tetano
Editor, Senior Moderator
J Virol. 2015 Jan 14. pii: JVI.02871-14. [Epub ahead of print]
[h=1]High preexisting serological antibody levels correlate with diversification of the influenza vaccine response.[/h] Andrews SF[SUP]1[/SUP], Kaur K[SUP]2[/SUP], Pauli NT[SUP]2[/SUP], Huang M[SUP]1[/SUP], Huang Y[SUP]1[/SUP], Wilson PC[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Reactivation of memory B cells allows for a rapid and robust immune response upon challenge with the same antigen. Variant influenza strains generated through antigenic shift or drift are encountered multiple times over the lifetime of an individual. One might predict, then, that upon vaccination with the trivalent influenza vaccine across multiple years, the antibody response would become more and more dominant towards strains consistently present in the vaccine at the expense of more divergent strains. However, when we analyzed the vaccine-induced plasmablast, memory and serological response to the trivalent influenza vaccine between 2006 and 2013, we found that the B cell response was most robust against more divergent strains. Overall the antibody response was highest when one or more strains contained in the vaccine varied from year to year. This suggests that in the broader immunological context of viral antigen exposure, the B cell response to variant influenza strains is not dictated by the composition of the memory B cell precursor pool. The outcome is instead a diversified B cell response.
[h=4]IMPORTANCE:[/h] Vaccine strategies are being designed to boost broadly-reactive B cells present in the memory repertoire to provide universal protection to influenza. It is important to understand how past exposure to influenza strains affects the response to subsequent immunizations. The viral epitopes targeted by B cells responding to the vaccine may be a direct reflection of the B cell memory specificities abundant in the preexisting immune repertoire or other factors may influence the vaccine response. Herein we demonstrate that high preexisting serological antibody levels to a given influenza strain correlate with low production of antibody-secreting cells and memory B cells recognizing that strain upon revaccination. In contrast, introduction of antigenically novel strains generates a robust B cell response. Thus, both the preexisting memory B cell repertoire and serological antibody levels must be taken into consideration when predicting the quality of the B cell response to new prime-boost vaccine strategies.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 25589639 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25589639
[h=1]High preexisting serological antibody levels correlate with diversification of the influenza vaccine response.[/h] Andrews SF[SUP]1[/SUP], Kaur K[SUP]2[/SUP], Pauli NT[SUP]2[/SUP], Huang M[SUP]1[/SUP], Huang Y[SUP]1[/SUP], Wilson PC[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Reactivation of memory B cells allows for a rapid and robust immune response upon challenge with the same antigen. Variant influenza strains generated through antigenic shift or drift are encountered multiple times over the lifetime of an individual. One might predict, then, that upon vaccination with the trivalent influenza vaccine across multiple years, the antibody response would become more and more dominant towards strains consistently present in the vaccine at the expense of more divergent strains. However, when we analyzed the vaccine-induced plasmablast, memory and serological response to the trivalent influenza vaccine between 2006 and 2013, we found that the B cell response was most robust against more divergent strains. Overall the antibody response was highest when one or more strains contained in the vaccine varied from year to year. This suggests that in the broader immunological context of viral antigen exposure, the B cell response to variant influenza strains is not dictated by the composition of the memory B cell precursor pool. The outcome is instead a diversified B cell response.
[h=4]IMPORTANCE:[/h] Vaccine strategies are being designed to boost broadly-reactive B cells present in the memory repertoire to provide universal protection to influenza. It is important to understand how past exposure to influenza strains affects the response to subsequent immunizations. The viral epitopes targeted by B cells responding to the vaccine may be a direct reflection of the B cell memory specificities abundant in the preexisting immune repertoire or other factors may influence the vaccine response. Herein we demonstrate that high preexisting serological antibody levels to a given influenza strain correlate with low production of antibody-secreting cells and memory B cells recognizing that strain upon revaccination. In contrast, introduction of antigenically novel strains generates a robust B cell response. Thus, both the preexisting memory B cell repertoire and serological antibody levels must be taken into consideration when predicting the quality of the B cell response to new prime-boost vaccine strategies.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 25589639 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25589639