tetano
Editor, Senior Moderator
Vet Rec Open. 2016 Jun 27;3(1):e000171. doi: 10.1136/vetreco-2016-000171. eCollection 2016.
[h=1]H9N2 low pathogenic avian influenza in Pakistan (2012-2015).[/h] Lee DH[SUP]1[/SUP], Swayne DE[SUP]1[/SUP], Sharma P[SUP]1[/SUP], Rehmani SF[SUP]2[/SUP], Wajid A[SUP]3[/SUP], Suarez DL[SUP]1[/SUP], Afonso C[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Significant economic losses from deaths and decreased egg production have resulted from H9N2 low pathogenic avian influenza virus (LPAIV) infections in poultry across North Africa, the Middle East and Asia. The H9N2 LPAIVs have been endemic in Pakistani poultry since 1996, but no new viruses have been reported since 2010. Because novel genotypes of Pakistani H9N2 contain mammalian host-specific markers, recent surveillance is essential to better understand any continuing public health risk. Here the authors report on four new H9N2 LPAIVs, three from 2015 and one from 2012. All of the viruses tested in this study belonged to Middle East B genetic group of G1 lineage and had PAKSSR/G motif at the haemagglutinin cleavage site. The mammalian host-specific markers at position 226 in the haemagglutinin receptor-binding site and internal genes suggest that Pakistan H9N2 viruses are still potentially infectious for mammals. Continued active surveillance in poultry and mammals is needed to monitor the spread and understand the potential for zoonotic infection by these H9N2 LPAIVs.
[h=4]KEYWORDS:[/h] H9N2; Pakistan; avian influenza
PMID: 27403327 PMCID: PMC4932324 DOI: 10.1136/vetreco-2016-000171
[PubMed] Free PMC Article
[h=1]H9N2 low pathogenic avian influenza in Pakistan (2012-2015).[/h] Lee DH[SUP]1[/SUP], Swayne DE[SUP]1[/SUP], Sharma P[SUP]1[/SUP], Rehmani SF[SUP]2[/SUP], Wajid A[SUP]3[/SUP], Suarez DL[SUP]1[/SUP], Afonso C[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Significant economic losses from deaths and decreased egg production have resulted from H9N2 low pathogenic avian influenza virus (LPAIV) infections in poultry across North Africa, the Middle East and Asia. The H9N2 LPAIVs have been endemic in Pakistani poultry since 1996, but no new viruses have been reported since 2010. Because novel genotypes of Pakistani H9N2 contain mammalian host-specific markers, recent surveillance is essential to better understand any continuing public health risk. Here the authors report on four new H9N2 LPAIVs, three from 2015 and one from 2012. All of the viruses tested in this study belonged to Middle East B genetic group of G1 lineage and had PAKSSR/G motif at the haemagglutinin cleavage site. The mammalian host-specific markers at position 226 in the haemagglutinin receptor-binding site and internal genes suggest that Pakistan H9N2 viruses are still potentially infectious for mammals. Continued active surveillance in poultry and mammals is needed to monitor the spread and understand the potential for zoonotic infection by these H9N2 LPAIVs.
[h=4]KEYWORDS:[/h] H9N2; Pakistan; avian influenza
PMID: 27403327 PMCID: PMC4932324 DOI: 10.1136/vetreco-2016-000171
[PubMed] Free PMC Article