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http://www.jimmunol.org/cgi/content/abstract/179/8/5220
The Journal of Immunology, 2007, 179: 5220-5227.
Copyright © 2007 by The American Association of Immunologists, Inc.
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High Susceptibility of Human Dendritic Cells to Avian Influenza H5N1 Virus Infection and Protection by IFN-
and TLR Ligands<SUP>1</SUP>
</NOBR><NOBR>Arunee Thitithanyanont<SUP>*</SUP></NOBR>, <NOBR>Anneke Engering<SUP>
</SUP></NOBR>, <NOBR>Peeraya Ekchariyawat<SUP>*</SUP></NOBR>, <NOBR>Suwimon Wiboon-ut<SUP>*</SUP></NOBR>, <NOBR>Amporn Limsalakpetch<SUP>
</SUP></NOBR>, <NOBR>Kosol Yongvanitchit<SUP>
</SUP></NOBR>, <NOBR>Utaiwan Kum-Arb<SUP>
</SUP></NOBR>, <NOBR>Watcharoot Kanchongkittiphon<SUP>*</SUP><SUP>,
</SUP></NOBR>, <NOBR>Pongsak Utaisincharoen<SUP>*</SUP></NOBR>, <NOBR>Stitaya Sirisinha<SUP>*</SUP></NOBR>, <NOBR>Pilaipan Puthavathana<SUP>
</SUP></NOBR>, <NOBR>Mark M. Fukuda<SUP>
</SUP></NOBR> and <NOBR>Sathit Pichyangkul<SUP>2</SUP><SUP>,
</SUP></NOBR>
[SIZE=-1]<SUP>*</SUP> Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand; <SUP>
</SUP> Department of Immunology and Medicine and <SUP>
</SUP> Department of Enteric Diseases, U.S. Army Medical Component of the Armed Forces Research Institute of the Medical Sciences, Bangkok, Thailand; and <SUP>
</SUP> Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand [/SIZE]
<!-- ABS -->There is worldwide concern that the avian influenza H5N1 virus,<SUP> </SUP>with a mortality rate of >50%, might cause the next influenza<SUP> </SUP>pandemic. Unlike most other influenza infections, H5N1 infection<SUP> </SUP>causes a systemic disease. The underlying mechanisms for this<SUP> </SUP>effect are still unclear. In this study, we investigate the<SUP> </SUP>interplay between avian influenza H5N1 and human dendritic cells<SUP> </SUP>(DC). We showed that H5N1 virus can infect and replicate in<SUP> </SUP>monocyte-derived and blood myeloid DC, leading to cell death.<SUP> </SUP>These results suggest that H5N1 escapes viral-specific immunity,<SUP> </SUP>and could disseminate via DC. In contrast, blood pDC were resistant<SUP> </SUP>to infection and produced high amounts of IFN-
. Addition of<SUP> </SUP>this cytokine to monocyte-derived DC or pretreatment with TLR<SUP> </SUP>ligands protected against infection and the cytopathic effects<SUP> </SUP>of H5N1 virus.<SUP> </SUP>
<!-- FN --><!-- null -->The costs of publication of this article were defrayed in part<SUP> </SUP>by the payment of page charges. This article must therefore<SUP> </SUP>be hereby marked advertisement in accordance with 18 U.S.C.<SUP> </SUP>Section 1734 solely to indicate this fact.<SUP> </SUP>
<!-- null --><SUP>1</SUP> This work was supported by the National Center for Genetic Engineering<SUP> </SUP>and Biotechnology (BIOTEC) Thailand, the Ellison Medical Foundation<SUP> </SUP>prime grant, by Thailand Research Fund for Advanced Research<SUP> </SUP>Scholar, and by Grant Y1-AI-5026-01 from the National Institutes<SUP> </SUP>of Health, National Institute of Allergy and Infectious Diseases<SUP> </SUP>International Research in Infectious Disease.<SUP> </SUP>
<!-- null --><SUP>2</SUP> Address correspondence and reprint requests to Dr. Sathit Pichyangkul,<SUP> </SUP>Department of Immunology and Medicine, U.S. Army Medical Component<SUP> </SUP>of the Armed Forces Research Institute of the Medical Sciences,<SUP> </SUP>315/6 Rajvithi Road, Bangkok 10400, Thailand. E-mail address:<SUP> </SUP>sathitp@afrims.org<SCRIPT type=text/javascript><!-- var u = "sathitp", d = "afrims.org"; document.getElementById("em0").innerHTML = '<a href="mailto:' + u + '@' + d + '">' + u + '@' + d + '<\/a>'//--></SCRIPT> <SUP></SUP><!-- null --><SUP>3</SUP> Abbreviations used in this paper: DC, dendritic cell; mDC, myeloid<SUP> </SUP>DC; pDC, plasmacytoid DC; MOI, multiplicity of infection.<SUP> </SUP>
<!-- / message --><!-- sig -->
This looks intersting.
