tetano
Editor, Senior Moderator
Virus Res. 2014 Mar 19. pii: S0168-1702(14)00119-1. doi: 10.1016/j.virusres.2014.03.012. [Epub ahead of print]
H5N1 infection causes rapid mortality and high cytokine levels in chickens compared to ducks.
Burggraaf S1, Karpala AJ2, Bingham J3, Lowther S3, Selleck P3, Kimpton W4, Bean AG3.
Author information
Abstract
Infection with H5N1 influenza virus is often fatal to poultry with death occurring in hours rather than days. However, whilst chickens may be acutely susceptible, ducks appear to be asymptomatic to H5N1. The mechanisms of disease pathogenesis are not well understood and the variation between different species requires investigation to help explain these species differences. Here we investigated the expression of several key proinflammatory cytokines of chickens and ducks following infection with 2 highly-pathogenic H5N1 (A/Muscovy duck/Vietnam/453/2004 (Vt453) and A/Duck/Indramayu/BBVW/109/2006 (Ind109)) and a low-pathogenic H5N3 influenza virus (A/Duck/Victoria/1462/2008 (Vc1462)). H5N1 viruses caused fatal infections in chickens as well as high viral loads and increased production of proinflammatory molecules when compared to ducks. Cytokines, including Interleukin 6 (IL6) and the acute phase protein Serum Amyloid A (SAA), were rapidly induced at 24hours post infection with H5N1. In contrast, low induction of these cytokines appeared in ducks and only at later times during the infection period. These observations support that hypercytokinemia may contribute to pathogenesis in chickens, whilst the lower cytokine response in ducks may be a factor in their apparent resistance to disease and decreased mortality.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Chicken, Cytokine storm, Duck, H5N1 avian influenza, IL6
PMID:
24657784
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24657784
H5N1 infection causes rapid mortality and high cytokine levels in chickens compared to ducks.
Burggraaf S1, Karpala AJ2, Bingham J3, Lowther S3, Selleck P3, Kimpton W4, Bean AG3.
Author information
Abstract
Infection with H5N1 influenza virus is often fatal to poultry with death occurring in hours rather than days. However, whilst chickens may be acutely susceptible, ducks appear to be asymptomatic to H5N1. The mechanisms of disease pathogenesis are not well understood and the variation between different species requires investigation to help explain these species differences. Here we investigated the expression of several key proinflammatory cytokines of chickens and ducks following infection with 2 highly-pathogenic H5N1 (A/Muscovy duck/Vietnam/453/2004 (Vt453) and A/Duck/Indramayu/BBVW/109/2006 (Ind109)) and a low-pathogenic H5N3 influenza virus (A/Duck/Victoria/1462/2008 (Vc1462)). H5N1 viruses caused fatal infections in chickens as well as high viral loads and increased production of proinflammatory molecules when compared to ducks. Cytokines, including Interleukin 6 (IL6) and the acute phase protein Serum Amyloid A (SAA), were rapidly induced at 24hours post infection with H5N1. In contrast, low induction of these cytokines appeared in ducks and only at later times during the infection period. These observations support that hypercytokinemia may contribute to pathogenesis in chickens, whilst the lower cytokine response in ducks may be a factor in their apparent resistance to disease and decreased mortality.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Chicken, Cytokine storm, Duck, H5N1 avian influenza, IL6
PMID:
24657784
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24657784