tetano
Editor, Senior Moderator
Heliyon
. 2021 Mar;7(3):e06393.
doi: 10.1016/j.heliyon.2021.e06393. Epub 2021 Mar 2.
Impact of SARS-CoV-2 on the clinical outcomes and placental pathology of pregnant women and their infants: A systematic review
Irina Oltean[SUP] 1 [/SUP], Jason Tran[SUP] 2 [/SUP], Sarah Lawrence[SUP] 1 2 3 [/SUP], Brittany Ann Ruschkowski[SUP] 2 [/SUP], Na Zeng[SUP] 2 [/SUP], Cameron Bardwell[SUP] 2 [/SUP], Youssef Nasr[SUP] 2 [/SUP], Joseph de Nanassy[SUP] 1 2 4 [/SUP], Dina El Demellawy[SUP] 1 2 4 [/SUP]
Affiliations
Abstract
Pregnant women are susceptible to viral infections due to physiological changes such as cell-mediated immunity. No severe adverse pregnancy or neonatal outcomes have been consistently reported in 2019 novel coronavirus disease (COVID-19) positive pregnancy cases. There are controversies around the role of COVID-19 in pregnancy. A systematic review was conducted to examine clinical maternal and neonatal clinical outcomes. Studies were included if they reported SARS-CoV-2 infection among pregnant women and/or COVID-19 positive neonates as validated by positive antibody testing or viral testing using polymerase chain reaction. Case series, case reports, case-control studies, and comparative studies were included. Eight hundred and thirty-seven records were identified, resulting in 525 records for level I screening. Forty-one were included after full-text review. Results suggest elevated rates of intensive care unit (ICU) admission, gestational diabetes, preeclampsia, C-sections, pre-term birth, and C-reactive protein (CRP) in comparison to pregnant women without SARS-CoV-2. Careful monitoring of pregnancies with SARS-CoV-2 is recommended.
Keywords: COVID-19; Neonates; Placenta diseases; Placental pathology; Pregnant women; SARS-CoV-2.
. 2021 Mar;7(3):e06393.
doi: 10.1016/j.heliyon.2021.e06393. Epub 2021 Mar 2.
Impact of SARS-CoV-2 on the clinical outcomes and placental pathology of pregnant women and their infants: A systematic review
Irina Oltean[SUP] 1 [/SUP], Jason Tran[SUP] 2 [/SUP], Sarah Lawrence[SUP] 1 2 3 [/SUP], Brittany Ann Ruschkowski[SUP] 2 [/SUP], Na Zeng[SUP] 2 [/SUP], Cameron Bardwell[SUP] 2 [/SUP], Youssef Nasr[SUP] 2 [/SUP], Joseph de Nanassy[SUP] 1 2 4 [/SUP], Dina El Demellawy[SUP] 1 2 4 [/SUP]
Affiliations
- PMID: 33688585
- PMCID: PMC7923950
- DOI: 10.1016/j.heliyon.2021.e06393
Abstract
Pregnant women are susceptible to viral infections due to physiological changes such as cell-mediated immunity. No severe adverse pregnancy or neonatal outcomes have been consistently reported in 2019 novel coronavirus disease (COVID-19) positive pregnancy cases. There are controversies around the role of COVID-19 in pregnancy. A systematic review was conducted to examine clinical maternal and neonatal clinical outcomes. Studies were included if they reported SARS-CoV-2 infection among pregnant women and/or COVID-19 positive neonates as validated by positive antibody testing or viral testing using polymerase chain reaction. Case series, case reports, case-control studies, and comparative studies were included. Eight hundred and thirty-seven records were identified, resulting in 525 records for level I screening. Forty-one were included after full-text review. Results suggest elevated rates of intensive care unit (ICU) admission, gestational diabetes, preeclampsia, C-sections, pre-term birth, and C-reactive protein (CRP) in comparison to pregnant women without SARS-CoV-2. Careful monitoring of pregnancies with SARS-CoV-2 is recommended.
Keywords: COVID-19; Neonates; Placenta diseases; Placental pathology; Pregnant women; SARS-CoV-2.