tetano
Editor, Senior Moderator
Hum Fertil (Camb)
. 2023 Mar 15;1-9.
doi: 10.1080/14647273.2023.2181710. Online ahead of print.
The effect of COVID-19 vaccinations on menstrual cycle and serum anti-Mullerian hormone levels in reproductive age women
Pinar Solmaz Hasdemir[SUP] 1 [/SUP], Sebnem Senol Akar[SUP] 2 [/SUP], Asli Goker[SUP] 1 [/SUP], Funda Kosova[SUP] 3 [/SUP], Duygu Ucar[SUP] 1 [/SUP], Funda Seher Ozalp Ates[SUP] 4 [/SUP], Sinem Akcali[SUP] 5 [/SUP]
Affiliations
Abstract
The aim of this prospective cohort study was to investigate the effect of coronavirus disease 2019 (COVID-19) vaccinations on menstrual cycle and ovarian reserve in reproductive aged-women. Health care providers (n = 258) vaccinated with inactivated (CoronaVac) and mRNA based (Pfizer-BioNTech®) COVID-19 vaccines were included. All subjects completed a gynaecological and menstrual history questionnaire and Anti-Mullerian Hormone (AMH) levels were measured in serum samples collected before first vaccination and at 1[SUP]st[/SUP], 3[SUP]rd[/SUP], 6[SUP]th[/SUP] and 9[SUP]th[/SUP] months. The prevalence of new-onset menstrual dysregulation following vaccination was 20.6% and it was statistically significant compared to baseline (p = 0.001). Menstrual pattern turned back to normal in 59.6% of vaccinated women. Serum AMH levels gradually decreased until 6[SUP]th[/SUP] month of follow-up compared to baseline (p < 0.001). A significant increase in serum AMH level was observed at 9[SUP]th[/SUP] month of follow-up compared to 6[SUP]th[/SUP] month follow-up levels (p < 0.001). The decrease in serum AMH level was statistically significant regardless of serum anti SARS-CoV-2 antibody levels, subgroups of age, occupation, menstrual dysregulation following vaccination and presence of gynaecological diseases. In conclusion, vaccination against SARS-CoV-2 causes a transient decrease on serum AMH levels and moderate irregularities in menstrual pattern increasing with age and is mostly reversible.
Keywords: Anti-mullerian hormone; COVID-19 vaccine; Pfizer-biontech; menstrual cycle; sinovac-coronavac.
. 2023 Mar 15;1-9.
doi: 10.1080/14647273.2023.2181710. Online ahead of print.
The effect of COVID-19 vaccinations on menstrual cycle and serum anti-Mullerian hormone levels in reproductive age women
Pinar Solmaz Hasdemir[SUP] 1 [/SUP], Sebnem Senol Akar[SUP] 2 [/SUP], Asli Goker[SUP] 1 [/SUP], Funda Kosova[SUP] 3 [/SUP], Duygu Ucar[SUP] 1 [/SUP], Funda Seher Ozalp Ates[SUP] 4 [/SUP], Sinem Akcali[SUP] 5 [/SUP]
Affiliations
- PMID: 36919413
- DOI: 10.1080/14647273.2023.2181710
Abstract
The aim of this prospective cohort study was to investigate the effect of coronavirus disease 2019 (COVID-19) vaccinations on menstrual cycle and ovarian reserve in reproductive aged-women. Health care providers (n = 258) vaccinated with inactivated (CoronaVac) and mRNA based (Pfizer-BioNTech®) COVID-19 vaccines were included. All subjects completed a gynaecological and menstrual history questionnaire and Anti-Mullerian Hormone (AMH) levels were measured in serum samples collected before first vaccination and at 1[SUP]st[/SUP], 3[SUP]rd[/SUP], 6[SUP]th[/SUP] and 9[SUP]th[/SUP] months. The prevalence of new-onset menstrual dysregulation following vaccination was 20.6% and it was statistically significant compared to baseline (p = 0.001). Menstrual pattern turned back to normal in 59.6% of vaccinated women. Serum AMH levels gradually decreased until 6[SUP]th[/SUP] month of follow-up compared to baseline (p < 0.001). A significant increase in serum AMH level was observed at 9[SUP]th[/SUP] month of follow-up compared to 6[SUP]th[/SUP] month follow-up levels (p < 0.001). The decrease in serum AMH level was statistically significant regardless of serum anti SARS-CoV-2 antibody levels, subgroups of age, occupation, menstrual dysregulation following vaccination and presence of gynaecological diseases. In conclusion, vaccination against SARS-CoV-2 causes a transient decrease on serum AMH levels and moderate irregularities in menstrual pattern increasing with age and is mostly reversible.
Keywords: Anti-mullerian hormone; COVID-19 vaccine; Pfizer-biontech; menstrual cycle; sinovac-coronavac.