tetano
Editor, Senior Moderator
Hematology
. 2021 Dec;26(1):656-662.
doi: 10.1080/16078454.2021.1968648.
Association of coagulation disturbances with severity of COVID-19: a longitudinal study
Huimin Lu[SUP] 1 [/SUP], Ming Chen[SUP] 1 [/SUP], Shaoqiu Tang[SUP] 2 [/SUP], Wenkui Yu[SUP] 1 [/SUP]
Affiliations
Abstract
Objectives: Coagulation dysfunction is an evident factor in the clinical diagnosis and treatment of patients with coronavirus disease 2019 (COVID-19), appearing even in COVID-19 patients with normal inflammation indices. Therefore, this study aimed to analyze the characteristics of coagulation function indices in COVID-19 patients to investigate possible mechanisms through the comparison of non-severe and severe COVID-19 patients.
Methods: We included 143 patients whose clinical characteristics, coagulation function, and other indices such as inflammatory factors were collected and compared based on disease severity.
Results: Activated partial thromboplastin time (APTT), D-dimer, and fibrinogen levels were evidently higher in the severe group than in the non-severe group. Among non-severe COVID-19 patients, the aforementioned indicators depicted increasing trends, but the fibrinogen level alone was higher than normal. However, in severe COVID-19 patients, values of all three indices were higher than normal. In severe COVID-19 patients, fibrinogen and D-dimer were correlated with several inflammation indices during the early stage of the disease. However, no correlation between fibrinogen and inflammatory factors was observed in non-severe COVID-19 patients at any time point.
Discussion: Results revealed that the hypercoagulability tendency of severe COVID-19 patients was more evident. The relationship between coagulation function and inflammatory factors showed that changes in coagulation function in severe COVID-19 patients may be related to abnormal increase in inflammatory factors at an early stage; however, in non-severe COVID-19 patients, there might be other factors leading to abnormal coagulation.
Conclusion: Inflammatory factors were not the only cause of abnormal coagulation function in COVID-19 patients.
Keywords: COVID-19; D-dimer; activated partial thromboplastin time; coagulation; cytokines; disseminated intravascular coagulation; fibrinogen; procalcitonin.
. 2021 Dec;26(1):656-662.
doi: 10.1080/16078454.2021.1968648.
Association of coagulation disturbances with severity of COVID-19: a longitudinal study
Huimin Lu[SUP] 1 [/SUP], Ming Chen[SUP] 1 [/SUP], Shaoqiu Tang[SUP] 2 [/SUP], Wenkui Yu[SUP] 1 [/SUP]
Affiliations
- PMID: 34493174
- DOI: 10.1080/16078454.2021.1968648
Abstract
Objectives: Coagulation dysfunction is an evident factor in the clinical diagnosis and treatment of patients with coronavirus disease 2019 (COVID-19), appearing even in COVID-19 patients with normal inflammation indices. Therefore, this study aimed to analyze the characteristics of coagulation function indices in COVID-19 patients to investigate possible mechanisms through the comparison of non-severe and severe COVID-19 patients.
Methods: We included 143 patients whose clinical characteristics, coagulation function, and other indices such as inflammatory factors were collected and compared based on disease severity.
Results: Activated partial thromboplastin time (APTT), D-dimer, and fibrinogen levels were evidently higher in the severe group than in the non-severe group. Among non-severe COVID-19 patients, the aforementioned indicators depicted increasing trends, but the fibrinogen level alone was higher than normal. However, in severe COVID-19 patients, values of all three indices were higher than normal. In severe COVID-19 patients, fibrinogen and D-dimer were correlated with several inflammation indices during the early stage of the disease. However, no correlation between fibrinogen and inflammatory factors was observed in non-severe COVID-19 patients at any time point.
Discussion: Results revealed that the hypercoagulability tendency of severe COVID-19 patients was more evident. The relationship between coagulation function and inflammatory factors showed that changes in coagulation function in severe COVID-19 patients may be related to abnormal increase in inflammatory factors at an early stage; however, in non-severe COVID-19 patients, there might be other factors leading to abnormal coagulation.
Conclusion: Inflammatory factors were not the only cause of abnormal coagulation function in COVID-19 patients.
Keywords: COVID-19; D-dimer; activated partial thromboplastin time; coagulation; cytokines; disseminated intravascular coagulation; fibrinogen; procalcitonin.