Emily
Editor, Senior Moderator
Good thing he was fully vaccinated so he could get his liver transplant! Maybe the Greenpass should be renamed the Yellowpass, (for jaundice.)
https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32409
Letter to the editor: Liver transplantation following severe acute respiratory syndrome-coronavirus-2 vaccination–induced liver failure
Cumali Efe, Murat Harputluoğlu, Neşe Karadağ Soylu, Sezai Yilmaz
First published: 17 February 2022
https://doi.org/10.1002/hep.32409
To the editor,Several case reports have described development of liver injury following severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccination in Hepatology.[SUP][[/SUP][SUP]1, 2[/SUP][SUP]][/SUP] These cases showed autoimmune hepatitis (AIH) features, and all cases responded well to corticosteroid therapy. Herein, we present a patient who underwent liver transplantation due to fulminant liver failure following vaccination with the BioNTech vaccine.
A 53-year-old previously healthy man received a first dose of BioNTech vaccine on the June 5, 2021. Ten days after vaccination, he developed mild abdominal pain, erythematous skin eruption, and pruritus. Initial laboratory findings were alanine aminotransferase (ALT) 333 (upper limit of normal [ULN] 55 U/L), aspartate aminotransferase (AST) 168 (ULN 34 U/L), alkaline phosphatase 102 (ULN 150 U/L), and total bilirubin 0.8 (ULN 1.2 mg/dl). The patient’s symptoms were considered to be a hypersensitivity reaction. Oral antihistaminic therapy and topical steroids did not lead to clinical improvement. On day 18 after vaccination, prednisolone 32 mg/day for 10 days followed by 16 mg/day for 20 days was commenced. One week into the steroid course, symptoms significantly improved, and aminotransferases decreased (Figure 1).
The patient was reluctant to receive a second vaccine dose for fear of additional side effects but had travel plans and needed a full vaccination chart. He, therefore, scheduled a second Pfizer-BioNTech vaccine dose 6 weeks after the first dose. Following the second vaccination, similar symptoms reoccurred after a few days. The dose of prednisolone was increased to 32 mg/day, gradually tapered, and discontinued in mid-August 2021. One month after, he developed abdominal pain, myalgia, fatigue, and jaundice. The symptoms and laboratory findings did not improve over 10 days, and he was referred to a tertiary liver transplant center...
https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32409
Letter to the editor: Liver transplantation following severe acute respiratory syndrome-coronavirus-2 vaccination–induced liver failure
Cumali Efe, Murat Harputluoğlu, Neşe Karadağ Soylu, Sezai Yilmaz
First published: 17 February 2022
https://doi.org/10.1002/hep.32409
To the editor,Several case reports have described development of liver injury following severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccination in Hepatology.[SUP][[/SUP][SUP]1, 2[/SUP][SUP]][/SUP] These cases showed autoimmune hepatitis (AIH) features, and all cases responded well to corticosteroid therapy. Herein, we present a patient who underwent liver transplantation due to fulminant liver failure following vaccination with the BioNTech vaccine.
A 53-year-old previously healthy man received a first dose of BioNTech vaccine on the June 5, 2021. Ten days after vaccination, he developed mild abdominal pain, erythematous skin eruption, and pruritus. Initial laboratory findings were alanine aminotransferase (ALT) 333 (upper limit of normal [ULN] 55 U/L), aspartate aminotransferase (AST) 168 (ULN 34 U/L), alkaline phosphatase 102 (ULN 150 U/L), and total bilirubin 0.8 (ULN 1.2 mg/dl). The patient’s symptoms were considered to be a hypersensitivity reaction. Oral antihistaminic therapy and topical steroids did not lead to clinical improvement. On day 18 after vaccination, prednisolone 32 mg/day for 10 days followed by 16 mg/day for 20 days was commenced. One week into the steroid course, symptoms significantly improved, and aminotransferases decreased (Figure 1).
The patient was reluctant to receive a second vaccine dose for fear of additional side effects but had travel plans and needed a full vaccination chart. He, therefore, scheduled a second Pfizer-BioNTech vaccine dose 6 weeks after the first dose. Following the second vaccination, similar symptoms reoccurred after a few days. The dose of prednisolone was increased to 32 mg/day, gradually tapered, and discontinued in mid-August 2021. One month after, he developed abdominal pain, myalgia, fatigue, and jaundice. The symptoms and laboratory findings did not improve over 10 days, and he was referred to a tertiary liver transplant center...
