Herquline A, produced by Penicillium herquei FKI-7215, exhibits anti-influenza virus properties

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Biosci Biotechnol Biochem. 2016 Mar 21:1-4. [Epub ahead of print]
[h=1]Herquline A, produced by Penicillium herquei FKI-7215, exhibits anti-influenza virus properties.[/h] Chiba T[SUP]1[/SUP], Asami Y[SUP]1,[/SUP][SUP]2[/SUP], Suga T[SUP]1[/SUP], Watanabe Y[SUP]1[/SUP], Nagai T[SUP]1,[/SUP][SUP]2[/SUP], Momose F[SUP]1,[/SUP][SUP]2[/SUP], Nonaka K[SUP]1,[/SUP][SUP]2[/SUP], Iwatsuki M[SUP]1,[/SUP][SUP]2[/SUP], Yamada H[SUP]1,[/SUP][SUP]2[/SUP], Ōmura S[SUP]2[/SUP], Shiomi K[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] In the course of screening for new anti-influenza virus antibiotics, we isolated herquline A from a culture broth of the fungus, Penicillium herquei FKI-7215. Herquline A inhibited replication of influenza virus A/PR/8/34 strain in a dose-dependent manner without exhibiting cytotoxicity against several human cell lines. It did not inhibit the viral neuraminidase.


[h=4]KEYWORDS:[/h] A/PR/8/34 strain; Penicillium herquei; herquline A; influenza virus

PMID: 26999706 [PubMed - as supplied by publisher]