http://www.jimmunol.org/cgi/content/abstract/179/8/5220
The Journal of Immunology, 2007, 179: 5220-5227.
Copyright © 2007 by The American Association of Immunologists, Inc.
<TABLE class=content_box_outer_table align=right><TBODY><TR><TD><!-- beginning of inner table --><TABLE class=content_box_inner_table><!-- citation --><TBODY><TR><TD class=content_box_title_highlight colSpan=2>This Article</TD></TR><TR><TD class=content_box_space_between_sections colSpan=2>
High Susceptibility of Human Dendritic Cells to Avian Influenza H5N1 Virus Infection and Protection by IFN-
</NOBR><NOBR>Arunee Thitithanyanont<SUP>*</SUP></NOBR>, <NOBR>Anneke Engering<SUP>
[SIZE=-1]<SUP>*</SUP> Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand; <SUP>
<!-- ABS -->There is worldwide concern that the avian influenza H5N1 virus,<SUP> </SUP>with a mortality rate of >50%, might cause the next influenza<SUP> </SUP>pandemic. Unlike most other influenza infections, H5N1 infection<SUP> </SUP>causes a systemic disease. The underlying mechanisms for this<SUP> </SUP>effect are still unclear. In this study, we investigate the<SUP> </SUP>interplay between avian influenza H5N1 and human dendritic cells<SUP> </SUP>(DC). We showed that H5N1 virus can infect and replicate in<SUP> </SUP>monocyte-derived and blood myeloid DC, leading to cell death.<SUP> </SUP>These results suggest that H5N1 escapes viral-specific immunity,<SUP> </SUP>and could disseminate via DC. In contrast, blood pDC were resistant<SUP> </SUP>to infection and produced high amounts of IFN-
<!-- FN --><!-- null -->The costs of publication of this article were defrayed in part<SUP> </SUP>by the payment of page charges. This article must therefore<SUP> </SUP>be hereby marked advertisement in accordance with 18 U.S.C.<SUP> </SUP>Section 1734 solely to indicate this fact.<SUP> </SUP>
<!-- null --><SUP>1</SUP> This work was supported by the National Center for Genetic Engineering<SUP> </SUP>and Biotechnology (BIOTEC) Thailand, the Ellison Medical Foundation<SUP> </SUP>prime grant, by Thailand Research Fund for Advanced Research<SUP> </SUP>Scholar, and by Grant Y1-AI-5026-01 from the National Institutes<SUP> </SUP>of Health, National Institute of Allergy and Infectious Diseases<SUP> </SUP>International Research in Infectious Disease.<SUP> </SUP>
<!-- null --><SUP>2</SUP> Address correspondence and reprint requests to Dr. Sathit Pichyangkul,<SUP> </SUP>Department of Immunology and Medicine, U.S. Army Medical Component<SUP> </SUP>of the Armed Forces Research Institute of the Medical Sciences,<SUP> </SUP>315/6 Rajvithi Road, Bangkok 10400, Thailand. E-mail address:<SUP> </SUP>sathitp@afrims.org<SCRIPT type=text/javascript><!-- var u = "sathitp", d = "afrims.org"; document.getElementById("em0").innerHTML = '<a href="mailto:' + u + '@' + d + '">' + u + '@' + d + '<\/a>'//--></SCRIPT> <SUP></SUP><!-- null --><SUP>3</SUP> Abbreviations used in this paper: DC, dendritic cell; mDC, myeloid<SUP> </SUP>DC; pDC, plasmacytoid DC; MOI, multiplicity of infection.<SUP> </SUP>
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