tetano
Editor, Senior Moderator
Heart Vessels
. 2022 Sep 28.
doi: 10.1007/s00380-022-02180-2. Online ahead of print.
Impaired left ventricular deformation and ventricular-arterial coupling in post-COVID-19: association with autonomic dysregulation
Evangelos Oikonomou[SUP] #[/SUP][SUP] 1 2 [/SUP], Stamatios Lampsas[SUP] #[/SUP][SUP] 3 [/SUP], Panagiotis Theofilis[SUP] 4 [/SUP], Nektarios Souvaliotis[SUP] 3 [/SUP], George Aggelos Papamikroulis[SUP] 3 [/SUP], Ourania Katsarou[SUP] 3 [/SUP], Konstantinos Kalogeras[SUP] 3 4 [/SUP], Panteleimon Pantelidis[SUP] 3 [/SUP], Theodore G Papaioannou[SUP] 3 [/SUP], Aikaterini Tsatsaragkou[SUP] 3 [/SUP], Georgios Marinos[SUP] 4 [/SUP], Gerasimos Siasos[SUP] 3 5 [/SUP], Dimitris Tousoulis[SUP] 4 [/SUP], Manolis Vavuranakis[SUP] 3 4 [/SUP]
Affiliations
Abstract
Coronavirus disease-19 (COVID-19) has extended implications namely the long COVID-19 syndrome. We assessed over-time changes in left ventricular (LV) function, aortic stiffness, autonomic function, and ventricular-arterial coupling (VAC) in post-COVID-19 patients. We followed 34 post-COVID-19 subjects, up to 6 months post-hospital discharge. Subjects without COVID-19 served as control. We evaluated LV global longitudinal strain (LV-GLS), arterial stiffness [carotid-femoral pulse wave velocity (cf-PWV)], and heart rate variability -standard deviation of normal RR intervals (SDNN). VAC was estimated as the ratio of cf-PWV to LV-GLS. Post-COVID-19 individuals (1-month post-hospital discharge) presented with impaired LV-GLS [-18.4%(3.1) vs. -22.0%(2.7), P < 0.001], cf-PWV [12.1 m/s (3.2) vs. 9.6 m/s (1.9), P < 0.001], SDNN [111.3 ms (22.6) vs. 147.2 ms (14.0), P < 0.001], and VAC [-0.68 (0.22) vs. -0.44 (0.10), P < 0.001] compared to control. LV-GLS, SDNN, and VAC improved at the 6-month follow-up however they did not reach control levels. In post-COVID-19 subjects, SDNN and VAC were correlated at the 1-month (R = 0.499, P = 0.003) and 6-month (R = 0.372, P = 0.04) follow-up. Long COVID-19 syndrome was associated with impaired LV-GLS, SDNN, and VAC. Post-COVID-19 subjects presented with autonomic dysregulation associated with aortic stiffness, ventricular-arterial impairment, and LV dysfunction, even 6-months post-hospital discharge. These abnormalities may be related to the presence of long COVID-19 syndrome.
Keywords: Autonomic dysfunction; COVID-19; Global longitudinal strain; Ventricular-arterial coupling.
. 2022 Sep 28.
doi: 10.1007/s00380-022-02180-2. Online ahead of print.
Impaired left ventricular deformation and ventricular-arterial coupling in post-COVID-19: association with autonomic dysregulation
Evangelos Oikonomou[SUP] #[/SUP][SUP] 1 2 [/SUP], Stamatios Lampsas[SUP] #[/SUP][SUP] 3 [/SUP], Panagiotis Theofilis[SUP] 4 [/SUP], Nektarios Souvaliotis[SUP] 3 [/SUP], George Aggelos Papamikroulis[SUP] 3 [/SUP], Ourania Katsarou[SUP] 3 [/SUP], Konstantinos Kalogeras[SUP] 3 4 [/SUP], Panteleimon Pantelidis[SUP] 3 [/SUP], Theodore G Papaioannou[SUP] 3 [/SUP], Aikaterini Tsatsaragkou[SUP] 3 [/SUP], Georgios Marinos[SUP] 4 [/SUP], Gerasimos Siasos[SUP] 3 5 [/SUP], Dimitris Tousoulis[SUP] 4 [/SUP], Manolis Vavuranakis[SUP] 3 4 [/SUP]
Affiliations
- PMID: 36169708
- DOI: 10.1007/s00380-022-02180-2
Abstract
Coronavirus disease-19 (COVID-19) has extended implications namely the long COVID-19 syndrome. We assessed over-time changes in left ventricular (LV) function, aortic stiffness, autonomic function, and ventricular-arterial coupling (VAC) in post-COVID-19 patients. We followed 34 post-COVID-19 subjects, up to 6 months post-hospital discharge. Subjects without COVID-19 served as control. We evaluated LV global longitudinal strain (LV-GLS), arterial stiffness [carotid-femoral pulse wave velocity (cf-PWV)], and heart rate variability -standard deviation of normal RR intervals (SDNN). VAC was estimated as the ratio of cf-PWV to LV-GLS. Post-COVID-19 individuals (1-month post-hospital discharge) presented with impaired LV-GLS [-18.4%(3.1) vs. -22.0%(2.7), P < 0.001], cf-PWV [12.1 m/s (3.2) vs. 9.6 m/s (1.9), P < 0.001], SDNN [111.3 ms (22.6) vs. 147.2 ms (14.0), P < 0.001], and VAC [-0.68 (0.22) vs. -0.44 (0.10), P < 0.001] compared to control. LV-GLS, SDNN, and VAC improved at the 6-month follow-up however they did not reach control levels. In post-COVID-19 subjects, SDNN and VAC were correlated at the 1-month (R = 0.499, P = 0.003) and 6-month (R = 0.372, P = 0.04) follow-up. Long COVID-19 syndrome was associated with impaired LV-GLS, SDNN, and VAC. Post-COVID-19 subjects presented with autonomic dysregulation associated with aortic stiffness, ventricular-arterial impairment, and LV dysfunction, even 6-months post-hospital discharge. These abnormalities may be related to the presence of long COVID-19 syndrome.
Keywords: Autonomic dysfunction; COVID-19; Global longitudinal strain; Ventricular-arterial coupling.