tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2018 Mar 2. doi: 10.1111/irv.12550. [Epub ahead of print]
[h=1]Heterogeneous estimates of influenza virus types A and B in the elderly: results of a meta-regression analysis.[/h] Panatto D[SUP]1,[/SUP][SUP]2[/SUP], Signori A[SUP]1[/SUP], Lai PL[SUP]1,[/SUP][SUP]2[/SUP], Gasparini R[SUP]1,[/SUP][SUP]2[/SUP], Amicizia D[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]AIM:[/h] Influenza has many age-dependent characteristics. A previous systematic review of randomized controlled trials showed that the detection rate of influenza B was higher in children than in non-elderly adults. However, no comprehensive reviews have targeted the elderly, who carry the main burden of disease. We aimed to quantify the relative detection rates of virus types A and B among the elderly, to identify factors affecting these proportions and to compare type distribution among seniors and younger age-classes.
[h=4]METHOD:[/h] A comprehensive literature search was conducted in order to identify multi-season studies reporting A and B virus type distributions in the elderly. A random-effects meta-analysis was planned to quantify the prevalence of type B among elderly subjects with laboratory-confirmed influenza. Meta-regression was then applied in order to explain the sources of heterogeneity.
[h=4]RESULTS:[/h] Across 27 estimates identified, the type B detection rate among seniors varied from 5% to 37%. Meta-analysis was not feasible owing to high heterogeneity (I[SUP]2[/SUP] =98.5%). Meta-regression analysis showed that study characteristics, such as number of seasons included, hemisphere and setting, could have contributed to the heterogeneity observed. The final adjusted model showed that studies that included both outpatients and inpatients reported a significantly (P=0.024) lower proportion than those involving outpatients only. The detection rate of type B among the elderly was generally lower than in children/adolescents, but not non-elderly adults.
[h=4]CONCLUSION:[/h] Influenza virus type B has a relatively low detection rate in older adults, especially in settings covering both inpatients and outpatients. Public health implications are discussed. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
PMID: 29498477 DOI: 10.1111/irv.12550
Free full text
[h=1]Heterogeneous estimates of influenza virus types A and B in the elderly: results of a meta-regression analysis.[/h] Panatto D[SUP]1,[/SUP][SUP]2[/SUP], Signori A[SUP]1[/SUP], Lai PL[SUP]1,[/SUP][SUP]2[/SUP], Gasparini R[SUP]1,[/SUP][SUP]2[/SUP], Amicizia D[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]AIM:[/h] Influenza has many age-dependent characteristics. A previous systematic review of randomized controlled trials showed that the detection rate of influenza B was higher in children than in non-elderly adults. However, no comprehensive reviews have targeted the elderly, who carry the main burden of disease. We aimed to quantify the relative detection rates of virus types A and B among the elderly, to identify factors affecting these proportions and to compare type distribution among seniors and younger age-classes.
[h=4]METHOD:[/h] A comprehensive literature search was conducted in order to identify multi-season studies reporting A and B virus type distributions in the elderly. A random-effects meta-analysis was planned to quantify the prevalence of type B among elderly subjects with laboratory-confirmed influenza. Meta-regression was then applied in order to explain the sources of heterogeneity.
[h=4]RESULTS:[/h] Across 27 estimates identified, the type B detection rate among seniors varied from 5% to 37%. Meta-analysis was not feasible owing to high heterogeneity (I[SUP]2[/SUP] =98.5%). Meta-regression analysis showed that study characteristics, such as number of seasons included, hemisphere and setting, could have contributed to the heterogeneity observed. The final adjusted model showed that studies that included both outpatients and inpatients reported a significantly (P=0.024) lower proportion than those involving outpatients only. The detection rate of type B among the elderly was generally lower than in children/adolescents, but not non-elderly adults.
[h=4]CONCLUSION:[/h] Influenza virus type B has a relatively low detection rate in older adults, especially in settings covering both inpatients and outpatients. Public health implications are discussed. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
PMID: 29498477 DOI: 10.1111/irv.12550
Free full text