tetano
Editor, Senior Moderator
HLA
. 2020 Nov 12.
doi: 10.1111/tan.14135. Online ahead of print.
Association of HLA-B22 serotype with SARS-CoV-2 susceptibility in Hong Kong Chinese patients
Yuk-Lin Yung[SUP] 1 [/SUP], Chi-Keung Cheng[SUP] 1 [/SUP], Hoi-Yun Chan[SUP] 1 [/SUP], Jenny T Xia[SUP] 1 [/SUP], Kin-Mang Lau[SUP] 1 [/SUP], Raymond S M Wong[SUP] 2 3 [/SUP], Alan K L Wu[SUP] 4 [/SUP], Raymond W Chu[SUP] 4 [/SUP], Alice C C Wong[SUP] 5 [/SUP], Eudora Y D Chow[SUP] 5 [/SUP], Sze-Fai Yip[SUP] 6 [/SUP], Jennifer N S Leung[SUP] 7 [/SUP], Cheuk-Kwong Lee[SUP] 7 [/SUP], Margaret H L Ng[SUP] 1 8 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) is a highly infectious disease caused by SARS-CoV-2. Since its first report in December 2019, COVID-19 has evolved into a global pandemic causing massive healthcare and socio-economic challenges. HLA system is critical in mediating anti-viral immunity and recent studies have suggested preferential involvement of HLA-B in COVID-19 susceptibility. Here, by investigating the HLA-B genotypes in 190 unrelated Chinese patients with confirmed COVID-19, we identified a significant positive association between the B22 serotype and SARS-CoV-2 infection (P=0.002, Bonferroni-corrected P=0.032). Notably, the B22 serotype has been consistently linked to susceptibility to other viral infections. These data not only shed new insights into SARS-CoV-2 pathogenesis and vaccine development but also guide better infection prevention/control. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Chinese; HLA; SARS-CoV-2; coronavirus.
. 2020 Nov 12.
doi: 10.1111/tan.14135. Online ahead of print.
Association of HLA-B22 serotype with SARS-CoV-2 susceptibility in Hong Kong Chinese patients
Yuk-Lin Yung[SUP] 1 [/SUP], Chi-Keung Cheng[SUP] 1 [/SUP], Hoi-Yun Chan[SUP] 1 [/SUP], Jenny T Xia[SUP] 1 [/SUP], Kin-Mang Lau[SUP] 1 [/SUP], Raymond S M Wong[SUP] 2 3 [/SUP], Alan K L Wu[SUP] 4 [/SUP], Raymond W Chu[SUP] 4 [/SUP], Alice C C Wong[SUP] 5 [/SUP], Eudora Y D Chow[SUP] 5 [/SUP], Sze-Fai Yip[SUP] 6 [/SUP], Jennifer N S Leung[SUP] 7 [/SUP], Cheuk-Kwong Lee[SUP] 7 [/SUP], Margaret H L Ng[SUP] 1 8 [/SUP]
Affiliations
- PMID: 33179437
- DOI: 10.1111/tan.14135
Abstract
The coronavirus disease 2019 (COVID-19) is a highly infectious disease caused by SARS-CoV-2. Since its first report in December 2019, COVID-19 has evolved into a global pandemic causing massive healthcare and socio-economic challenges. HLA system is critical in mediating anti-viral immunity and recent studies have suggested preferential involvement of HLA-B in COVID-19 susceptibility. Here, by investigating the HLA-B genotypes in 190 unrelated Chinese patients with confirmed COVID-19, we identified a significant positive association between the B22 serotype and SARS-CoV-2 infection (P=0.002, Bonferroni-corrected P=0.032). Notably, the B22 serotype has been consistently linked to susceptibility to other viral infections. These data not only shed new insights into SARS-CoV-2 pathogenesis and vaccine development but also guide better infection prevention/control. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Chinese; HLA; SARS-CoV-2; coronavirus.