tetano
Editor, Senior Moderator
Annu Rev Virol. 2019 Jul 5. doi: 10.1146/annurev-virology-092917-043339. [Epub ahead of print]
[h=1]Host Determinants of Influenza RNA Synthesis.[/h] Peacock TP[SUP]1[/SUP], Sheppard CM[SUP]1[/SUP], Staller E[SUP]1[/SUP], Barclay WS[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza viruses are a leading cause of seasonal and pandemic respiratory illness. Influenza is a negative-sense single-stranded RNA virus that encodes its own RNA-dependent RNA polymerase (RdRp) for nucleic acid synthesis. The RdRp catalyzes mRNA synthesis, as well as replication of the virus genome (viral RNA) through a complementary RNA intermediate. Virus propagation requires the generation of these RNA species in a controlled manner while competing heavily with the host cell for resources. Influenza virus appropriates host factors to enhance and regulate RdRp activity at every step of RNA synthesis. This review describes such host factors and summarizes our current understanding of the roles they play in viral synthesis of RNA. Expected final online publication date for the Annual Review of Virology Volume 6 is September 30, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
PMID: 31283439 DOI: 10.1146/annurev-virology-092917-043339
[h=1]Host Determinants of Influenza RNA Synthesis.[/h] Peacock TP[SUP]1[/SUP], Sheppard CM[SUP]1[/SUP], Staller E[SUP]1[/SUP], Barclay WS[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza viruses are a leading cause of seasonal and pandemic respiratory illness. Influenza is a negative-sense single-stranded RNA virus that encodes its own RNA-dependent RNA polymerase (RdRp) for nucleic acid synthesis. The RdRp catalyzes mRNA synthesis, as well as replication of the virus genome (viral RNA) through a complementary RNA intermediate. Virus propagation requires the generation of these RNA species in a controlled manner while competing heavily with the host cell for resources. Influenza virus appropriates host factors to enhance and regulate RdRp activity at every step of RNA synthesis. This review describes such host factors and summarizes our current understanding of the roles they play in viral synthesis of RNA. Expected final online publication date for the Annual Review of Virology Volume 6 is September 30, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
PMID: 31283439 DOI: 10.1146/annurev-virology-092917-043339