tetano
Editor, Senior Moderator
Heliyon
. 2021 Apr;7(4):e06836.
doi: 10.1016/j.heliyon.2021.e06836. Epub 2021 Apr 17.
Landscape of humoral immune responses against SARS-CoV-2 in patients with COVID-19 disease and the value of antibody testing
Sundarasamy Mahalingam[SUP] 1 [/SUP], John Peter[SUP] 1 [/SUP], Ziyang Xu[SUP] 2 [/SUP], Devivasha Bordoloi[SUP] 2 [/SUP], Michelle Ho[SUP] 2 [/SUP], Vaniambadi S Kalyanaraman[SUP] 3 [/SUP], Alagarsamy Srinivasan[SUP] 4 [/SUP], Kar Muthumani[SUP] 2 [/SUP]
Affiliations
Abstract
A new pandemic is ongoing in several parts of the world. The agent responsible is the newly emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The symptoms associated with this virus are known as the coronavirus disease-2019 (COVID-19). In this review, we summarize the published data on virus specific antibodies in hospitalized patients with COVID-19 disease, patients recovered from the disease and the individuals who are asymptomatic with SARS-CoV-2 infections. The review highlights the following: i) an adjunct role of antibody tests in the diagnosis of COVID-19 in combination with RT-PCR; ii) status of antibodies from COVID-19 convalescent patients to select donors for plasma therapy; iii) the potential confounding effects of other coronaviruses, measles, mumps and rubella in antibody testing due to homology of certain viral genes; and iv) the role of antibody testing for conducting surveillance in populations, incidence estimation, contact tracing and epidemiologic studies.
Keywords: Antibody tests; Diagnosis of COVID-19; RT-PCR; Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
. 2021 Apr;7(4):e06836.
doi: 10.1016/j.heliyon.2021.e06836. Epub 2021 Apr 17.
Landscape of humoral immune responses against SARS-CoV-2 in patients with COVID-19 disease and the value of antibody testing
Sundarasamy Mahalingam[SUP] 1 [/SUP], John Peter[SUP] 1 [/SUP], Ziyang Xu[SUP] 2 [/SUP], Devivasha Bordoloi[SUP] 2 [/SUP], Michelle Ho[SUP] 2 [/SUP], Vaniambadi S Kalyanaraman[SUP] 3 [/SUP], Alagarsamy Srinivasan[SUP] 4 [/SUP], Kar Muthumani[SUP] 2 [/SUP]
Affiliations
- PMID: 33898857
- PMCID: PMC8052472
- DOI: 10.1016/j.heliyon.2021.e06836
Abstract
A new pandemic is ongoing in several parts of the world. The agent responsible is the newly emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The symptoms associated with this virus are known as the coronavirus disease-2019 (COVID-19). In this review, we summarize the published data on virus specific antibodies in hospitalized patients with COVID-19 disease, patients recovered from the disease and the individuals who are asymptomatic with SARS-CoV-2 infections. The review highlights the following: i) an adjunct role of antibody tests in the diagnosis of COVID-19 in combination with RT-PCR; ii) status of antibodies from COVID-19 convalescent patients to select donors for plasma therapy; iii) the potential confounding effects of other coronaviruses, measles, mumps and rubella in antibody testing due to homology of certain viral genes; and iv) the role of antibody testing for conducting surveillance in populations, incidence estimation, contact tracing and epidemiologic studies.
Keywords: Antibody tests; Diagnosis of COVID-19; RT-PCR; Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).