tetano
Editor, Senior Moderator
J Infect Dis. 2015 Jan 2. pii: jiu840. [Epub ahead of print]
[h=1]HIV infection worsens Age-Associated Defects in Antibody Responses to Influenza Vaccine.[/h] George VK[SUP]1[/SUP], Pallikkuth S[SUP]1[/SUP], Parmigiani A[SUP]2[/SUP], Alcaide M[SUP]3[/SUP], Fischl M[SUP]4[/SUP], Arheart KL[SUP]5[/SUP], Pahwa S[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Antibody responses to seasonal influenza vaccines are defective in old age and in human immunodeficiency virus (HIV)-infection. The effect of HIV on immune function in aging is relatively unknown.
[h=4]METHODS:[/h] HIV-infected and HIV-uninfected young and old women were evaluated for B and T cellular responses pre- and 4 weeks post-influenza vaccination.
[h=4]RESULTS:[/h] Seroprotection at pre-vaccination and vaccine responsiveness (>4 fold increase in antibody titer) were lower in HIV-infected than age-matched HIV-uninfected participants. A subgroup of vaccine non-responders were compared with responders and found to have reduced frequencies of memory B cells and antigen-specific antibody secreting cells post-vaccination. Frequencies of peripheral T follicular helper (pTfh) cells correlated with memory B cell function and influenza H1N1 antibody titers. Serologic and immunologic deficits were most frequent in old HIV-infected participants. Underlying CD4 T cell immune activation and inflammation correlated negatively with antibody titers and B cell function which was not enhanced by exogenous IL-21 supplementation in HIV-infected old vaccine non-responders.
[h=4]CONCLUSION:[/h] Immune activation associated with HIV infection, and impaired pTfh function heighten deficiencies in antibody responses to influenza vaccine in aging. Strategies to reduce immune activation or augment pTfh function may enhance antibody responses in the aging HIV-infected population.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 25556252 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25556252
[h=1]HIV infection worsens Age-Associated Defects in Antibody Responses to Influenza Vaccine.[/h] George VK[SUP]1[/SUP], Pallikkuth S[SUP]1[/SUP], Parmigiani A[SUP]2[/SUP], Alcaide M[SUP]3[/SUP], Fischl M[SUP]4[/SUP], Arheart KL[SUP]5[/SUP], Pahwa S[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Antibody responses to seasonal influenza vaccines are defective in old age and in human immunodeficiency virus (HIV)-infection. The effect of HIV on immune function in aging is relatively unknown.
[h=4]METHODS:[/h] HIV-infected and HIV-uninfected young and old women were evaluated for B and T cellular responses pre- and 4 weeks post-influenza vaccination.
[h=4]RESULTS:[/h] Seroprotection at pre-vaccination and vaccine responsiveness (>4 fold increase in antibody titer) were lower in HIV-infected than age-matched HIV-uninfected participants. A subgroup of vaccine non-responders were compared with responders and found to have reduced frequencies of memory B cells and antigen-specific antibody secreting cells post-vaccination. Frequencies of peripheral T follicular helper (pTfh) cells correlated with memory B cell function and influenza H1N1 antibody titers. Serologic and immunologic deficits were most frequent in old HIV-infected participants. Underlying CD4 T cell immune activation and inflammation correlated negatively with antibody titers and B cell function which was not enhanced by exogenous IL-21 supplementation in HIV-infected old vaccine non-responders.
[h=4]CONCLUSION:[/h] Immune activation associated with HIV infection, and impaired pTfh function heighten deficiencies in antibody responses to influenza vaccine in aging. Strategies to reduce immune activation or augment pTfh function may enhance antibody responses in the aging HIV-infected population.
? The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
PMID: 25556252 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25556252