP] 58 [/SUP], Stefano Aliberti[SUP] 29 30 [/SUP], Stephan Ripke[SUP] 35 [/SUP], Susanne Dudman[SUP] 34 49 [/SUP], Tanja Wesse[SUP] 1 [/SUP], Tenghao Zheng[SUP] 182 [/SUP], STORM Study group, The Humanitas Task Force, The Humanitas Gavazzeni Task Force; Thomas Bahmer[SUP] 48 [/SUP], Thomas Eggermann[SUP] 116 [/SUP], Thomas Illig[SUP] 180 [/SUP], Thorsten Brenner[SUP] 151 [/SUP], Tomas Pumarola[SUP] 183 184 [/SUP], Torsten Feldt[SUP] 62 [/SUP], Trine Folseraas[SUP] 34 157 158 185 [/SUP], Trinidad Gonzalez Cejudo[SUP] 186 [/SUP], Ulf Landmesser[SUP] 187 [/SUP], Ulrike Protzer[SUP] 188 189 [/SUP], Ute Hehr[SUP] 178 [/SUP], Valeria Rimoldi[SUP] 30 [/SUP], Valter Monzani[SUP] 32 [/SUP], Vegard Skogen[SUP] 190 191 [/SUP], Verena Keitel[SUP] 62 [/SUP], Verena Kopfnagel[SUP] 180 [/SUP], Vicente Friaza[SUP] 5 7 67 68 69 [/SUP], Victor Andrade[SUP] 38 39 [/SUP], Victor Moreno[SUP] 68 192 193 194 [/SUP], Wolfgang Albrecht[SUP] 1 [/SUP], Wolfgang Peter[SUP] 152 195 [/SUP], Wolfgang Poller[SUP] 35 [/SUP], Xavier Farre[SUP] 51 [/SUP], Xiaoli Yi[SUP] 1 [/SUP], Xiaomin Wang[SUP] 35 [/SUP], Yascha Khodamoradi[SUP] 155 [/SUP], Zehra Karadeniz[SUP] 35 [/SUP], Anna Latiano[SUP] 171 [/SUP], Siegfried Goerg[SUP] 196 [/SUP], Petra Bacher[SUP] 1 197 [/SUP], Philipp Koehler[SUP] 40 79 80 [/SUP], Florian Tran[SUP] 1 48 [/SUP], Heinz Zoller[SUP] 60 61 [/SUP], Eva C Schulte[SUP] 188 198 199 [/SUP], Bettina Heidecker[SUP] 35 [/SUP], Kerstin U Ludwig[SUP] 58 [/SUP], Javier Fernández[SUP] 66 200 [/SUP], Manuel Romero-Gómez[SUP] 5 6 7 67 123 [/SUP], Agustín Albillos[SUP] 6 59 [/SUP], Pietro Invernizzi[SUP] 36 37 [/SUP], Maria Buti[SUP] 6 25 56 [/SUP], Stefano Duga[SUP] 29 30 [/SUP], Luis Bujanda[SUP] 6 128 [/SUP], Johannes R Hov[SUP] 34 157 158 185 [/SUP], Tobias L Lenz[SUP] 14 15 [/SUP], Rosanna Asselta[SUP] 29 30 [/SUP], Rafael Cid[SUP] 51 [/SUP], Luca Valenti[SUP] 31 32 [/SUP], Tom H Karlsen[SUP] 34 157 158 185 [/SUP], Mario Cáceres[SUP] 4 201 [/SUP], Andre Franke[SUP] 1 202 [/SUP]
Affiliations
- PMID: 35848942
- DOI: 10.1093/hmg/ddac158
Abstract
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~ 0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.