tetano
Editor, Senior Moderator
Curr Top Microbiol Immunol. 2014 Jul 20. [Epub ahead of print]
Host Detection and the Stealthy Phenotype in Influenza Virus Infection.
Dash P1, Thomas PG.
Author information
Abstract
The innate host response to influenza virus infection plays a critical role in determining the subsequent course of infection and the clinical outcome of disease. The host has a diverse array of detection and effector mechanisms that are able to recognize and initiate effective antiviral responses. In opposition, the virus utilizes a number of distinct mechanisms to evade host detection and effector activity in order to remain "stealthy" throughout its replication cycle. In this review, we describe these host and viral mechanisms, including the major pattern recognition receptor families (the TLRs, NLRs, and RLRs) in the host and the specific viral proteins such as NS1 that are key players in this interaction. Additionally, we explore nonreductive mechanisms of viral immune evasion and propose areas important for future inquiry.
PMID:
25038940
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25038940
Host Detection and the Stealthy Phenotype in Influenza Virus Infection.
Dash P1, Thomas PG.
Author information
Abstract
The innate host response to influenza virus infection plays a critical role in determining the subsequent course of infection and the clinical outcome of disease. The host has a diverse array of detection and effector mechanisms that are able to recognize and initiate effective antiviral responses. In opposition, the virus utilizes a number of distinct mechanisms to evade host detection and effector activity in order to remain "stealthy" throughout its replication cycle. In this review, we describe these host and viral mechanisms, including the major pattern recognition receptor families (the TLRs, NLRs, and RLRs) in the host and the specific viral proteins such as NS1 that are key players in this interaction. Additionally, we explore nonreductive mechanisms of viral immune evasion and propose areas important for future inquiry.
PMID:
25038940
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25038940