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Heart Lung . The incidence of pleural effusion in COVID-19 pneumonia: State-of-the-art review

tetano

Editor, Senior Moderator
Heart Lung


. 2021 Feb 27;50(4):481-490.
doi: 10.1016/j.hrtlng.2021.02.015. Online ahead of print.
The incidence of pleural effusion in COVID-19 pneumonia: State-of-the-art review


Woon H Chong[SUP] 1 [/SUP], Biplab K Saha[SUP] 2 [/SUP], Edward Conuel[SUP] 3 [/SUP], Amit Chopra[SUP] 3 [/SUP]



Affiliations

Abstract

Background: COVID-19-related pleural effusions are frequently described during the ongoing pandemic.
Objectives: We described the incidence, characteristics, and outcomes of COVID-19-related pleural effusions based on the current evidence available in the literature.
Methods: We searched MEDLINE, Pubmed, and Google Scholar databases using keywords of "coronavirus disease 2019 (COVID-19)," "severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)," "pleural effusion," "pleural fluid," and "pleura" from January 1st, 2020 to January 31st, 2021.
Results: The incidence of pleural effusions was low at 7.3% among the 47 observational studies. Pleural effusions were commonly observed in critically ill patients and had Multisystem Inflammatory Syndrome (MIS). COVID-19-related pleural effusions were identified 5-7 days and 11 days, after hospital admission and onset of COVD-19 symptoms. The characteristic findings of pleural fluid were exudative, lymphocytic or neutrophilic-predominant pleural fluid with markedly elevated lactate dehydrogenase (LDH) levels and pleural fluid to serum LDH ratio.
Conclusion: A well-designed study is required to assess the significance of COVID-19-related pleural effusions during this current pandemic.

Keywords: COVID-19; Coronavirus disease 2019; Pleura; Pleural effusion; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2.
 
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