tetano
Editor, Senior Moderator
Heliyon
. 2024 Jan 14;10(2):e24508.
doi: 10.1016/j.heliyon.2024.e24508. eCollection 2024 Jan 30. Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level
Jöran Lücke[SUP] 1 2 3 [/SUP], Marius Böttcher[SUP] 1 2 4 [/SUP], Mikolaj Nawrocki[SUP] 1 2 4 [/SUP], Nicholas Meins[SUP] 1 2 [/SUP], Josa Schnell[SUP] 1 2 [/SUP], Fabian Heinrich[SUP] 5 6 [/SUP], Franziska Bertram[SUP] 1 2 6 [/SUP], Morsal Sabihi[SUP] 1 2 [/SUP], Philipp Seeger[SUP] 3 [/SUP], Marie Pfaff[SUP] 3 [/SUP], Sara Notz[SUP] 3 [/SUP], Tom Blankenburg[SUP] 1 2 [/SUP], Tao Zhang[SUP] 1 2 [/SUP], Jan Kempski[SUP] 1 2 4 7 [/SUP], Matthias Reeh[SUP] 3 [/SUP], Stefan Wolter[SUP] 3 [/SUP], Oliver Mann[SUP] 3 [/SUP], Marc Lütgehetmann[SUP] 6 [/SUP], Thilo Hackert[SUP] 3 [/SUP], Jakob R Izbicki[SUP] 3 [/SUP], Anna Duprée[SUP] 3 [/SUP], Samuel Huber[SUP] 1 2 4 [/SUP], Benjamin Ondruschka[SUP] 5 [/SUP], Anastasios D Giannou[SUP] 1 2 3 [/SUP]
Affiliations
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is responsible for eliciting Coronavirus disease 2019 (COVID-19) still challenges healthcare services worldwide. While many patients only suffer from mild symptoms, patients with some pre-existing medical conditions are at a higher risk for a detrimental course of disease. However, the underlying mechanisms determining disease course are only partially understood. One key factor influencing disease severity is described to be immune-mediated. In this report, we describe a post-mortem analysis of 45 individuals who died from SARS-CoV-2 infection. We could show that although sociodemographic factors and premedical conditions such as obesity and diabetes mellitus reduced survival time in our cohort, they were not associated with changes in the expression of immune-related signature genes at the RNA level in the blood, the gut, or the liver between these different groups. Our data indicate that obesity and diabetes mellitus influence SARS-CoV-2-related mortality, without influencing the extrapulmonary gene expression of immunity-related signature genes at the RNA level.
. 2024 Jan 14;10(2):e24508.
doi: 10.1016/j.heliyon.2024.e24508. eCollection 2024 Jan 30. Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level
Jöran Lücke[SUP] 1 2 3 [/SUP], Marius Böttcher[SUP] 1 2 4 [/SUP], Mikolaj Nawrocki[SUP] 1 2 4 [/SUP], Nicholas Meins[SUP] 1 2 [/SUP], Josa Schnell[SUP] 1 2 [/SUP], Fabian Heinrich[SUP] 5 6 [/SUP], Franziska Bertram[SUP] 1 2 6 [/SUP], Morsal Sabihi[SUP] 1 2 [/SUP], Philipp Seeger[SUP] 3 [/SUP], Marie Pfaff[SUP] 3 [/SUP], Sara Notz[SUP] 3 [/SUP], Tom Blankenburg[SUP] 1 2 [/SUP], Tao Zhang[SUP] 1 2 [/SUP], Jan Kempski[SUP] 1 2 4 7 [/SUP], Matthias Reeh[SUP] 3 [/SUP], Stefan Wolter[SUP] 3 [/SUP], Oliver Mann[SUP] 3 [/SUP], Marc Lütgehetmann[SUP] 6 [/SUP], Thilo Hackert[SUP] 3 [/SUP], Jakob R Izbicki[SUP] 3 [/SUP], Anna Duprée[SUP] 3 [/SUP], Samuel Huber[SUP] 1 2 4 [/SUP], Benjamin Ondruschka[SUP] 5 [/SUP], Anastasios D Giannou[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 38298642
- PMCID: PMC10828091
- DOI: 10.1016/j.heliyon.2024.e24508
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is responsible for eliciting Coronavirus disease 2019 (COVID-19) still challenges healthcare services worldwide. While many patients only suffer from mild symptoms, patients with some pre-existing medical conditions are at a higher risk for a detrimental course of disease. However, the underlying mechanisms determining disease course are only partially understood. One key factor influencing disease severity is described to be immune-mediated. In this report, we describe a post-mortem analysis of 45 individuals who died from SARS-CoV-2 infection. We could show that although sociodemographic factors and premedical conditions such as obesity and diabetes mellitus reduced survival time in our cohort, they were not associated with changes in the expression of immune-related signature genes at the RNA level in the blood, the gut, or the liver between these different groups. Our data indicate that obesity and diabetes mellitus influence SARS-CoV-2-related mortality, without influencing the extrapulmonary gene expression of immunity-related signature genes at the RNA level.
