Hong Kong - Tamiflu "severely ineffective" - even double dosage

[Treyfish]

(Star Island) December 22, 2009 Tuesday 05:30
(Roundup)

(Sing Tao Daily reported) at any time reached the second wave of human swine influenza in Hong Kong, Hong Kong University-virus expert Yuen Kwok-yung authoritative new study released yesterday found that Tamiflu is only for minor cases and fever within 48 hours of effective, a number of serious cases of swine influenza virus is not attacks the lungs, but also cause severe inflammation of the heart, acute myocarditis, pleural effusion, vascular infarction and other malignant diseases; the other bone marrow of patients also found that individual macrophages, even double Tamiflu prescriptions is also invalid. The results will be published early next year, "Clinical Infectious Diseases journal."

Reporter: Yang, Yuzhu

University of Hong Kong and Queen Mary Hospital and 12 hospital doctors co-operation analysis includes 11 public hospital and a private hospital in cases of severe and mild cases than the 37 cases.

Severe cases, 23 people have severe respiratory failure secondary to intubation or ventilator, most of the time more than 14 to the hospital on the 30th, in which 13 people were killed and two were described as non-risk factors in healthy individuals.

Yuen Kwok-yung, the study found cause of death in patients with critical or important reason is that inflammatory response. Now, with the effectiveness of antiviral drugs for treatment of swine influenza is not ideal, Tamiflu is only for minor cases, and only valid for 48 hours in patients with fever, but many serious cases have onset of the disease five to seven days after admission, Tamiflu has no effect.

University of Hong Kong Yuen Kwok-yung, Head of the Department of Microbiology, according to Australia, Canada, outbreaks and laboratory, we estimate that there will be a second wave of 2-300 people have died of swine influenza, of which about two free of risk factors, and therefore urged the public vaccinated, Yuan said: "Prevention is better than cure, they do not die, we are the best idea is to use vaccine to prevent it happen!"

The study also found that the seventh day after the onset of mild cases, the virus volume has dropped drastically, Yuen Kwok-yung said: "The serious cases, go to the 11th days there are many viruses, it is not been found before, whether to the double Tamiflu or Relenza, the virus is still very slow rate of decline, inflammation response factor is still rising. "

Yesterday by a dead one in critical condition

Analysis of three serious cases, including the United Christian Hospital a death is a serious lung water bubbles, combined with a lot of alveolar walls caused by inflammation of the white blood cells, died under the patient could not breathe. Another death from the Princess Margaret Hospital, part of the cardiac anatomy was found dead there are many white blood cells, indicating myocardial cells have died, finally died due to acute myocarditis.

Yuen Kwok-yung, said: "Recently, a number of cases is a very young age, died of acute myocarditis when the heart suddenly bounce, no way to pump the patient a good easy to die."

Another individual was found in patients with bone marrow macrophages, eat a lot of red blood cells, white blood cells, Yuen Kwok-yung said: "The blood of the induced inflammatory response factor was so high that it is discouraging eating of unhygienic things, the situation in the H5N1 (bird flu) infection can see. In severe swine influenza patients, because of the virus to stimulate the inflammatory response caused by very serious happened 『proliferation of mononuclear phagocytes and macrophage hyperlipidemia』 phenomenon, leading to acute myocarditis. "

In addition, our last new one death and one swine influenza critical cases, the deceased was a risk of heart disease, hypertension and high cholesterol 57-year-old male patient, critical case that is a good track record of the thirty-year-old healthy woman. :tiphat:http://hk.news.yahoo.com/article/091221/3/fri2.html

 

[Treyfish]

Re: Tamiflu severe ineffective

Re: Tamiflu severe ineffective

Flow of the dead pigs infected lung hit like H5N1
This article focuses on
Lo Wing-lok H-inflate the effectiveness of the vaccine
The second wave of the epidemic is expected to kill more than 300 people
Hong Kong University of swine influenza research


