H7N9 resistance to antivirals

[JetStuuby]

http://crofsblogs.typepad.com/h5n1/...tml?utm_source=twitterfeed&utm_medium=twitter

 

[Giuseppe]

Re: H7N9 resistance to antivirals

From WHO paper:

Abridged version: http://www.flutrackers.com/forum/showpost.php?p=492297&postcount=1

(...)

Sensitivity to neuraminidase inhibitors relevant to clinical management of human infection from these viruses and other antiviral drugs

The NA gene of one of the four genetically characterized viruses encodes a R292K substitution which has been associated with oseltamivir and zanamivir resistance in NAs of other subtypes.

However, this is not a universal marker for resistance to neuraminidase inhibitors in influenza A viruses (see PMID 21253602, table 1).

Phenotypic assessment of the sensitivity of these three influenza A(H7N9) viruses has shown them to be sensitive to oseltamivir and zanamivir.

The M genes of the viruses encode S31N substitution. An asparagine at residue 31 is consistent with resistance to amantadine and rimantadine. This finding has yet to be confirmed by phenotypic assay.

(...)


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