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Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets

tetano

tetano

Editor, Senior Moderator
J Virol. 2015 Dec 30. pii: JVI.02481-15. [Epub ahead of print]
[h=1]Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets.[/h] Nachbagauer R[SUP]1[/SUP], Miller MS[SUP]2[/SUP], Hai R[SUP]3[/SUP], Ryder AB[SUP]4[/SUP], Rose JK[SUP]4[/SUP], Palese P[SUP]5[/SUP], Garc?a-Sastre A[SUP]6[/SUP], Krammer F[SUP]7[/SUP], Albrecht RA[SUP]8[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] We assessed in ferrets whether influenza virus hemagglutinin stalk-based immunity provided protection against aerosol-transmitted H1N1 infection. Immunization of ferrets with a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were co-housed with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers, delayed or no virus replication at all following natural exposure to influenza virus.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.


PMID: 26719251 [PubMed - as supplied by publisher]
 
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