WASHINGTON University of Hong Kong for the first time in patients with severe swine influenza study found seriously ill patients to use double Tamiflu, efficacy is still unsatisfactory, the virus is very slow decline in the number, a serious inflammation of the dead is even more similar to avian influenza H5N1 . University of Hong Kong Yuen Kwok-yung, Head of the Department of Microbiology, seriously ill, the two become non-high-risk persons, the proposed four, 50-year-old if not older people who belong to high-risk category, should be vaccinated swine flu vaccine, "If there vaccinations can actually essential expenditures die, even if infected with swine flu, would be so serious that not even death. "
Lo Wing-lok H-inflate the effectiveness of the vaccine
Infectious disease specialist Lo Wing-lok criticized the scientific analysis of large outbreaks in Hong Kong, saying that even if there is no evidence that seasonal influenza vaccine hundred percent effectiveness, and not against swine influenza vaccine have the full protective effect, "no justification, then pin on a dozen stripped not even to die. " He believes that an analysis of Yuen Kwok-yung, "inflate the effectiveness of the vaccine, blowing big epidemic severe", there is confusion of people. CHP, Dr Thomas Tsang refers to, Tamiflu and Relenza are still valid; Acting Secretary for Food and Health Bureau, Gabriel Matthew Leung, refers to non-high-risk persons should decide whether or not vaccinated.

University of Hong Kong and Queen Mary Hospital in collaboration with 12 public and private hospitals, compared to 37 severe swine influenza patients and 37 patients with mild disease. Seriously ill patients, Nian San severe respiratory failure who should be using a breathing machine, the end 13 people were killed. Dead serious damage to lung tissue, some patients had myocarditis, vascular infarction, and hyperlipidemia such as macrophages. Even for seriously ill patients with double quantity of Tamiflu or Relenza, the patient response is not satisfactory. Yuen Kwok-yung explained that Tamiflu within 48 hours onset of the disease using the most effective, but most severely ill patients admitted to hospital when the disease has been the fifth to seven days, so Tamiflu result is not significant.

The study also found that seriously ill patients, two as non-high-risk persons, with an average age of about 50 years old. Yuen Kwok-yung means that prevention is better than treatment, appealed to the public as soon as possible vaccination.

The second wave of the epidemic is expected to kill more than 300 people
According to overseas experience, he estimated that the second wave of swine influenza in the winter there will be 72-288 high-risk people were killed; non-high-risk persons may be as many as 56 people were killed.

Hong Kong, yesterday again and again a swine influenza deaths and one critical case. The deceased was a 57-year-old man, itself, had heart disease, high blood pressure and high cholesterol. The thirty-year-old female patient in critical condition had good health and on the 19th of this month at Queen Mary hospital the next day diagnosed condition worsened yesterday.

In addition, the Chinese University of Hsu Shu-chang, director of Respiratory Medicine, said swine flu seriously ill patients served through a gastric tube Tamiflu have the opportunity to defecate vomiting and other side effects occur, and the drugs through the stomach into the blood by the gastrointestinal absorption of the concentration, so the Chinese University the introduction of new drugs, "peramivir" injections to treat pneumonia, or asthma and other symptoms of swine flu seriously ill patients. University is working with pharmaceutical companies for clinical studies using the drug drafting a written agreement is expected early next year at the New Territories East, three public hospitals.

Hong Kong University of swine influenza research
Study

‧ 37 Ming swine influenza in patients with mild

‧ 37 patients who had seriously swine influenza

‧ which 23 were severe respiratory failure and eventually 13 people were killed

Symptoms of the deceased

‧ lung tissue has been severely damaged

‧ myocarditis

‧ Infarction

‧ proliferation of mononuclear phagocytes and continue to eat red blood cells

‧ situation is similar to H5N1 avian influenza

Important discovery

‧ severely ill patient, no satisfactory response to the double Tamiflu

‧ slow decline in the number of severely ill patient, the virus

‧ severely ill patient, the body's inflammatory response factor is very high, inflammation of the situation is more serious

Source: University of Hong Kong Yuen Kwok-yung :tiphat:http://orientaldaily.on.cc/cnt/news/20091222/00176_027.html?pubdate=20091222

 

[Treyfish]

Re: Hong Kong - Tamiflu "severe ineffective" - even double dosage

Re: Hong Kong - Tamiflu "severe ineffective" - even double dosage

A flow of dangerous H5N1 Well I'd die like rotten lungs
Vaccination Subsidy confusing urged to be vaccinated for the elderly sub -
2009-12-22
By Ann Scott Tyson Reuters

December 21 the Government started five high-risk persons Influenza H1N1 influenza vaccine injection. Studies have shown that influenza A H1N1 influenza virus lethal surprising, vaccination is the only way to prevent it.


