tetano
Editor, Senior Moderator
Transbound Emerg Dis. 2016 Jan 8. doi: 10.1111/tbed.12470. [Epub ahead of print]
[h=1]Highly Pathogenic Avian Influenza Virus A/H5N1 Infection in Vaccinated Meat Duck Flocks in the Mekong Delta of Vietnam.[/h] Cuong NV[SUP]1[/SUP], Truc VN[SUP]1,[/SUP][SUP]2[/SUP], Nhung NT[SUP]1[/SUP], Thanh TT[SUP]1[/SUP], Chieu TT[SUP]1[/SUP], Hieu TQ[SUP]3[/SUP], Men NT[SUP]3[/SUP], Mai HH[SUP]3[/SUP], Chi HT[SUP]3[/SUP], Boni MF[SUP]1,[/SUP][SUP]4[/SUP], van Doorn HR[SUP]1,[/SUP][SUP]4[/SUP], Thwaites GE[SUP]1,[/SUP][SUP]4[/SUP], Carrique-Mas JJ[SUP]1,[/SUP][SUP]4[/SUP], Hoa NT[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We investigated episodes of suspected highly pathogenic avian influenza (HPAI)-like illness among 12 meat duck flocks in two districts in Tien Giang province (Mekong Delta, Vietnam) in November 2013. In total, duck samples from 8 of 12 farms tested positive for HPAI virus subtype A/haemagglutinin 5 and neuraminidase 1 (H5N1) by real-time RT-PCR. Sequencing results confirmed clade of 2.3.2.1.c as the cause of the outbreaks. Most (7/8) laboratory-confirmed positive flocks had been vaccinated with inactivated HPAI H5N1 clade 2.3.4 vaccines <6 days prior to onset of clinical signs. A review of vaccination data in relation to estimated production in the area suggested that vaccination efforts were biased towards larger flocks and that vaccination coverage was low [21.2% ducks vaccinated with two shots (range by district 7.4-34.9%)]. The low-coverage data, the experimental evidence of lack of cross-protection conferred by the currently used vaccines based on clade 2.3.4 together with the short lifespan of meat duck flocks (60-70 days), suggest that vaccination is not likely to be effective as a tool for control of H5N1 infection in meat duck flocks in the area.
? 2016 The Authors. Transboundary and Emerging Diseases Published by Blackwell Verlag GmbH.
[h=4]KEYWORDS:[/h] H5N1; avian influenza virus; duck; one health; vaccine; veterinary epidemiology; zoonoses
PMID: 26748550 [PubMed - as supplied by publisher]
[h=1]Highly Pathogenic Avian Influenza Virus A/H5N1 Infection in Vaccinated Meat Duck Flocks in the Mekong Delta of Vietnam.[/h] Cuong NV[SUP]1[/SUP], Truc VN[SUP]1,[/SUP][SUP]2[/SUP], Nhung NT[SUP]1[/SUP], Thanh TT[SUP]1[/SUP], Chieu TT[SUP]1[/SUP], Hieu TQ[SUP]3[/SUP], Men NT[SUP]3[/SUP], Mai HH[SUP]3[/SUP], Chi HT[SUP]3[/SUP], Boni MF[SUP]1,[/SUP][SUP]4[/SUP], van Doorn HR[SUP]1,[/SUP][SUP]4[/SUP], Thwaites GE[SUP]1,[/SUP][SUP]4[/SUP], Carrique-Mas JJ[SUP]1,[/SUP][SUP]4[/SUP], Hoa NT[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We investigated episodes of suspected highly pathogenic avian influenza (HPAI)-like illness among 12 meat duck flocks in two districts in Tien Giang province (Mekong Delta, Vietnam) in November 2013. In total, duck samples from 8 of 12 farms tested positive for HPAI virus subtype A/haemagglutinin 5 and neuraminidase 1 (H5N1) by real-time RT-PCR. Sequencing results confirmed clade of 2.3.2.1.c as the cause of the outbreaks. Most (7/8) laboratory-confirmed positive flocks had been vaccinated with inactivated HPAI H5N1 clade 2.3.4 vaccines <6 days prior to onset of clinical signs. A review of vaccination data in relation to estimated production in the area suggested that vaccination efforts were biased towards larger flocks and that vaccination coverage was low [21.2% ducks vaccinated with two shots (range by district 7.4-34.9%)]. The low-coverage data, the experimental evidence of lack of cross-protection conferred by the currently used vaccines based on clade 2.3.4 together with the short lifespan of meat duck flocks (60-70 days), suggest that vaccination is not likely to be effective as a tool for control of H5N1 infection in meat duck flocks in the area.
? 2016 The Authors. Transboundary and Emerging Diseases Published by Blackwell Verlag GmbH.
[h=4]KEYWORDS:[/h] H5N1; avian influenza virus; duck; one health; vaccine; veterinary epidemiology; zoonoses
PMID: 26748550 [PubMed - as supplied by publisher]