Hamburg strain

[gsgs]

out of 77 available viruses from Spain (NA and M only),
26+7 are probably the Hamburg strain (could be derived from LaGloria),
17 the Cancun-New York strain.

8 without mutation, could be original Mex, Cancun-Newberry or New Jersey strain or others
same for 13 with 2 special Spain mutations

 

[Mamabird]

Re: Hamburg strain

out of 77 available viruses from Spain (NA and M only),
26+7 are probably the Hamburg strain (could be derived from LaGloria),
17 the Cancun-New York strain.

8 without mutation, could be original Mex, Cancun-Newberry or New Jersey strain or others
same for 13 with 2 special Spain mutations

Yea, one is clearly related to New Jersey/01.

The S286G change in many of the NA segments is a seasonal H1N1 marker, and is showing up in the latest isolates. Recent recombination?

 

[Mamabird]

Re: Hamburg strain

out of 77 available viruses from Spain (NA and M only),
26+7 are probably the Hamburg strain

Explain to me one more time what distinguishes your "Hamburg". I thought it included unique changes within segments 1, 3 and 5 only.

 

[gsgs]

Re: Hamburg strain

no recombination
one reassortment so far

substrains: http://h5n1experts.org/forum/showpost.php?p=1133

Hamburg (3)[10,12] A1577G(1),A1741C(3),C1118T(5)

you may add T267C(5),C397A(5),G786A(6)
for the sub-sub-group NY1669,Hamburg4,Kansas03 (+Spain ?)

 

[Mamabird]

Re: Hamburg strain

no recombination
one reassortment so far

OK, so what reassorted with what? Did the Swine Flu H1N1 reassort with Seasonal H1N1, or did you have something else in mind?

 

[gsgs]

Re: Hamburg strain

reassortment in an Israel-person in April,
the two Cancun-strains, Cancun-St.Francis + Cancun-Newberry
reassorted, I reported about it here earlier...
(link)

http://www.flutrackers.com/forum/showthread.php?p=263104

 

[Mamabird]

Re: Hamburg strain

reassortment in an Israel-person in April,
the two Cancun-strains, Cancun-St.Francis + Cancun-Newberry
reassorted, I reported about it here earlier...
(link)

http://www.flutrackers.com/forum/showthread.php?p=263104

OK, I give. You have me completely stumped. What in the world is a "St. Francis" and "Newberry"? Is this some type of new naming convention?

 

[gsgs]

Re: Hamburg strain

two different Cancun strains,
one was first introduced at St.Francis school, New York
the other at Newberry Academy, South Carolina

both end of April from Cancun-travelers,
quite different strains

In the link above I called it "airplane-strain"
(not knowing about Newberry at that time...)

Although, strictly viewed it's still airplane, since I included
Narita,Beijing,Paris,Arizona/01 here, which only share 2 resp.1 of the Newberry mutations
(the major one: G546A(1))

 

[Mamabird]

Re: Hamburg strain

two different Cancun strains,
one was first introduced at St.Francis school, New York
the other at Newberry Academy, South Carolina

both end of April from Cancun-travelers,
quite different strains

In the link above I called it "airplane-strain"
(not knowing about Newberry at that time...)

Although, strictly viewed it's still airplane, since I included
Narita,Beijing,Paris,Arizona/01 here, which only share 2 resp.1 of the Newberry mutations
(the major one: G546A(1))

Alright, and many thanks! I think I'm following your convention. So, St. Francis would be New York/06 like, and Newberry would be SC/09 like?

And if that is the case then the Israel/276 reassortment ocurred in a person that was dually infected with NY and SC like viruses at exactly the same time?

Am I close? Or is there something else?

SC/09 is derived from Mexico/4115. What Mexican strain is NY/06 derived from?

 

[gsgs]

Re: Hamburg strain

yes to all
all ****** are derived from 4115-3mutations

 

[Mamabird]

Re: Hamburg strain

yes to all
all ****** are derived from 4115-3mutations

Got it.

So, from where did Israel/276 get the K526R change in PB2? I don't see that in either NY/06 (St. Francis) or SC/09 (Newberry). What am I missing? This is not a triple reassortant is it?

 

[gsgs]

Re: Hamburg strain

coincidence ?
developed independently ?
rare variant, evolved early ?

 

[HenryN]

Re: Hamburg strain

coincidence ?
developed independently ?
rare variant, evolved early ?

Martians?

 

[gsgs]

Re: Hamburg strain

out of 77 available viruses from Spain (NA and M only),
26+7 are probably the Hamburg strain (could be derived from LaGloria),
17 the Cancun-New York strain.

8 without mutation, could be original Mex, Cancun-Newberry or New Jersey strain or others
same for 13 with 2 special Spain mutations

update 22.July:
91 (77) available segments 6+7
27+7 (26+7) Hamburg
21 (17) Cancun1
11 (8) without mutations
15 (15) Spanish

 

[gsgs]

Re: Hamburg strain

> update 22.July:
> 91 (77) available segments 6+7
> 27+7 (26+7) Hamburg
> 21 (17) Cancun1
> 11 (8) without mutations
> 15 (15) Spanish


update 15.August:
140 (partial) viruses from Spain

40 Hamburg (G786A(6)) [+48%]
+7 (C1118T(5))
36 Cancun (G600A(7)) [+71%]
23 Catalonia (T990C(6),A856G(6)) [+53%]
11 Airplane (C145A(4))
3 pre-Cancun (C1408T(4),A600G(7))
20 Rest

 

[gsgs]

Re: Hamburg strain

update 2.Oct.

47.8% 108 Cancun1
19.0% 43 Hamburg
03.1% 7 pre-Cancun

33 Catalonia
9 Catalonia2
12 Baleares etc.
14 other original Mexico


---------------------
Hamburg: 26/77,27/81,40/140,43/226
Cancun: 17/77,21/81,36/140,108/226

new viruses published per period:

Hamburg:26/77,1/5,13/59,03/86
Cancun :17/77,4/5,15/59,72/86
others :34/77,0/5,31/59,11/86

-------------------------------
02.November

52.8% 133 Cancun
16.3% 41 Hamburg
31.0% 78 other non-cancun