gsgs
Registered User
http://www.sciencedirect.com/scienc...serid=10&md5=a59ae78ecc72fad82efe5242fe4475fc
Received 17 March 2003; accepted 10 August 2004. Available online 22 September 2004.
...We use a theory from statistical mechanics to quantify the non-monotonic immune response
that results from antigenic drift in the epitopes of the hemagglutinin and neuraminidase proteins.
The results explain the ineffectiveness of the 2003?2004 influenza vaccine in the United States
and provide an accurate measure by which to optimize the effectiveness of future annual
influenza vaccines.
Keywords: Influenza vaccine; Original antigenic sin; Antigenic drift
Received 17 March 2003; accepted 10 August 2004. Available online 22 September 2004.
...We use a theory from statistical mechanics to quantify the non-monotonic immune response
that results from antigenic drift in the epitopes of the hemagglutinin and neuraminidase proteins.
The results explain the ineffectiveness of the 2003?2004 influenza vaccine in the United States
and provide an accurate measure by which to optimize the effectiveness of future annual
influenza vaccines.
Keywords: Influenza vaccine; Original antigenic sin; Antigenic drift
