tetano
Editor, Senior Moderator
Heliyon
. 2021 Jan 9;7(1):e05951.
doi: 10.1016/j.heliyon.2021.e05951. eCollection 2021 Jan.
Understanding the implications of SARS-CoV-2 re-infections on immune response milieu, laboratory tests and control measures against COVID-19
Jelili Olaide Mustapha[SUP] 1 [/SUP], Idris Nasir Abdullahi[SUP] 2 [/SUP], Odunayo O R Ajagbe[SUP] 3 [/SUP], Anthony Uchenna Emeribe[SUP] 4 [/SUP], Samuel Ayobami Fasogbon[SUP] 5 [/SUP], Solomon Oloche Onoja[SUP] 6 [/SUP], Charles Egede Ugwu[SUP] 7 [/SUP], Chikodi Modesta Umeozuru[SUP] 8 [/SUP], Folake Olubunmi Ajayi[SUP] 8 [/SUP], Wudi Natasha Tanko[SUP] 8 [/SUP], Pius Omoruyi Omosigho[SUP] 9 [/SUP], Abdulmumuni Samuel Aliyu[SUP] 10 [/SUP], Halima Ali Shuwa[SUP] 11 [/SUP], Justin Onyebuchi Nwofe[SUP] 7 [/SUP], Amos Dangana[SUP] 12 [/SUP], Ovye Alaba[SUP] 12 [/SUP], Peter Elisha Ghamba[SUP] 13 [/SUP], Yakubu Ibrahim[SUP] 2 [/SUP], Dorcas Aliyu[SUP] 4 [/SUP], Olawale Sunday Animasaun[SUP] 8 [/SUP], Nkechi Blessing Ugboaja[SUP] 14 [/SUP], Mala Alhaji Baba Mallam[SUP] 15 [/SUP], Sharafudeen Dahiru Abubakar[SUP] 2 [/SUP], Maijidda Saidu Aminu[SUP] 15 [/SUP], Hadiza Yahaya[SUP] 15 [/SUP], Silifat Oyewusi[SUP] 15 [/SUP]
Affiliations
Abstract
Several months after the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), cases of re-infection after recovery were reported. The extent and duration of protective immunity after SARS-CoV-2 infection is not fully understood. As such, the possibility of re-infection with SARS-CoV-2. Furthermore, cases of re-infection were mainly due to different variants or mutant SARS-CoV-2. Following the fast and pandemic-scale spread of COVID-19, mutations in SARS-CoV-2 have raised new diagnostic challenges which include the redesign of the oligonucleotide sequences used in RT-PCR assays to avoid potential primer-sample mismatches, and decrease sensitivities. Since the initial wave of the pandemic, some regions had experienced fresh outbreaks, predisposing people to be susceptible to SARS-CoV-2 re-infection. Hence, this article sought to offer detailed biology of SARS-CoV-2 re-infections and their implications on immune response milieu, diagnostic laboratory tests and control measures against COVID-19.
Keywords: COVID-19; Diagnostic challenges; Immune evasion; Infection control; SARS-CoV-2 re-infection.
. 2021 Jan 9;7(1):e05951.
doi: 10.1016/j.heliyon.2021.e05951. eCollection 2021 Jan.
Understanding the implications of SARS-CoV-2 re-infections on immune response milieu, laboratory tests and control measures against COVID-19
Jelili Olaide Mustapha[SUP] 1 [/SUP], Idris Nasir Abdullahi[SUP] 2 [/SUP], Odunayo O R Ajagbe[SUP] 3 [/SUP], Anthony Uchenna Emeribe[SUP] 4 [/SUP], Samuel Ayobami Fasogbon[SUP] 5 [/SUP], Solomon Oloche Onoja[SUP] 6 [/SUP], Charles Egede Ugwu[SUP] 7 [/SUP], Chikodi Modesta Umeozuru[SUP] 8 [/SUP], Folake Olubunmi Ajayi[SUP] 8 [/SUP], Wudi Natasha Tanko[SUP] 8 [/SUP], Pius Omoruyi Omosigho[SUP] 9 [/SUP], Abdulmumuni Samuel Aliyu[SUP] 10 [/SUP], Halima Ali Shuwa[SUP] 11 [/SUP], Justin Onyebuchi Nwofe[SUP] 7 [/SUP], Amos Dangana[SUP] 12 [/SUP], Ovye Alaba[SUP] 12 [/SUP], Peter Elisha Ghamba[SUP] 13 [/SUP], Yakubu Ibrahim[SUP] 2 [/SUP], Dorcas Aliyu[SUP] 4 [/SUP], Olawale Sunday Animasaun[SUP] 8 [/SUP], Nkechi Blessing Ugboaja[SUP] 14 [/SUP], Mala Alhaji Baba Mallam[SUP] 15 [/SUP], Sharafudeen Dahiru Abubakar[SUP] 2 [/SUP], Maijidda Saidu Aminu[SUP] 15 [/SUP], Hadiza Yahaya[SUP] 15 [/SUP], Silifat Oyewusi[SUP] 15 [/SUP]
Affiliations
- PMID: 33490695
- PMCID: PMC7810769
- DOI: 10.1016/j.heliyon.2021.e05951
Abstract
Several months after the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), cases of re-infection after recovery were reported. The extent and duration of protective immunity after SARS-CoV-2 infection is not fully understood. As such, the possibility of re-infection with SARS-CoV-2. Furthermore, cases of re-infection were mainly due to different variants or mutant SARS-CoV-2. Following the fast and pandemic-scale spread of COVID-19, mutations in SARS-CoV-2 have raised new diagnostic challenges which include the redesign of the oligonucleotide sequences used in RT-PCR assays to avoid potential primer-sample mismatches, and decrease sensitivities. Since the initial wave of the pandemic, some regions had experienced fresh outbreaks, predisposing people to be susceptible to SARS-CoV-2 re-infection. Hence, this article sought to offer detailed biology of SARS-CoV-2 re-infections and their implications on immune response milieu, diagnostic laboratory tests and control measures against COVID-19.
Keywords: COVID-19; Diagnostic challenges; Immune evasion; Infection control; SARS-CoV-2 re-infection.