tetano
Editor, Senior Moderator
Curr Opin Virol. 2013 Aug 8. pii: S1879-6257(13)00129-6. doi: 10.1016/j.coviro.2013.07.005. [Epub ahead of print]
Host genetic determinants of influenza pathogenicity.
Lin TY, Brass AL.
Source
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, United States.
Abstract
Despite effective vaccines, influenza remains a major global health threat due to the morbidity and mortality caused by seasonal epidemics, as well as the 2009 pandemic. Also of profound concern are the rare but potentially catastrophic transmissions of avian influenza to humans, highlighted by a recent H7N9 influenza outbreak. Murine and human studies reveal that the clinical course of influenza is the result of a combination of both host and viral genetic determinants. While viral pathogenicity has long been the subject of intensive efforts, research to elucidate host genetic determinants, particularly human, is now in the ascendant, and the goal of this review is to highlight these recent insights.
Copyright ? 2013 Elsevier B.V. All rights reserved.
PMID:
23933004
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23933004
Host genetic determinants of influenza pathogenicity.
Lin TY, Brass AL.
Source
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, United States.
Abstract
Despite effective vaccines, influenza remains a major global health threat due to the morbidity and mortality caused by seasonal epidemics, as well as the 2009 pandemic. Also of profound concern are the rare but potentially catastrophic transmissions of avian influenza to humans, highlighted by a recent H7N9 influenza outbreak. Murine and human studies reveal that the clinical course of influenza is the result of a combination of both host and viral genetic determinants. While viral pathogenicity has long been the subject of intensive efforts, research to elucidate host genetic determinants, particularly human, is now in the ascendant, and the goal of this review is to highlight these recent insights.
Copyright ? 2013 Elsevier B.V. All rights reserved.
PMID:
23933004
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23933004