Influenza A H1N1 influenza virus lethal surprising. Head of Department of Microbiology, University of Hong Kong Yuen Kwok-yung (left) Model A flow injection of the vaccine, the proposed high-risk persons vaccinated as soon as possible.

Influenza H1N1 influenza virus lethal surprising, a study showed Tamiflu, Relenza for a severely ill patient ineffective. Head of the Department of Microbiology University of Hong Kong, said Yuen Kwok-yung, a severely ill patient's viral load decline was slow, but the cause of natural inflammatory factors is very high, serious damage to organs, the situation with the avian flu "H5N1" virus-like, we recommend a high-risk people vaccinated as soon as possible type H1N1 influenza vaccines.

University of Hong Kong recently in conjunction with the 11 public hospitals and one private hospital study compared 37 severe patients and 37 patients with mild situation. Yuen Kwok-yung said the 37 severe patients, no risk factors into two, of which 23 had severe respiratory failure, 13 of whom need to "intubation", but in the end, has died, "The remaining 10 people who, though not dead However, lung function has been seriously damaged, "subject to three to six months time to observe.

Hypoxia can cause lung water death

Research shows that 13 organs of the deceased by the virus attack, a natural inflammatory response is very serious, the situation with the risk of "H5N1" bird flu similar to. Yuen Kwok-yung said that their severely damaged lung tissue, there lungs bubble water, there are signs of inflammation, so patients "not able to meet gas permeability," oxygen-starved dead. In addition to the lung under attack, the heart muscle tissue is also inflamed the situation, in the heart There are many white blood cells, that is, acute myocarditis, so that normal cell death, the estimated number of recent cases of young deaths may be related to this. He said that the patient's bone marrow samples and found that mononuclear phagocytic cell hyperplasia and bite hyperlipidemia.

At the same time, research shows that even though patients have been prescribed Tamiflu, Relenza, the treatment is not ideal. Yuen Kwok-yung, and their slow decline in respiratory virus, when the virus down, the natural inflammatory response factor remains high, serious damage to lung tissue, to make Tamiflu, Relenza treatment effect is low, but in the meantime an unknown reason, does not exclude high-risk factors, the hospital too late. He said, Tamiflu, Relenza for treatment of mild cases is very effective, especially within 48 hours, but many severely ill patient on admission, it is already five to seven days after onset, even if the prescription of the double anti-influenza drugs, the role of not Great. As for the best treatment for a severely ill patient, he said that warrants further study is not yet known program, stressed that they would continue to seek better treatment.

Vaccinated as soon as possible that can be prevented

Anti-influenza drug therapy is not satisfactory, influenza A H1N1 influenza vaccine inoculation is the only way to prevent it. Yuen Kwok-yung said, "These deaths, in fact, no one needs to die", if they vaccination Influenza H1N1 influenza vaccine can prevent viruses. He cited data that Canada and Australia, it is estimated the epidemic comes the second wave, there may be 14-56 healthy people were killed, the death toll may be high-risk groups of up to 72-288 people. He called for high-risk persons should be vaccinated as soon as possible. :tiphat:http://www.takungpao.com.hk/news/09/12/22/zhuliugan01-1190667.htm

 

[Laidback Al]

Re: Hong Kong - Tamiflu "severely ineffective" - even double dosage

When doctors and researchers in Hong Kong compare the similarity of the clinical presentation of H1N1 fatalities with fatalities from H5N1, the world should take notice. They have a basis for comparison.

In 1997, in Hong Kong, the first known human H5N1 infections were confirmed in about 19 patients, of those, at least 6 died.

http://www.journals.uchicago.edu/doi/abs/10.1086/338820