tetano
Editor, Senior Moderator
J Virol. 2019 Aug 7. pii: JVI.00797-19. doi: 10.1128/JVI.00797-19. [Epub ahead of print]
[h=1]Host factors impact vaccine efficacy: implications for seasonal and universal influenza vaccine programs.[/h] Dhakal S[SUP]1[/SUP], Klein SL[SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h] 1 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, 21205. 2 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, 21205 sklein2@jhu.edu. 3 Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, 21205.
[h=3]Abstract[/h] Influenza is a global public health problem. Current seasonal influenza vaccines have highly variable efficacy and hence attempts to develop broadly protective universal influenza vaccines with durable protection are underway. While much attention is given to the virus-related factors contributing to inconsistent vaccine responses, host-associated factors are often neglected. Growing evidences suggest that host factors including age, biological sex, pregnancy, and immune history play important roles as modifier of influenza virus vaccine efficacy. We hypothesize that host genetics, the hormonal milieu, and gut microbiota contribute to host-related differences in influenza virus vaccine efficacy. This review highlights the current insights and future perspectives into host-specific factors that impact influenza vaccine-induced immunity and protection. Consideration of the host factors that affect influenza vaccine-induced immunity might improve influenza vaccines by providing empirical evidence for optimizing or even personalizing vaccine type, dose, and use of adjuvants for current seasonal and future universal influenza vaccines.
Copyright ? 2019 American Society for Microbiology.
PMID: 31391269 DOI: 10.1128/JVI.00797-19
[h=1]Host factors impact vaccine efficacy: implications for seasonal and universal influenza vaccine programs.[/h] Dhakal S[SUP]1[/SUP], Klein SL[SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h] 1 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, 21205. 2 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, 21205 sklein2@jhu.edu. 3 Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, 21205.
[h=3]Abstract[/h] Influenza is a global public health problem. Current seasonal influenza vaccines have highly variable efficacy and hence attempts to develop broadly protective universal influenza vaccines with durable protection are underway. While much attention is given to the virus-related factors contributing to inconsistent vaccine responses, host-associated factors are often neglected. Growing evidences suggest that host factors including age, biological sex, pregnancy, and immune history play important roles as modifier of influenza virus vaccine efficacy. We hypothesize that host genetics, the hormonal milieu, and gut microbiota contribute to host-related differences in influenza virus vaccine efficacy. This review highlights the current insights and future perspectives into host-specific factors that impact influenza vaccine-induced immunity and protection. Consideration of the host factors that affect influenza vaccine-induced immunity might improve influenza vaccines by providing empirical evidence for optimizing or even personalizing vaccine type, dose, and use of adjuvants for current seasonal and future universal influenza vaccines.
Copyright ? 2019 American Society for Microbiology.
PMID: 31391269 DOI: 10.1128/JVI.00797-19