tetano
Editor, Senior Moderator
Hum Vaccin Immunother. 2016 Dec 1:0. [Epub ahead of print]
[h=1]Hemagglutination inhibiting antibody persistence 1 year after of influenza vaccination in Korean children and adolescents.[/h] Kang EK[SUP]1[/SUP], Eun BW[SUP]2[/SUP], Kim NH[SUP]3[/SUP], Kim YK[SUP]4[/SUP], Lim JS[SUP]5[/SUP], Kim DH[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] This study aimed to assess the one-year immunogenicity of influenza vaccines and the association between immunogenicity at one month and further influenza infections in children aged 6 months to 18 years. Serum hemagglutination inhibition (HI) antibody titers and GMTs were determined for the recommended influenza strains 0, 1, 6, and 12 months post-vaccination. The serological evidence of influenza infections were defined as the increase of HI titer (HI ≥1:40 and 4-fold rise). The seroprotection rates for strains A(H1N1), A(H3N2), and B were 91.2%, 87.6%, and 87.6%, respectively, at 1 month (n = 174). These rates were 76.5%, 64.7%, and 54.6%, respectively, at 12 months. The seroprotection rates and GMTs for influenza A(H1N1) and A(H3N2) were higher at 12 months than at 0 month (p<0.05) but not for B. There were 39 subjects (42 cases) of serological influenza infections. Subjects with seroprotection at 1 month post-vaccination had showed fewer serologic A(H1N1) (10.1 vs 54.5%) and A(H3N2) (7.2 vs 38.1%) infections than the ones with HI titer <1:40 during follow-up (P<0.01). In conclusion, influenza vaccines used during the 2008-09 season induced adequate 1-year immunogenicity for A(H1N1) and A(H3N2). The immunogenicity at one month after vaccination influenced further serological influenza infections.
[h=4]KEYWORDS:[/h] 1-year immunogenicity; Influenza vaccine; children; hemagglutination inhibition; seroprotection rate
PMID: 27905835 DOI: 10.1080/21645515.2016.1259044
[PubMed - as supplied by publisher]
[h=1]Hemagglutination inhibiting antibody persistence 1 year after of influenza vaccination in Korean children and adolescents.[/h] Kang EK[SUP]1[/SUP], Eun BW[SUP]2[/SUP], Kim NH[SUP]3[/SUP], Kim YK[SUP]4[/SUP], Lim JS[SUP]5[/SUP], Kim DH[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] This study aimed to assess the one-year immunogenicity of influenza vaccines and the association between immunogenicity at one month and further influenza infections in children aged 6 months to 18 years. Serum hemagglutination inhibition (HI) antibody titers and GMTs were determined for the recommended influenza strains 0, 1, 6, and 12 months post-vaccination. The serological evidence of influenza infections were defined as the increase of HI titer (HI ≥1:40 and 4-fold rise). The seroprotection rates for strains A(H1N1), A(H3N2), and B were 91.2%, 87.6%, and 87.6%, respectively, at 1 month (n = 174). These rates were 76.5%, 64.7%, and 54.6%, respectively, at 12 months. The seroprotection rates and GMTs for influenza A(H1N1) and A(H3N2) were higher at 12 months than at 0 month (p<0.05) but not for B. There were 39 subjects (42 cases) of serological influenza infections. Subjects with seroprotection at 1 month post-vaccination had showed fewer serologic A(H1N1) (10.1 vs 54.5%) and A(H3N2) (7.2 vs 38.1%) infections than the ones with HI titer <1:40 during follow-up (P<0.01). In conclusion, influenza vaccines used during the 2008-09 season induced adequate 1-year immunogenicity for A(H1N1) and A(H3N2). The immunogenicity at one month after vaccination influenced further serological influenza infections.
[h=4]KEYWORDS:[/h] 1-year immunogenicity; Influenza vaccine; children; hemagglutination inhibition; seroprotection rate
PMID: 27905835 DOI: 10.1080/21645515.2016.1259044
[PubMed - as supplied by publisher]