tetano
Editor, Senior Moderator
Heliyon
. 2024 Aug 11;10(16):e35988.
doi: 10.1016/j.heliyon.2024.e35988. eCollection 2024 Aug 30. Repurposing existing drugs for the treatment ofCOVID-19/SARS-CoV-2: A review of pharmacological effects and mechanism of action
Yutong Liang[SUP] 1 [/SUP], Xiaoxiao Quan[SUP] 1 2 [/SUP], Ruolan Gu[SUP] 1 [/SUP], Zhiyun Meng[SUP] 1 [/SUP], Hui Gan[SUP] 1 [/SUP], Zhuona Wu[SUP] 1 [/SUP], Yunbo Sun[SUP] 1 [/SUP], Huajie Pan[SUP] 3 [/SUP], Peng Han[SUP] 1 [/SUP], Shuchen Liu[SUP] 1 [/SUP], Guifang Dou[SUP] 1 [/SUP]
Affiliations
Following the coronavirus disease-2019 outbreak caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), there is an ongoing need to seek drugs that target COVID-19. First off, novel drugs have a long development cycle, high investment cost, and are high risk. Second, novel drugs must be evaluated for activity, efficacy, safety, and metabolic performance, contributing to the development cycle, investment cost, and risk. We searched the Cochrane COVID-19 Study Register (including PubMed, Embase, CENTRAL, ClinicalTrials.gov, WHO ICTRP, and medRxiv), Web of Science (Science Citation Index, Emerging Citation Index), and WHO COVID-19 Coronaviral Disease Global Literature to identify completed and ongoing studies as of February 20, 2024. We evaluated the pharmacological effects, in vivo and in vitro data of the 16 candidates in the paper. The difficulty of studying these candidates in clinical trials involving COVID-19 patients, dosage of repurposed drugs, etc. is discussed in detail. Ultimately, Metformin is more suitable for prophylactic administration or mildly ill patients; the combination of Oseltamivir, Tamoxifen, and Dexamethasone is suitable for moderately and severely ill patients; and more clinical trials are needed for Azvudine, Ribavirin, Colchicine, and Cepharanthine to demonstrate efficacy.
Keywords: Clinical trials; Drug repositioning; Pharmacological effects; Severe acute respiratory syndrome coronavirus type 2.
. 2024 Aug 11;10(16):e35988.
doi: 10.1016/j.heliyon.2024.e35988. eCollection 2024 Aug 30. Repurposing existing drugs for the treatment ofCOVID-19/SARS-CoV-2: A review of pharmacological effects and mechanism of action
Yutong Liang[SUP] 1 [/SUP], Xiaoxiao Quan[SUP] 1 2 [/SUP], Ruolan Gu[SUP] 1 [/SUP], Zhiyun Meng[SUP] 1 [/SUP], Hui Gan[SUP] 1 [/SUP], Zhuona Wu[SUP] 1 [/SUP], Yunbo Sun[SUP] 1 [/SUP], Huajie Pan[SUP] 3 [/SUP], Peng Han[SUP] 1 [/SUP], Shuchen Liu[SUP] 1 [/SUP], Guifang Dou[SUP] 1 [/SUP]
Affiliations
- PMID: 39247343
- PMCID: PMC11379597
- DOI: 10.1016/j.heliyon.2024.e35988
Following the coronavirus disease-2019 outbreak caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), there is an ongoing need to seek drugs that target COVID-19. First off, novel drugs have a long development cycle, high investment cost, and are high risk. Second, novel drugs must be evaluated for activity, efficacy, safety, and metabolic performance, contributing to the development cycle, investment cost, and risk. We searched the Cochrane COVID-19 Study Register (including PubMed, Embase, CENTRAL, ClinicalTrials.gov, WHO ICTRP, and medRxiv), Web of Science (Science Citation Index, Emerging Citation Index), and WHO COVID-19 Coronaviral Disease Global Literature to identify completed and ongoing studies as of February 20, 2024. We evaluated the pharmacological effects, in vivo and in vitro data of the 16 candidates in the paper. The difficulty of studying these candidates in clinical trials involving COVID-19 patients, dosage of repurposed drugs, etc. is discussed in detail. Ultimately, Metformin is more suitable for prophylactic administration or mildly ill patients; the combination of Oseltamivir, Tamoxifen, and Dexamethasone is suitable for moderately and severely ill patients; and more clinical trials are needed for Azvudine, Ribavirin, Colchicine, and Cepharanthine to demonstrate efficacy.
Keywords: Clinical trials; Drug repositioning; Pharmacological effects; Severe acute respiratory syndrome coronavirus type 2.