tetano
Editor, Senior Moderator
Heliyon
. 2023 Dec 3;9(12):e23306.
doi: 10.1016/j.heliyon.2023.e23306. eCollection 2023 Dec. Neutrophil extracellular traps in influenza infection
Alireza Zafarani[SUP] 1 [/SUP], Mohammad Hossein Razizadeh[SUP] 2 3 [/SUP], Atousa Haghi[SUP] 4 [/SUP]
Affiliations
Despite recent progress in developing novel therapeutic approaches and vaccines, influenza is still considered a global health threat, with about half a million mortality worldwide. This disease is caused by Influenza viruses, which are known for their rapid evolution due to different genetical mechanisms that help them develop new strains with the ability to evade therapies and immunization. Neutrophils are one of the first immune effectors that act against pathogens. They use multiple mechanisms, including phagocytosis, releasing the reactive oxygen species, degranulation, and the production of neutrophil extracellular traps. Neutrophil extracellular traps are used to ensnare pathogens; however, their dysregulation is attributed to inflammatory and infectious diseases. Here, we discuss the effects of these extracellular traps in the clinical course of influenza infection and their ability to be a potential target in treating influenza infection.
Keywords: Influenza; Neutrophil; Neutrophil extracellular traps.
. 2023 Dec 3;9(12):e23306.
doi: 10.1016/j.heliyon.2023.e23306. eCollection 2023 Dec. Neutrophil extracellular traps in influenza infection
Alireza Zafarani[SUP] 1 [/SUP], Mohammad Hossein Razizadeh[SUP] 2 3 [/SUP], Atousa Haghi[SUP] 4 [/SUP]
Affiliations
- PMID: 38144312
- PMCID: PMC10746519
- DOI: 10.1016/j.heliyon.2023.e23306
Despite recent progress in developing novel therapeutic approaches and vaccines, influenza is still considered a global health threat, with about half a million mortality worldwide. This disease is caused by Influenza viruses, which are known for their rapid evolution due to different genetical mechanisms that help them develop new strains with the ability to evade therapies and immunization. Neutrophils are one of the first immune effectors that act against pathogens. They use multiple mechanisms, including phagocytosis, releasing the reactive oxygen species, degranulation, and the production of neutrophil extracellular traps. Neutrophil extracellular traps are used to ensnare pathogens; however, their dysregulation is attributed to inflammatory and infectious diseases. Here, we discuss the effects of these extracellular traps in the clinical course of influenza infection and their ability to be a potential target in treating influenza infection.
Keywords: Influenza; Neutrophil; Neutrophil extracellular traps.