tetano
Editor, Senior Moderator
Health Sci Rep
. 2023 Jan 27;6(2):e1080.
doi: 10.1002/hsr2.1080. eCollection 2023 Feb.
Gut microbiota and COVID-19: A systematic review
SeyedAhmad SeyedAlinaghi[SUP] 1 [/SUP], Arian Afzalian[SUP] 2 [/SUP], Zahra Pashaei[SUP] 1 [/SUP], Sanaz Varshochi[SUP] 2 [/SUP], Amirali Karimi[SUP] 2 [/SUP], Hengameh Mojdeganlou[SUP] 3 [/SUP], Paniz Mojdeganlou[SUP] 4 [/SUP], Armin Razi[SUP] 2 [/SUP], Farzaneh Ghanadinezhad[SUP] 5 [/SUP], Alireza Shojaei[SUP] 1 [/SUP], Ava Amiri[SUP] 1 [/SUP], Mohsen Dashti[SUP] 6 [/SUP], Afsaneh Ghasemzadeh[SUP] 6 [/SUP], Omid Dadras[SUP] 1 7 [/SUP], Esmaeil Mehraeen[SUP] 8 [/SUP], Amir Masoud Afsahi[SUP] 9 [/SUP]
Affiliations
Abstract
Background and aims: Alteration in humans' gut microbiota was reported in patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The gut and upper respiratory tract (URT) microbiota harbor a dynamic and complex population of microorganisms and have strong interaction with host immune system homeostasis. However, our knowledge about microbiota and its association with SARS-CoV-2 is still limited. We aimed to systematically review the effects of gut microbiota on the SARS-CoV-2 infection and its severity and the impact that SARS-CoV-2 could have on the gut microbiota.
Methods: We searched the keywords in the online databases of Web of Science, Scopus, PubMed, and Cochrane on December 31, 2021. After duplicate removal, we performed the screening process in two stages; title/abstract and then full-text screening. The data of the eligible studies were extracted into a pre-designed word table. This study adhered to the PRISMA checklist and Newcastle-Ottawa Scale Bias Assessment tool.
Results: Sixty-three publications were included in this review. Our study shows that among COVID-19 patients, particularly moderate to severe cases, the gut and lung microbiota was different compared to healthy individuals. In addition, the severity, and viral load of COVID-19 disease would probably also be influenced by the gut, and lung microbiota's composition.
Conclusion: Our study concludes that there was a significant difference in the composition of the URT, and gut microbiota in COVID-19 patients compared to the general healthy individuals, with an increase in opportunistic pathogens. Further, research is needed to investigate the probable bidirectional association of COVID-19 and human microbiome.
Keywords: COVID‐19; SARS‐CoV‐2; gut microbiota; microbiome; microbiota; probiotics.
. 2023 Jan 27;6(2):e1080.
doi: 10.1002/hsr2.1080. eCollection 2023 Feb.
Gut microbiota and COVID-19: A systematic review
SeyedAhmad SeyedAlinaghi[SUP] 1 [/SUP], Arian Afzalian[SUP] 2 [/SUP], Zahra Pashaei[SUP] 1 [/SUP], Sanaz Varshochi[SUP] 2 [/SUP], Amirali Karimi[SUP] 2 [/SUP], Hengameh Mojdeganlou[SUP] 3 [/SUP], Paniz Mojdeganlou[SUP] 4 [/SUP], Armin Razi[SUP] 2 [/SUP], Farzaneh Ghanadinezhad[SUP] 5 [/SUP], Alireza Shojaei[SUP] 1 [/SUP], Ava Amiri[SUP] 1 [/SUP], Mohsen Dashti[SUP] 6 [/SUP], Afsaneh Ghasemzadeh[SUP] 6 [/SUP], Omid Dadras[SUP] 1 7 [/SUP], Esmaeil Mehraeen[SUP] 8 [/SUP], Amir Masoud Afsahi[SUP] 9 [/SUP]
Affiliations
- PMID: 36721396
- PMCID: PMC9881458
- DOI: 10.1002/hsr2.1080
Abstract
Background and aims: Alteration in humans' gut microbiota was reported in patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The gut and upper respiratory tract (URT) microbiota harbor a dynamic and complex population of microorganisms and have strong interaction with host immune system homeostasis. However, our knowledge about microbiota and its association with SARS-CoV-2 is still limited. We aimed to systematically review the effects of gut microbiota on the SARS-CoV-2 infection and its severity and the impact that SARS-CoV-2 could have on the gut microbiota.
Methods: We searched the keywords in the online databases of Web of Science, Scopus, PubMed, and Cochrane on December 31, 2021. After duplicate removal, we performed the screening process in two stages; title/abstract and then full-text screening. The data of the eligible studies were extracted into a pre-designed word table. This study adhered to the PRISMA checklist and Newcastle-Ottawa Scale Bias Assessment tool.
Results: Sixty-three publications were included in this review. Our study shows that among COVID-19 patients, particularly moderate to severe cases, the gut and lung microbiota was different compared to healthy individuals. In addition, the severity, and viral load of COVID-19 disease would probably also be influenced by the gut, and lung microbiota's composition.
Conclusion: Our study concludes that there was a significant difference in the composition of the URT, and gut microbiota in COVID-19 patients compared to the general healthy individuals, with an increase in opportunistic pathogens. Further, research is needed to investigate the probable bidirectional association of COVID-19 and human microbiome.
Keywords: COVID‐19; SARS‐CoV‐2; gut microbiota; microbiome; microbiota; probiotics.