tetano
Editor, Senior Moderator
Hemoglobin
. 2023 Jun 16;1-12.
doi: 10.1080/03630269.2023.2219847. Online ahead of print. Case Fatality Rate and Severity of COVID-19 among Patients with Sickle Cell Disease: A Systematic Review and Meta-Analysis
Tarcísio Silva Borborema[SUP] 1 2 [/SUP], Julio Cesar Moreira Brito[SUP] 3 [/SUP], Edleusa Marques Lima Batista[SUP] 4 [/SUP], Rodrigo Siqueira Batista[SUP] 1 5 [/SUP]
Affiliations
The sickle cell disease (SCD) population has been considered particularly vulnerable to viral pandemics since the emergence of H1N1 in 2009. In this sense, the advance of the COVID-19 pandemic from 2020 has brought this group of patients to the center of concern. However, scientific knowledge about the susceptibility of patients with SCD to a severe COVID-19 pandemic is still insufficient, and efforts to establish a general profile of the disease in these patients, remain inadequate. The present study, therefore, sought to characterize the case fatality rate and severity of COVID-19 in patients with SCD throughout the world. A systematic review of Pubmed/MEDLINE, Scopus, Cochrane Library, and Virtual Health Library databases through December 2021 was then performed. Subsequently, the primary and secondary outcomes were used in the meta-analysis in RStudio® software. Seventy-two studies were included with 6,011 SCD patients confirmed to have SARS-CoV-2 infection between mid-2020 and early 2022. The mean age of patients was 27 years. During this period, 218 deaths caused by COVID-19 were reported in the studied population, corresponding to an overall case fatality rate of 3%. In addition, 10% of patients with SCD were admitted to the ICU after complications caused by COVID-19, and 4% of them required invasive ventilatory support. In conclusion, the high fatality rate, intensive care unit admission and need for mechanical ventilation due to COVID-19 in young patients with SCD indicate that this population is at high risk for severe disease progression.
Keywords: Coronavirus disease 2019 (COVID-19); case fatality rate; intensive care unit; mechanical ventilation; sickle cell disease.
. 2023 Jun 16;1-12.
doi: 10.1080/03630269.2023.2219847. Online ahead of print. Case Fatality Rate and Severity of COVID-19 among Patients with Sickle Cell Disease: A Systematic Review and Meta-Analysis
Tarcísio Silva Borborema[SUP] 1 2 [/SUP], Julio Cesar Moreira Brito[SUP] 3 [/SUP], Edleusa Marques Lima Batista[SUP] 4 [/SUP], Rodrigo Siqueira Batista[SUP] 1 5 [/SUP]
Affiliations
- PMID: 37325879
- DOI: 10.1080/03630269.2023.2219847
The sickle cell disease (SCD) population has been considered particularly vulnerable to viral pandemics since the emergence of H1N1 in 2009. In this sense, the advance of the COVID-19 pandemic from 2020 has brought this group of patients to the center of concern. However, scientific knowledge about the susceptibility of patients with SCD to a severe COVID-19 pandemic is still insufficient, and efforts to establish a general profile of the disease in these patients, remain inadequate. The present study, therefore, sought to characterize the case fatality rate and severity of COVID-19 in patients with SCD throughout the world. A systematic review of Pubmed/MEDLINE, Scopus, Cochrane Library, and Virtual Health Library databases through December 2021 was then performed. Subsequently, the primary and secondary outcomes were used in the meta-analysis in RStudio® software. Seventy-two studies were included with 6,011 SCD patients confirmed to have SARS-CoV-2 infection between mid-2020 and early 2022. The mean age of patients was 27 years. During this period, 218 deaths caused by COVID-19 were reported in the studied population, corresponding to an overall case fatality rate of 3%. In addition, 10% of patients with SCD were admitted to the ICU after complications caused by COVID-19, and 4% of them required invasive ventilatory support. In conclusion, the high fatality rate, intensive care unit admission and need for mechanical ventilation due to COVID-19 in young patients with SCD indicate that this population is at high risk for severe disease progression.
Keywords: Coronavirus disease 2019 (COVID-19); case fatality rate; intensive care unit; mechanical ventilation; sickle cell disease.